Efficacy of Silver-Loaded Nanofiber Dressings in Candida albicans–Contaminated Full-Skin Thickness Rat Burn Wounds

Çiloğlu, Nesibe Sinem; Mert, Ayşe İrem; Doğan, Zarife; Demir, Ali; Cevan, Simin; Aksaray, Sebahat; Tercan, Mustafa

doi:10.1097/bcr.0b013e3182aa7143

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Their results showed that the composite system exhibited antibacterial activity against Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus . Silver‐loaded dressings have also been reported as effective against nonbacterial targets, including fungi .…”

Section: Drug‐containing (Delivery) Dressingsmentioning

confidence: 99%

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Boateng

Catanzano

2015

Journal of Pharmaceutical Sciences

712

473

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Advanced therapeutic dressings that take active part in wound healing to achieve rapid and complete healing of chronic wounds is of current research interest. There is a desire for novel strategies to achieve expeditious wound healing due to the enormous financial burden worldwide. This paper reviews the current state of wound healing and wound management products, with emphasis on the demand for more advanced forms of wound therapy and some of the current challenges and driving forces behind this demand. The paper reviews information mainly from peer reviewed literature and other publicly available sources such as the FDA. A major focus is the treatment of chronic wounds including amputations, diabetic and leg ulcers, pressure sores, surgical and traumatic wounds (e.g. accidents and burns) where patient immunity is low and the risk of infections and complications are high. The main dressings include medicated moist dressings, tissue engineered substitutes, biomaterials based biological dressings, biological and naturally derived dressings, medicated sutures and various combinations of the above classes. Finally, the review briefly discusses possible prospects of advanced wound healing including some of the emerging approaches such as hyperbaric oxygen, negative pressure wound therapy and laser wound healing, in routine clinical care.3

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Section: Drug‐containing (Delivery) Dressingsmentioning

confidence: 99%

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Boateng

Catanzano

2015

Journal of Pharmaceutical Sciences

712

473

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“…Silver has also been found to be toxic against nonbacterial targets such as fungi. Nanofiber dressing loaded with 1% silver is used to treat fungi‐contaminated burn wounds 105 . However, the results were not statistically significant, authors presumed that it was due to the low concentration of silver loaded in the dressing compared with commercial products in the market.…”

Section: Bioactive Moleculesmentioning

confidence: 99%

A review of current advancements for wound healing: Biomaterial applications and medical devices

2022

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Wound healing is a complex process that is critical in restoring the skin's barrier function. This process can be interrupted by numerous diseases resulting in chronic wounds that represent a major medical burden. Such wounds fail to follow the stages of healing and are often complicated by a pro‐inflammatory milieu attributed to increased proteinases, hypoxia, and bacterial accumulation. The comprehensive treatment of chronic wounds is still regarded as a significant unmet medical need due to the complex symptoms caused by the metabolic disorder of the wound microenvironment. As a result, several advanced medical devices, such as wound dressings, wearable wound monitors, negative pressure wound therapy devices, and surgical sutures, have been developed to correct the chronic wound environment and achieve skin tissue regeneration. Most medical devices encompass a wide range of products containing natural (e.g., chitosan, keratin, casein, collagen, hyaluronic acid, alginate, and silk fibroin) and synthetic (e.g., polyvinyl alcohol, polyethylene glycol, poly[lactic‐co‐glycolic acid], polycaprolactone, polylactic acid) polymers, as well as bioactive molecules (e.g., chemical drugs, silver, growth factors, stem cells, and plant compounds). This review addresses these medical devices with a focus on biomaterials and applications, aiming to deliver a critical theoretical reference for further research on chronic wound healing.

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“…Silver-coated dressings and Nystatin have proven to be effective treatments (Acar et al, 2011 ). Electrospun SSD-containing nanofiber dressings were also shown to be effective against C. albicans infected burn eschar (Ciloglu et al, 2014 ). In many burn centers, systemic administration of Amphotericin B is used when invasive fungal infection is suspected; however, systemic administration of Amphotericin B is associated with a dose-dependent nephrotoxic effect (Hamill, 2013 ).…”

Section: Inflammationmentioning

confidence: 99%

Advancements in Regenerative Strategies Through the Continuum of Burn Care

et al. 2018

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Burns are caused by several mechanisms including flame, scald, chemical, electrical, and ionizing and non-ionizing radiation. Approximately half a million burn cases are registered annually, of which 40 thousand patients are hospitalized and receive definitive treatment. Burn care is very resource intensive as the treatment regimens and length of hospitalization are substantial. Burn wounds are classified based on depth as superficial (first degree), partial-thickness (second degree), or full-thickness (third degree), which determines the treatment necessary for successful healing. The goal of burn wound care is to fully restore the barrier function of the tissue as quickly as possible while minimizing infection, scarring, and contracture. The aim of this review is to highlight how tissue engineering and regenerative medicine strategies are being used to address the unique challenges of burn wound healing and define the current gaps in care for both partial- and full-thickness burn injuries. This review will present the current standard of care (SOC) and provide information on various treatment options that have been tested pre-clinically or are currently in clinical trials. Due to the complexity of burn wound healing compared to other skin injuries, burn specific treatment regimens must be developed. Recently, tissue engineering and regenerative medicine strategies have been developed to improve skin regeneration that can restore normal skin physiology and limit adverse outcomes, such as infection, delayed re-epithelialization, and scarring. Our emphasis will be centered on how current clinical and pre-clinical research of pharmacological agents, biomaterials, and cellular-based therapies can be applied throughout the continuum of burn care by targeting the stages of wound healing: hemostasis, inflammation, cell proliferation, and matrix remodeling.

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Efficacy of Silver-Loaded Nanofiber Dressings in Candida albicans–Contaminated Full-Skin Thickness Rat Burn Wounds

Cited by 6 publications

References 16 publications

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

Advanced Therapeutic Dressings for Effective Wound Healing—A Review

A review of current advancements for wound healing: Biomaterial applications and medical devices

Advancements in Regenerative Strategies Through the Continuum of Burn Care

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