Efficacy of S-PRG filler varnishes on enamel caries remineralization

Moecke, Sabrina Elise; Silva, Ana Gabriele de Cassia Santos; Andrade, Adrielle Caroline Moreira; Borges, Alessandra Bühler; Torres, Carlos Rocha Gomes

doi:10.1016/j.jdent.2022.104074

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…1). In agreement, other recent in vitro study showed that a varnish containing 40% S-PRG fillers was the most effective to promote enamel caries remineralization, followed by one containing 5% NaF, which can represent an alternative for initial enamel caries remineralization [Moecke et al, 2022]. Once again, no in situ or clinical study has been done on it, highlighting the relevance of our data.…”

Section: Discussionsupporting

confidence: 91%

“…The S-PRG filler releases not only fluoride (F − ) ions but also other ions such as strontium (Sr 2+ ), sodium (Na + ), boron (BO 3 3− ), aluminum (Al 3+ ), and silica (SiO 3 2− ) at high concentrations [Amaechi et al, 2017;Spinola et al, 2020]. Therefore, it seems to be promising for dental caries control by the release of ions that interact with the tooth surface with antimicrobial action [Amaechi et al, 2017[Amaechi et al, , 2018Nomura et al, 2018;Rossoni et al, 2019;Kato et al, 2020], able to reduce demineralization [Spinola et al, 2020], and to improve remineralization [Moecke et al, 2022]. However, little information is available about the effect of S-PRG filler into an experimental toothpaste on enamel remineralization and nothing has been done in situ, which is the model closest to the in vivo condition.…”

Section: Introductionmentioning

confidence: 99%

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Effect of a Toothpaste Containing Surface Pre-Reacted Glass-Ionomer Filler on the Remineralization of Artificial Carious Enamel Lesions in situ

Vertuan¹,

Silva²,

Ferreira³

et al. 2022

Caries Res

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This study evaluated the remineralizing effect of a toothpaste containing surface pre-reacted glass-ionomer (S-PRG) filler on demineralized enamel in situ. For this, 180 bovine enamel samples were demineralized by using a microcosm biofilm model for 3 days. Thereafter, the samples were randomly signed to 15 healthy volunteers and to 3 cross-over in situ phases corresponding to the following treatments: 1) toothpaste containing 1500 ppm F as NaMFP (positive control, Colgate® Cavity Protection), 2) toothpaste containing 5% S-PRG filler (Shofu®), and 3) placebo toothpaste (negative control prepared by Shofu®). Four demineralized enamel blocks were fixed into each palatal appliance per phase. The volunteers wore the appliances for 5 days and were trained to brush their teeth 2 times for 2 minute a day, while one drop of the toothpaste’s slurry (1:3) was dripped on each sample for the same period. The surface hardness and TMR analyses were done and analyzed by ANOVA/Tukey and t test (p<0.05). S-PRG filler and Colgate® toothpastes were equally able to improve 2-2.5x enamel remineralization by the analysis of % surface hardness recovery. However, S-PRG toothpaste was the only one able to significantly improve ΔΔZ (the integrated mineral loss recovery: 1489 ± 503 %vol.μm) compared to placebo (1050 ± 467 %vol.μm), while Colgate® did not differ from placebo. No differences were seen between the groups with respect to ΔLD. S-PRG filler and Colgate® toothpastes shows similar potential to remineralize the lesion surface. However, S-PRG toothpaste is better to recovery mineral loss at the subsurface area.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effect of a Toothpaste Containing Surface Pre-Reacted Glass-Ionomer Filler on the Remineralization of Artificial Carious Enamel Lesions in situ

Vertuan¹,

Silva²,

Ferreira³

et al. 2022

Caries Res

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show abstract

“…Moecke et al [60] investigated the remineralizing effects of experimental varnishes containing S-PRG filler. They revealed that the varnish containing 40% S-PRG filler more effectively promoted the remineralization of demineralized bovine enamel compared with the varnish containing 5% sodium fluoride.…”

