Efficacy of sarolaner on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs

Oliveira, Priscila Cardim de; Almeida, Gabriela Pereira Salça de; Cardoso, Jaime Dias; Tavares, Renan Bernardes; Fernandes, Júlio Israel; Correia, Thaís Ribeiro; Verocai, Guilherme G.; Scott, Fábio Barbour

doi:10.1016/j.vetpar.2019.108966

Cited by 11 publications

(11 citation statements)

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“…In companion animals, different drug classes including macrocyclic lactones, spinosyns and neonicotinoids have been used in the clinical management and control of cutaneous myiasis [ 5 , 7 , 13 , 14 ]. Recently, the off-label use of isoxazolines such as sarolaner and afoxolaner has been proven efficacious against myiasis caused by C. hominivorax in dogs [ 7 , 14 ], lotilaner against C. bezziana [ 6 ], and fluralaner for treating D. hominis in cats [ 15 ].…”

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confidence: 99%

Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)

et al. 2021

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Background The human botfly, Dermatobia hominis, is a common cause of furuncular myiasis in dogs in Latin America. Lesions can be single or multiple, each harboring an individual larva, presented as an erythematous nodule that causes pruritus and pain. Typical treatment consists of sedation for removal of larvae by surgical incision or manual pressure. Medications to kill the larva before its extraction can reduce inflammation and discomfort and provide a less traumatic larval removal. Isoxazolines are broad-spectrum ectoparasiticides with larvicidal activity previously reported in the treatment of screwworm myiasis in companion animals. The aim of this study was to evaluate the effectiveness of sarolaner as part of the clinical management of furuncular myiasis in dogs caused by D. hominis larvae. Methods Ten short-haired mixed breed dogs naturally infested with D. hominis were enrolled. Clinical diagnosis was achieved by observation of skin nodules and visualization of larval motility through the lesion orifice. Sarolaner was administered at manufacturer recommended dose for fleas and ticks. Lesions were reexamined 24 h post-treatment and assessed for viability of larvae. Larvae were removed by digital compression and identified as D. hominis. Results Seventy-five D. hominis larvae were retrieved from ten dogs. No live larvae were observed, demonstrating 100% larvicidal efficacy of sarolaner. Skin lesions were healed 30 days post-treatment and new lesions were not observed. Conclusions Sarolaner seems to be effective as larvicidal treatment for dogs with furuncular myiasis, reducing discomfort caused by the presence of the larva in the skin and facilitating its safe removal. Graphical abstract

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Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)

et al. 2021

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“…ECO 20 and raw oil-resin (CrD-Ore—control) were selected for in vivo studies and used to treat two different groups. Animals diagnosed with myiasis, a pathological condition in which larvae of holometabolic insects infest ulcerative lesions, received daily topical administration of the products (CrD-Ore or ECO 20 ) [ 12 ]. In the sector’s routine, conventional treatments for lesions were carried out with the use of Boi Forte brand spray Mata bicheiras , associated with Tanicid (healing powder) for complete healing.…”

Section: Resultsmentioning

confidence: 99%

“…As a result, ulcerative lesions usually appear accompanied by bacterial infections (myiasis of the traumatic type, relative to open wounds), leading to death if not treated [ 2 , 10 , 11 ]. Although myiasis is a typical human disease, the problem becomes critical in cattle, sheep, horses, goats, and dogs [ 12 , 13 ]. In the cattle industry, it represents a significant economic impact due to falls in milk productivity (losses of millions of dollars), weight gain, and fertility index, problems that can lead small ruminants to toxemia and death.…”

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Design and Optimization of a Natural Medicine from Copaifera reticulata Ducke for Skin Wound Care

et al. 2022

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In this study, we developed a bioadhesive emulsion-filled gel containing a high amount of Copaifera reticulata Ducke oil-resin as a veterinary or human clinical proposal. The phytotherapeutic system had easy preparation, low cost, satisfactory healing ability, and fly repellency, making it a cost-effective clinical strategy for wound care and myiasis prevention. Mechanical, rheological, morphological, and physical stability assessments were performed. The results highlight the crosslinked nature of the gelling agent, with three-dimensional channel networks stabilizing the Copaifera reticulata Ducke oil-resin (CrD-Ore). The emulgel presented antimicrobial activity, satisfactory adhesion, hardness, cohesiveness, and viscosity profiles, ensuring the easy spreading of the formulation. Considering dermatological application, the oscillatory responses showed a viscoelastic performance that ensures emulgel retention at the action site, reducing the dosage frequencies. In Vivo evaluations were performed using a case report to treat ulcerative skin wounds aggravated by myiasis in calves and heifers, which demonstrated healing, anti-inflammatory, and repellent performance for the emulsion-filled gel. The emulgel preparation, which is low in cost, shows promise as a drug for wound therapy.

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“…This result is in agreement with those from earlier efficacy studies against fleas, where 64.0% of adult Ctenocephalides felis were eliminated 2 h after treatment [ 21 ]. Insecticidal compounds that have a rapid onset of efficacy are preferred options for treating primary myiasis in dogs as they allow quick restoration of quality of life [ 15 ]. Therefore, a high and rapid expulsion of larvae is important, as it can promote faster healing of lesions and prevent animals from having to undergo procedures such as sedation and prolonged antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of lotilaner against myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs

et al. 2023

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Background The New World screwworm fly, Cochliomyia hominivorax, is widely distributed across South America. This parasitic insect is a significant cause of primary myiasis in animals, including dogs. There is an urgent need for a rapid and efficient treatment to improve the recovery of affected animals. In the present study we evaluated the potential of lotilaner for the treatment of myiasis caused by C. hominivorax larvae in naturally infested dogs. Lotilaner belongs to the isoxazoline class of chemical compounds and is marketed as Credelio™ for use against ticks and fleas in dogs and cats. Methods Eleven dogs with naturally acquired myiasis were enrolled in this study based on the severity of lesions and the number of identified larvae. All animals received a single oral administration of lotilaner at a minimum dose of 20.5 mg/kg body weight. After treatment, the number of expelled larvae, live or dead, was determined at 2, 6 and 24 h, and the larval expulsion rate, larvicidal effect and overall efficacy were calculated. After 24 h, the remaining larvae were removed, counted and identified. The lesions were cleaned, and palliative treatment was administered when necessary, according to the animal's health status. Results All larvae were identified as C. hominivorax. The larval expulsion rate was 80.5% and 93.0% at 2 and 6 h post-treatment, respectively. Lotilaner showed an overall efficacy of 100% at 24 h post-treatment. Conclusions Lotilaner demonstrated a rapid onset of action and a high efficacy against C. hominivorax. We therefore recommend lotilaner for the effective treatment of myiasis in dogs. Graphical Abstract

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Efficacy of sarolaner on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs

Cited by 11 publications

References 11 publications

Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)

Effectiveness of sarolaner in the clinical management of furuncular myiasis in dogs naturally infested with Dermatobia hominis (Diptera: Cuterebridae)

Design and Optimization of a Natural Medicine from Copaifera reticulata Ducke for Skin Wound Care

Efficacy of lotilaner against myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in naturally infested dogs

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