Efficacy of repeated 5-fluorouracil needling for failing and failed filtering surgeries based on simple gonioscopic examination

Rashad, Mohammad A

doi:10.2147/opth.s34848

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…It is frequently used in ophthalmology as an adjuvant in the treatment of various ocular diseases such as pterygium [2] and glaucoma [3] to improve the success of clinical therapy. In glaucoma surgery, 5-FU was introduced as an adjunct agent administered by repeated subconjunctival injections after trabeculectomy to inhibit the proliferation of fibroblasts [4] [5].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of 5-Fluorouracil-Induced Apoptosis on Cultured Corneal Endothelial Cells

Hong¹,

Wu²,

Lai³

et al. 2014

OJApo

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Section: Introductionmentioning

confidence: 99%

Mechanism of 5-Fluorouracil-Induced Apoptosis on Cultured Corneal Endothelial Cells

Hong¹,

Wu²,

Lai³

et al. 2014

OJApo

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“…Some previous studies present similar successful results (8,9). Tatham et al (8) reported that 5-FU is an effective technique for trabeculectomy bleb remodeling and can result in a sustained reduction in IOP.…”

Section: Discussionmentioning

confidence: 68%

“…Tatham et al (8) reported that 5-FU is an effective technique for trabeculectomy bleb remodeling and can result in a sustained reduction in IOP. Rashad (9) reported that a significant reduction of mean IOP from 36.91 mmHg to 14.73 mmHg is achieved at the final follow-up and the overall success rate was 92%. He added that repeated needling with adjunctive 5-FU proved a highly effective in managing bleb failure (9).…”

Section: Discussionmentioning

confidence: 99%

Bleb yetersizliğinin tedavisinde subkonjonktival 5-fluorourasil kullanımının sonuçları: Olgu serisi

Yılmaz¹,

Aygıt²,

Erdur³

et al. 2015

Ege Tıp Dergisi

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Aim: To evaluate the efficacy of 5-Fluorouracil (5-FU) injections in eyes with bleb failure and uncontrolled intraocular pressure (IOP) after trabeculectomy. Materials and Methods:Fifteen eyes of 15 patients (6 female, 9 male) were included in this retrospective study. All patients had trabeculectomy surgery for the treatment of primary open angle glaucoma. During the first year followups, cases with IOP higher than 21 mmHg and ineffective blebs were considered as bleb failure. We used 5-FU subconjunctival injections, in the same concentration (5 mg) but in different numbers, to treat the bleb failure and lower the IOP. The efficacy of the treatment was evaluated. Results:The mean age was 59.3±12.4 years (range 43-74 years). The mean 5-FU injection count was 5.27±1.58 injections (range 2-7). The mean IOP was reduced to 17.07±7.10 mmHg after treatment. There was a statistically significant difference in IOP levels before and after the injections (p<0.05).Conclusion: 5-FU injection treatment is safe and effective for the treatment of bleb failure after trabeculectomy.Keywords: Trabeculectomy, bleb failure, 5-FU, 5-fluorouracil. Öz Amaç: Trabekülektomi sonrasında bleb yetersizliği ve göz içi basınç (GİB) yüksekliği olan gözlerde 5-Fluorouracil (5-FU) enjeksiyonlarının etkinliğini değerlendirmek. Gereç ve Yöntem: Retrospektif çalışmaya 15 hastanın 15 gözü (6 kadın, 9 erkek) dahil edildi. Tüm hastalar daha önce açık açılı glokom nedeniyle trabekülektomi olmuştu. Birinci yıl takipleri sırasında, GİB'ının 21 mmHg'den yüksek olması ve inefektif bleb varlığı bleb yetersizliği olarak değerlendirildi. Bleb yetersizliğini tedavi etmek ve GİB'ını düşürmek için bu hastalara aynı dozda (5 mg) fakat farklı sayılarda subkonjonktival 5-FU enjeksiyonları uygulandı. Tedavi etkinliği değerlendirildi.Bulgular: idi. Ortalama GİB tedaviyle 17.07±7.10 mmHg'ya düştü. Enjeksiyonlar öncesi ve sonrası dönem arasında GİB seviyelerinde istatistiksel olarak anlamlı düşüş tespit edildi (p<0.05). Sonuç: 5-FU enjeksiyon tedavisi, trabekülektomi sonrası bleb yetmezliği olan vakalarda güvenli ve efektiftir.Anahtar Sözcükler: Trabekülektomi, bleb yetersizliği,

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“…IOP > 30 mmHg before the procedure, high IOP after the procedure, lack of use antimetabolite in previous filtration surgery, type of glaucoma are the risk factors that affect the efficiency of the BNR procedure [22]. Generally, repeated BNR with adjunctive 5-FU provide revive of filtration in dysfunctional bleb and prevent other surgery [23]. Indeed, additional surgery may be needed in some cases.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of bleb needling revision with 5-fluorouracil in encapsulated bleb after unsuccessful trabeculectomy

Okka

Mirza

Oltulu

et al. 2019

The European Research Journal

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Objectives: To investigate the efficacy of the bleb needling revision (BNR) procedure with the adjunctive use of 5-Fluorouracil (5-FU) in encapsulated bleb after unsuccessful trabeculectomy. Methods: We reviewed 16 eyes of 15 subjects who underwent BNR procedure due to encapsulated bleb after unsuccessful trabeculectomy. Demographic data, type of glaucoma, intraocular pressure (IOP) values of pre-BNR, IOP values of post-BNR at first day, first week and first month, follow up time and complications were recorded from patients' files, retrospectively. Results: The mean follow up time was 53.1 ± 26.4 weeks. The average time between previous unsuccessful trabeculectomy and BNR was 11.12 ± 8.79 weeks. The mean IOP of pre-BNR was 26.0±4.4 mmHg and significantly decreased to 12.4 ± 5.0 mmHg post-BNR at the first day (p < 0.001). The mean IOP values of post-BNR at the first week was 13.3 ± 4.9 mmHg and at the first month was 14.8 ± 4.8 mmHg. According to the mean IOP of pre-BNR, the mean IOP values of post-BNR at the first week and at the first month were significantly lower (p < 0.001 and p < 0.001, respectively). Seven (44%) eyes were achieved success and eight (50%) eyes were achieved qualified success. One (6%) eye was classified as the failure. Conclusion: The bleb needling revision procedure with the adjunctive use of 5-FU in encapsulated bleb after unsuccessful trabeculectomy is a simple, useful and repeatable method to restore the dysfunctional bleb.

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Efficacy of repeated 5-fluorouracil needling for failing and failed filtering surgeries based on simple gonioscopic examination

Cited by 7 publications

References 23 publications

Mechanism of 5-Fluorouracil-Induced Apoptosis on Cultured Corneal Endothelial Cells

Mechanism of 5-Fluorouracil-Induced Apoptosis on Cultured Corneal Endothelial Cells

Bleb yetersizliğinin tedavisinde subkonjonktival 5-fluorourasil kullanımının sonuçları: Olgu serisi

The efficacy of bleb needling revision with 5-fluorouracil in encapsulated bleb after unsuccessful trabeculectomy

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