Efficacy of Sharbat-e-Afsanteen (Artemisia absinthium L.) on altered liver enzymes among alcoholics – A randomized single-blind controlled clinical trial

Fatima, Nazreen; Siddiqui, Mohammad Akhtar; Riyazuddin, Mohd.; Shahid, Abia

doi:10.1016/j.hermed.2023.100623

Cited by 1 publication

(2 citation statements)

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“…25,26 Recent clinical studies have shown that A. absinthium can effectively improve liver function in patients with alcoholic liver disease, and its pharmacological mechanism of action can be attributed to hepatoprotective and anti-inflammatory effects. 27 Many studies have reported that essential oils, sesquiterpenoids, flavonoids, and phenolics are the main bioactive components of A. absinthium, and several studies have shown a positive correlation between the total phenolic content of A. absinthium extracts and their antioxidant and anticancer activities. 14,[28][29][30][31] However, there is a lack of research on the quality control of A. absinthium.…”

Section: Introductionmentioning

confidence: 99%

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Exploring anti‐inflammatory and antioxidant‐related quality markers of Artemisia absinthium L. based on spectrum–effect relationship

Wubuli,

Abdulla,

Zhao

et al. 2024

Phytochemical Analysis

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IntroductionArtemisia absinthium L. is a well‐known medicinal, aromatic, and edible plant with important medicinal and economic properties and a long history of use in treating liver inflammation and other diseases; however, there has been insufficient progress in quality control.ObjectiveThis study aimed to investigate the quality markers for the anti‐inflammatory and antioxidant activities of A. absinthium based on spectrum–effect relationship analysis.Materials and methodsEighteen batches of A. absinthium from different origins were used. Chemical fingerprints were obtained by ultra‐performance liquid chromatography (UPLC). The chemical compositions were identified by quadrupole‐Orbitrap high‐resolution mass spectrometry. Anti‐inflammatory activity was assessed by inhibition of cyclooxygenase‐2 and 15‐lipoxygenase in vitro and inhibition of nitric oxide release in lipopolysaccharide‐induced BV‐2 cells. Antioxidant activity was assessed by DPPH and ABTS radical scavenging assays. The relationship between bioactivity and chemical fingerprints was then analyzed using chemometrics including gray relational analysis, bivariate correlation analysis, and orthogonal partial least squares analysis.ResultsDifferent batches of A. absinthium extracts possessed significant anti‐inflammatory and antioxidant activities to varying degrees. Eighty compounds were identified from A. absinthium, and 12 main common peaks were obtained from the UPLC fingerprints. P3 (chlorogenic acid), P5 (isochlorogenic acid A), and P6 (isochlorogenic acid C) were screened as the most promising active compounds by correlation analysis and further validated for their remarkable anti‐inflammatory effects.ConclusionThis is the first study to screen the quality markers of A. absinthium by establishing the spectrum–effect relationship, which can provide a reference for the development of quality standards and further research on A. absinthium.

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Section: Introductionmentioning

confidence: 99%

“…These pathways contribute to the overall inflammatory response in the body 25,26 . Recent clinical studies have shown that A. absinthium can effectively improve liver function in patients with alcoholic liver disease, and its pharmacological mechanism of action can be attributed to hepatoprotective and anti‐inflammatory effects 27 …”

Section: Introductionmentioning

confidence: 99%