2010
DOI: 10.1016/j.vetpar.2010.02.041
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Efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of Parascaris equorum in horses

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Cited by 26 publications
(23 citation statements)
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“…Studies carried out in recent years have indicated that these compounds may also cause oxidative stress in a host (Pinlaor et al 2008, Dewa et al 2009). The majority of publications on pyrantel mainly focus on the efficacy of its therapeutic activity (Slocombe et al 2007, Reinemeyer et al 2010, and the data on its effect on the antioxidant status include only previous publications of authors Zasadowski 2006, Barski andSpodniewska 2012). In the present study, the exposure of rats to pyrantel embonate at a dose of 1/5 LD 50 for three consecutive days caused only a slight decrease in GSH level and an increase in the activity of GPx and GR in comparison with the control group.…”
Section: Discussionmentioning
confidence: 47%
“…Studies carried out in recent years have indicated that these compounds may also cause oxidative stress in a host (Pinlaor et al 2008, Dewa et al 2009). The majority of publications on pyrantel mainly focus on the efficacy of its therapeutic activity (Slocombe et al 2007, Reinemeyer et al 2010, and the data on its effect on the antioxidant status include only previous publications of authors Zasadowski 2006, Barski andSpodniewska 2012). In the present study, the exposure of rats to pyrantel embonate at a dose of 1/5 LD 50 for three consecutive days caused only a slight decrease in GSH level and an increase in the activity of GPx and GR in comparison with the control group.…”
Section: Discussionmentioning
confidence: 47%
“…The efficacy of pyrantel products is often described in the context of their use against ivermectin-resistant ascarid populations. Such studies were conducted in the USA and Europe and all of them confirmed a good effect of tetrahydropyrimidines on resistant ascarid populations (Slocombe et al 2007;von Samson-Himmelstjerna et al 2007;Reinemeyer 2009;Reinemeyer et al 2010).…”
Section: Discussionmentioning
confidence: 79%
“…This solution is not realistic, though, because exposure of foals occurs gradually, the foals are simultaneously infected by various developmental stages of the parasites and younger, less susceptible developmental stages can survive the therapy (Reinemeyer 2012). Some authors recommend starting anthelmintic therapy around 60-70 days after birth on farms where ascarid infection in foals poses a problem in order to reduce the pasture contamination (Reinemeyer et al 2010).…”
Section: Discussionmentioning
confidence: 99%
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“…Resistance clearly involves the entire macrocyclic lactone class because sequential dosing of individual foals with ivermectin and moxidectin failed to reduce egg counts after either treatment (Reinemeyer et al, 2010).…”
Section: Introductionmentioning
confidence: 99%