Efficacy of Prophylactic Intravenous Tranexamic Acid in Preventing Postpartum Haemorrhage in Parturients with Risk Factors: A Randomized Control Trial

Abstract

This study aims to compare the effectiveness of prophylactic intravenous Tranexamic acid (TXA) dosages of 0.5g and 1.0g in the prevention of postpartum haemorrhage (PPH) among parturient with risk factors. The research followed a randomized, double-blind, controlled experimental design, spanning nine months. Simple random sampling was used to select 154 participants to each arm. The research objectives encompassed comparing labour outcomes of the two groups and measuring blood loss via pre and post-delivery packed cell volume. Statistical analysis employed Student's t-test. Result revealed a slight non-significant difference in PCV change between 0.5g and 1.0g TXA group. The study also found that the risk of developing primary PPH when using 0.5g TXA was approximately twice the risk when using 1.0g TXA. These findings suggest that the prophylactic use of 1.0g TXA may be more effective in preventing PPH compared to 0.5g TXA. Further research is warranted to validate these results and refine recommendations for clinical practice.