Efficacy of Sclerotherapy in Varicose Veins—A Prospective, Blinded, Placebo-Controlled Study

Kahle, Birgit; Leng, Katharina

doi:10.1097/00042728-200405000-00014

Cited by 24 publications

(39 citation statements)

References 19 publications

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“…These results are comparable to those achieved with surgical or other interventional endovascular procedures. 7,[10][11][12][13][14][15][16][17][18][19] Our study consisted of a representative number of patients with uncomplicated VVs (59%) and severe venous insufficiency (41%) referred to a vascular outpatient clinic. We have demonstrated that the rate of complete and partial obliteration does not differ between these patients.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of foam sclerotherapy for the treatment of varicose veins

Nael

Rathbun

2009

Vasc Med

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Varicose veins (VVs) are associated with lifestyle-limiting symptoms and complications. Patients who fail compression therapy are candidates for more invasive treatments. This study evaluates the efficacy and safety of endovenous foam sclerotherapy (EFS) for the treatment of VVs in a US academic center. We reviewed medical records of a consecutive cohort of patients who underwent EFS over a 2-year period. The primary outcome measure was obliteration of VVs. The secondary outcome measures were symptomatic improvement, ulcer healing, recurrence, and adverse events. A total of 166 patients (217 legs) underwent EFS for pain (81%), pruritis (41%), swelling (17%), ulcerations (17%), thrombophlebitis (14%), and varix rupture (3%). Complete (65%) or near-complete (34%) obliteration was achieved in 215 (99%) legs after one injection. Additional injections achieved complete obliteration in 39 of 53 legs. Ninety-three percent (27/29) of active ulcers healed or were decreasing in size. Five ulcers and 11 VVs recurred. Common adverse events included pain and hyperpigmentation. Thrombosis, hematoma, skin necrosis, and neurologic events were rare. In conclusion, EFS appears to be a safe and effective outpatient therapy for the treatment of symptomatic and complicated VVs.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of foam sclerotherapy for the treatment of varicose veins

Nael

Rathbun

2009

Vasc Med

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“…Sclerosing agents such as polidocanol have been shown to be superior to normal saline in both obliterating incompetent varicose veins and improving venous hemodynamics at 12 weeks. 98 In Europe, sclerotherapy with polidocanol foam with duplex ultrasound guidance has become standard in the treatment of intracutaneous telangiectasis, subcutaneous varicose veins, transfascial perforating veins, and venous malformations. 99 In a randomized, controlled trial, 430 patients with varicose veins with an incompetent GSV were treated with either ultrasound guided foam sclerotherapy or surgical ligation and stripping.…”

Section: Exercise Therapymentioning

confidence: 99%

Chronic Venous Insufficiency

2014

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“…Sclerosing agents such as polidocanol have been shown to be superior to normal saline in both obliterating incompetent varicose veins and improving venous hemodynamics at 12 weeks. 69 In Europe, sclerotherapy with polidocanol foam with duplex ultrasound guidance has become standard in the treatment of intracutaneous telagectasies, subcutaneous varicose veins, transfascial perforating veins, and venous malformations. 70 This efficient method of sclerosing is not yet approved in the United States.…”

Section: Interventional Treatmentmentioning

confidence: 99%

Chronic Venous Insufficiency

2005

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C hronic venous disease is often overlooked by primary and cardiovascular care providers because of an underappreciation of the magnitude and impact of the problem. The importance of chronic venous disease is related to the number of people with the disease and the socioeconomic impact of its more severe manifestations. Unfortunately, the literature concerning the prevalence and incidence of chronic venous disease has varied greatly because of differences in the methods of evaluation, criteria for definition, and the geographic regions analyzed. The most common manifestations of chronic venous disease are dilated cutaneous veins, such as telangiectases and reticular veins, and varicose veins. The term chronic venous insufficiency (CVI) describes a condition that affects the venous system of the lower extremities with venous hypertension causing various pathologies including pain, swelling, edema, skin changes, and ulcerations. Although the term CVI is often used to exclude uncomplicated varicose veins, varicose veins have incompetent valves with increased venous pressure leading to progressive dilation and tortuosity. We will use the term CVI to represent the full spectrum of manifestations of chronic venous disease.Varicose veins have an estimated prevalence between 5% to 30% in the adult population, with a female to male predominance of 3 to 1, although a more recent study supports a higher male prevalence. 1 The Edinburgh Vein Study screened 1566 subjects with duplex ultrasound for reflux finding CVI in 9.4% of men and 6.6% of women, after age adjustment, which rose significantly with age (21.2% in men Ͼ50 years old, and 12.0% in women Ͼ50 years old). 2 The San Valentino Vascular Screening Project found among the 30 000 subjects evaluated by clinical assessment and duplex ultrasound a prevalence of 7% for varicose veins and 0.86% for "symptomatic" CVI. 3 As in previous studies, CVI was more common with increasing age, but there was no significant sex difference. The rate of varicose vein development may be estimated from the Framingham Heart Study, which found an annual incidence of 2.6% in women and 1.9% in men. 4 Risk factors found to be associated with CVI include age, sex, a family history of varicose veins, obesity, pregnancy, phlebitis, and previous leg injury. 5,6 There also may be environmental or behavioral factors associated with CVI such as prolonged standing and perhaps a sitting posture at work. 6,7 Varicose veins have a significant impact on healthcare resources, with millions of people seeking medical attention for their cosmetic appearance annually. Although often minimized, the cosmetic consequences may adversely affect an individual's quality of life and are associated with other manifestations.The more serious consequences of CVI such as venous ulcers have an estimated prevalence of Ϸ0.3%, although active or healed ulcers are seen in Ϸ1% of the adult population. 8 It has been estimated that Ϸ2.5 million people have CVI in the United States, and of those, Ϸ20% develop venous ulcers. 9 The ov...

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Efficacy of Sclerotherapy in Varicose Veins—A Prospective, Blinded, Placebo-Controlled Study

Cited by 24 publications

References 19 publications

Effectiveness of foam sclerotherapy for the treatment of varicose veins

Effectiveness of foam sclerotherapy for the treatment of varicose veins

Chronic Venous Insufficiency

Chronic Venous Insufficiency

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