Efficacy of Prussian Blue on 137Cs Decorporation Therapy

Abstract

Prussian blue (PB) is an efficient drug for enhancing cesium elimination from the body. Literature data on the efficacy of PB treatment in dosages that vary from 1-10 g d was reviewed. Cesium biokinetics was simulated using a detailed systemic biokinetic model. The same model was used to simulate the maximum action of PB by interrupting the enterohepatic circulation. Model results reproduced reasonably well the literature data on the efficacy of PB administered to humans after incidental cesium intakes, as well as results from animal experiments. Maximum efficiency of the reduction of the long-term half-time is obtained with the administration of 3 g d PB to the adult. Maximum efficiency of reducing the Cs body burdens is obtained when PB is administered on the first day after the intake, due to the increase of the short-term elimination of cesium. The model predicts that reduction of the long-term half-life is not affected by the time after intake that PB is administered, as long as it is given within the interval from 1 h to 1 y after the intake.

The Impact of Time on Decorporation Efficacy After a “Dirty Bomb” Attack Studied by Simulation

“…These procedures are time consuming and may take days or even weeks before results are available. As the efficacy of decorporation treatment depends on the time the treatment is started [7,8], it has been advocated to begin therapy as soon as possible, even if the committed effective dose is still unknown, also in consideration of the mild side-effects of therapy in the short run [9]. According to the guidelines of the French authority for nuclear safety [10] decorporation treatment should even be started on suspicion "à priori" within 2 h after incorporation ("urgent approach").…”

Benefit-Cost Analysis of Radiocesium Decorporation by a Prussian Blue Treatment and Stockpiling

“…Prussian Blue (PB) is a blue pigment that is not absorbed out of the gut, and given orally it can bind cesium-137 in the lumen of the intestine, preventing its reabsorption and thus enhancing its elimination through the feces [7]. Pharmacokinetic considerations indicate that a PB therapy is particularly effective if initiated early after the incorporation [8,9]. Thus, the initiation of a treatment as soon as possible seems prudent, particularly as the adverse effects of the treatment are reported as only slight [10].…”

“…Possible discounts or rebates granted by the manufacturer in a procurement process were not considered. Assuming a usual therapeutic dosage of 3 × 1 g PB per day [9], the purchase costs of treatment amount to 15.53 €/day. The daily costs were used to establish a linear cost function with an intercept value of 0.…”

A fiber optic sensor with a metal organic framework as a sensing material for trace levels of water in industrial gases

“…A well-known MOF is Prussian blue, which contains Fe(II), Fe(III), and CN -and has a porous three-dimensional structure which is effective to adsorption of gas molecules or ions. Recently, Prussian blue has been studied for the selective adsorption of radioactive Cs + from contaminated water [2] and the human body [3]. MOFs typically have high gas adsorption efficiencies because of their varied pore sizes [4].…”