Efficacy of Right Unilateral Ultrabrief Pulse Width ECT

Magid, Michelle; Truong, Liz; Treviño, Kenneth; Husain, Mustafa M.

doi:10.1097/yct.0000000000000080

Cited by 7 publications

(10 citation statements)

References 12 publications

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“…Three retrospective studies used assessment data gathered prospectively (Agarkar et al, 2012; Magid et al, 2013; Narayanaswamy et al, 2014). …”

Section: Resultsmentioning

confidence: 99%

“…Eight of these studies reported final acute antidepressant outcomes (Daly et al, 2001; Stromgren, 1973; Sackeim and Prudic, 2005; Medda et al, 2009; Sienaert et al, 2009; Agarkar et al, 2012; Magid et al, 2013; Narayanaswamy et al, 2014). These outcomes mainly overlapped in BPD and MDD.…”

Section: Resultsmentioning

confidence: 99%

“…Five reports (Daly et al, 2001; Sackeim and Prudic, 2005; Medda et al, 2009; Sienaert et al, 2009; Magid et al, 2013) presented proportions of responders in BPD and MDD. These ranged from 69% to 85% in BPD and 63–94% in MDD, and they did not differ (Table 1).…”

Section: Resultsmentioning

confidence: 99%

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Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder

Agarkar

Hurt

Young

2018

Psychiatry Research

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Aims We reviewed studies that reported speed of antidepressant response to electroconvulsive therapy (ECT) in both bipolar depression (BPD) and major depressive disorder (MDD). Methods We identified English language reports allowing this comparison. Results Ten studies met our criteria. Four reported significantly faster response in BPD and in one there was trend for faster response. None reported evidence for slower response in BPD. Conclusion The findings support further study of speed of response to ECT in BPD.

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“…Three retrospective studies used assessment data gathered prospectively (Agarkar et al, 2012; Magid et al, 2013; Narayanaswamy et al, 2014). …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder

Agarkar

Hurt

Young

2018

Psychiatry Research

View full text Add to dashboard Cite

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“…Our review reported a multitude of studies, many seeking to establish whether one type of ECT is more effective, or produces less cognitive dysfunction, than another; but all simply assuming that it does work. Only two studies in the last six years have made an explicit attempt to determine whether ECT works (Magid et al, 2013;Schoeyen et al, 2015). Both were so methodologically flawed as to be unable to answer the question in a scientifically meaningful way.…”

Section: Discussionmentioning

confidence: 99%

“…It has no data beyond the end of the treatment period and no control group, placebo or otherwise. Magid et al (2013) observational studies, 10 RCTs including an ECT only group, two non-randomized trials, and two retrospective reviews. In none of these studies was ECT compared to any kind of control group and, therefore, reductions in depression cannot be attributed to ECT.…”

Section: Changes In Depression During the Treatment Periodmentioning

confidence: 99%

Is Electroconvulsive Therapy for Depression More Effective Than Placebo? A Systematic Review of Studies Since 2009

Read

Arnold

2017

Ethical Hum Psychol Psychiatry

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Is electroconvulsive therapy for depression more effective than placebo? A systematic review of studies since 2009. ABSTRACTBackground: A 2010 review of studies and previous reviews and meta-analyses found minimal evidence that ECT for depression was more effective than placebo during the treatment period and no evidence at all of efficacy beyond the end of treatment. The current review explored whether any contradictory evidence has since been generated. Method: MEDLINE and PsycINFO were searched to identify all post 2009 studies that had compared ECT and simulated ECT for depression, or had in any other way generated valid depression data for ECT recipients at two or more points in time. Results: Ninety-one studies met inclusion criteria. There were no new placebo-controlled trials. There have now been no such studies since 1985. Only four placebo-controlled studies have ever produced data beyond the end of treatment, none of which had found any advantage for ECT over placebo. Of the 91 studies only two aimed to evaluate the efficacy of ECT. Both were severely flawed. None of the other 89 produced robust evidence that ECT is effective for depression, primarily because at least 60% maintained ECT participants on medication and 89% produced no meaningful follow up data beyond the end of treatment. No studies investigated whether ECT prevents suicide. Conclusions: There is still no evidence that ECT is more effective than placebo for depression reduction or suicide prevention. Given the 1 well-documented high risk of persistent memory dysfunction, the cost-benefit analysis for ECT remains so poor that its use cannot be scientifically, or ethically, justified.

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Ketamine or ECT? What Have We Learned From the KetECT and ELEKT-D Trials?

Ekstrand,

Takamiya,

Nordenskjold

et al. 2023

International Journal of Neuropsychopharmacology

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Two recent clinical trials, KetECT and ELEKT-D, compared the effectiveness of ketamine and electroconvulsive therapy (ECT) for major depressive disorder. Notably, these trials reported marked differences in ECT’s clinical outcomes of, with remission rates of 63% for KetECT and a strikingly lower rate of 22% for ELEKT-D, while the remission rates for ketamine were 46% and 38%, respectively. Considering that the primary objective of both trials was to compare the standard treatment (ECT) with an experimental intervention (ketamine), it is crucial to highlight the pronounced disparities in ECT’s clinical outcomes. This article offers a comprehensive comparison of these trials while also exploring how patient characteristics, treatment protocols, and study designs may contribute to such pronounced outcome discrepancies. These differences highlight the heterogeneous nature of depression and underscore the need for personalized treatments. These studies also provide valuable insights into identifying the most suitable candidates for ketamine and ECT.

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Efficacy of Right Unilateral Ultrabrief Pulse Width ECT

Cited by 7 publications

References 12 publications

Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder

Speed of antidepressant response to electroconvulsive therapy in bipolar disorder vs. major depressive disorder

Is Electroconvulsive Therapy for Depression More Effective Than Placebo? A Systematic Review of Studies Since 2009

Ketamine or ECT? What Have We Learned From the KetECT and ELEKT-D Trials?

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