Section: Caries Prevention/managementmentioning

confidence: 99%

Multiple-Ion Releasing Bioactive Surface Pre-Reacted Glass-Ionomer (S-PRG) Filler: Innovative Technology for Dental Treatment and Care

Imazato

Nakatsuka

Kitagawa

et al. 2023

JFB

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Surface Pre-Reacted Glass-ionomer (S-PRG) filler, which releases strontium (Sr2+), borate (BO33−), fluoride (F−), sodium (Na+), silicate (SiO32−), and aluminum (Al3+) ions at high concentrations, is a unique glass filler that are utilized in dentistry. Because of its multiple-ion releasing characteristics, S-PRG filler exhibits several bioactivities such as tooth strengthening, acid neutralization, promotion of mineralization, inhibition of bacteria and fungi, inhibition of matrix metalloproteinases, and enhancement of cell activity. Therefore, S-PRG filler per se and S-PRG filler-containing materials have the potential to be beneficial for various dental treatments and care. Those include restorative treatment, caries prevention/management, vital pulp therapy, endodontic treatment, prevention/treatment of periodontal disease, prevention of denture stomatitis, and perforation repair/root end filling. This review summarizes bioactive functions exhibited by S-PRG filler and its possible contribution to oral health.

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“…In another study, the remineralization capacity of PRG filled with different concentrations of sodium fluoride was compared to that of 5% sodium fluoride [75]. It was found that PRG containing 40% sodium fluoride was more effective at tooth remineralization than 5% sodium fluoride filler.…”

Section: Bioactive Glassmentioning

confidence: 99%

Engineered Biomaterials Trigger Remineralization and Antimicrobial Effects for Dental Caries Restoration

Li,

Liu,

Xue

et al. 2023

Molecules

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Dental caries is the most prevalent chronic disease globally, significantly impacting individuals’ quality of life. A key reason behind the failure of implanted restorations is their biological inactivity, meaning they are unable to form crosslinks with the surrounding tooth structures, thus making patients susceptible to implant loss and recurrent tooth decay. For the treatment of caries, antibacterial medicine and remineralization are effective means of treating the recurrence of caries. Owing to the rapid progression in the biomaterials field, several biomaterials have been reported to display antimicrobial properties and aid in dentin remineralization. Bioactive materials hold considerable potential in diminishing biofilm accumulation, inhibiting the process of demineralization, enabling dentin remineralization, and combating bacteria related to caries. Bioactive materials, such as fluoride, amorphous calcium phosphate, bioactive glass, collagen, and resin-based materials, have demonstrated their effectiveness in promoting dentin remineralization and exerting antibacterial effects on dental caries. However, the concentration of fluoride needs to be strictly controlled. Although amorphous calcium phosphate can provide the necessary calcium and phosphorus ions for remineralization, it falls short in delivering the mechanical strength required for oral mastication. Resin-based materials also offer different advantages due to the complexity of their design. In this review, we delve into the application of advanced bioactive materials for enhancing dentin remineralization and antibacterial properties. We eagerly anticipate future developments in bioactive materials for the treatment of dental caries.

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Efficacy of S-PRG filler varnishes on enamel caries remineralization

Cited by 9 publications

References 33 publications

Effect of a Toothpaste Containing Surface Pre-Reacted Glass-Ionomer Filler on the Remineralization of Artificial Carious Enamel Lesions in situ

Effect of a Toothpaste Containing Surface Pre-Reacted Glass-Ionomer Filler on the Remineralization of Artificial Carious Enamel Lesions in situ

Multiple-Ion Releasing Bioactive Surface Pre-Reacted Glass-Ionomer (S-PRG) Filler: Innovative Technology for Dental Treatment and Care

Engineered Biomaterials Trigger Remineralization and Antimicrobial Effects for Dental Caries Restoration

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