Efficacy of Restricting Dietary Protein Intake Combined with Buyang Huanwu Decoction in Treating Diabetic Nephropathy and Its Effect on Patients’ Inflammatory Factor Levels

Abstract

Objective. To study the efficacy of restricting dietary protein intake combined with Buyang Huanwu decoction in treating diabetic nephropathy (DN) and its effect on patients’ inflammatory factor levels. Methods. The medical data of 150 DN patients treated in Wuhan No.1 Hospital (June 2018—May 2021) were retrospectively analyzed. All patients received regular therapy, those who received the intervention of restricting dietary protein intake were included in the control group (n = 75), and on this basis, those treated with Buyang Huanwu decoction were included in the experimental group (n = 75), so as to scientifically evaluate their efficacy and inflammatory factor levels after treatment. Results. The patients’ general information was not statistically different between the two groups ( P > 0.05 ); after treatment, the experimental group gained remarkably higher marked effective rate and total effective rate of treatment than the control group ( P < 0.05 ); the inflammatory factor levels of all patients were obviously better than before ( P < 0.05 ), and the levels of TNF-α, IL-2, IL-8, IL-4, and IL-10 were obviously lower in the experimental group than in the control group ( P < 0.05 ); the levels of fasting blood glucose, 2 h postprandial blood glucose, and glycosylated hemoglobin of all patients were remarkably lower than before ( P < 0.05 ), but with no significant between-group difference ( P > 0.05 ); the renal function indexes of all patients were better than before, and between the two groups, the levels of 24 h microalbuminuria, 24 h urine protein excretion, and serum creatinine were obviously lower and the glomerular filtration rate was significantly higher in the experimental group ( P all <0.05), and the patients’ traditional Chinese medicine (TCM) symptom scores were remarkably lower in the experimental group ( P < 0.05 ). Conclusion. Jointly applying Buyang Huanwu decoction on the basis of restricting dietary protein intake can effectively promote the clinical efficacy of DN, which is conducive to adjusting the inflammatory factor levels, promoting the patients’ renal function, and alleviating the clinical symptoms.

Component-Effect Relationship between HPLC Fingerprints and Lipid-Lowering Activity of Buyang Huanwu Decoction

“…In the clinical study, BHD was supplemented in patients on the basis of routine treatment. The results showed that the levels of fasting blood glucose, triglyceride, and inflammation in patients treated with BHD decreased significantly [ 5 , 18 ]. However, the efficacy material basis of BHD is not clear, which restricts the development and application of prescription.…”

“…Recent studies show that BHD has a positive effect on the treatment of diabetes and atherosclerosis [ 3 , 4 ]. In Chinese clinical practice, there are many cases where BHD is used in the treatment of diabetes, which greatly improves the quality of life of patients [ 5 , 6 ]. Diabetic patients often show disorders of glucose and lipid metabolism.…”

Advances in Traditional Chinese Medicine research in diabetic kidney disease treatment

“…Additionally, a single-center RCT study including 150 patients proved that on the basis of restricting dietary protein intake, combined with oral Buyang Huanwu Decoction 1 dose per day for 3 months, can also significantly improve the renal function indicators of patients, help regulate the level of inflammatory factors, and effectively improve the clinical efficacy of DKD (Chen et al. 2021 ).…”