Efficacy of Simvastatin and Pumpkin-Seed Oil in the Management of Dietary-Induced Hypercholesterolemia

al-Zuhair, H; El-Fattah, Amal Ahmed Abd; Latif, Hekma A. Abd El

doi:10.1006/phrs.1997.0148

Cited by 53 publications

(30 citation statements)

References 43 publications

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“…Animal studies have also shown that pumpkin seed oil can retard the progression of hypertension and reduce hypercholesterolemia (Al-Zuhair, Abdel-Fattah, & Abd el Latif, 1997) and arthritis (Fahim, Abdel-Fattah, Agha, & Gad, 1995). Treatment of spontaneously hypertensive rats with felodipine or captopril monotherapy or combined with pumpkin seed oil produced improvement in the measured free radical scavengers in the heart and kidney (AlZuhair, Abdel-Fattah, & El-Sayed, 2000).…”

Section: Introductionmentioning

confidence: 94%

Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts

Xanthopoulou

Nomikos

Fragopoulou

et al. 2009

Food Research International

144

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Section: Introductionmentioning

confidence: 94%

Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts

Xanthopoulou

Nomikos

Fragopoulou

et al. 2009

Food Research International

144

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“…Although the whole mechanisms are still unclear, it is worthy to further investigate the effects of PSO. Since PSO also exerts the ability to control serum lipid levels and blood pressure, it is suitable for elderly men with BPH and simultaneous cardiovascular disease [22,23] . To enhance the treatment effect, Phytosterol-F is added to PSO to increase the proportion of phytosterol.…”

Section: Discussionmentioning

confidence: 99%

Pumpkin Seed Oil and Phytosterol-F Can Block Testosterone/Prazosin-Induced Prostate Growth in Rats

Tsai

Tong²,

Cheng

et al. 2006

Urol Int

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Introduction: This study was undertaken to investigate the effects of pumpkin seed oil alone or combined with Phytosterol-F on testosterone/prazosin-induced (T-P) prostate growth in rats. Materials and Methods: Forty adult Wistar rats were divided into five groups, including: one control group, rats treated with vehicle only, one group treated with T-P, and two groups of T-P-treated rats, one receiving orally pumpkin seed oil alone and one group receiving orally pumpkin seed oil combined with Phytosterol-F. Two weeks later, the prostatic weight-to-body weight ratio was determined after sacrifice. The total protein concentration was measured by using a protein assay. Some ventral prostatic tissues were histologically examined after hematoxylin-eosin staining. Results: Histological sections of the ventral prostate showed that the architecture of the prostate glands became hyperplastic in the T-P rats, but not in the control or vehicle-treated animals. As compared with the control or vehicle group, T-P rats had a significantly higher prostatic weight-to-body weight ratio for the ventral prostate (p = 0.05 and p = 0.007, respectively), but not for the dorsolateral prostate (p = 0.53 and p = 0.73, respectively). The T-P rats had significantly higher protein levels within both lobes (ventral lobe, p = 0.02 and p < 0.0001, respectively; dorsolateral lobe, p = 0.06 and p = 0.005, respectively). As compared with the T-P-alone rats, the TP rats treated with pumpkin seed oil alone or pumpkin seed oil combined with Phytosterol-F had a significantly lower weight ratio for the ventral prostate (p = 0.01 and p = 0.004, respectively) and significantly lower protein levels within both lobes (p = 0.03 and p = 0.003, respectively; p = 0.007 and p = 0.002, respectively). In addition, Phytosterol-F had some additive effect on the total protein synthesis within the ventral prostate (p = 0.02). Conclusion: Pumpkin seed oil alone or combined with Phytosterol-F can block the T-P-induced increases in prostatic weight-to-body weight ratio and protein synthesis.

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“…It was found that pumpkin polysaccharide could increase the SOD and GSH-Px activity and reduce the MDA content in tumormice serum (P < 0.05) [92]. It was reported that pumpkinseed oil was effective against hypercholesterolemia [93].…”

Section: Hypocholesterolemic and Anti-oxidant Potentialmentioning

confidence: 99%

A Review on Pharmacological Activities and Utilization Technologies of Pumpkin

Chen

Huan

2006

Plant Foods Hum Nutr

326

203

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Dietary plants and herbal preparations have been traditionally used as medicine in developing countries and obtained a resurgence of use in the United States and Europe. Research carried out in last few decades has validated several such claims of use of traditional medicine plants. Popularity of pumpkin in various systems of traditional medicine for several ailments (antidiabetic, antihypertensive, antitumor, immunomodulation, antibacterial, antihypercholesterolemia, intestinal antiparasitia, antiinflammation, antalgic) focused the investigators' attention on this plant. Considerable evidence from several epidemiological studies concerning bioactivities leads have stimulated a number of animal model, cell culture studies and clinical trials designed to test this pharmacological actions. In addition, it was found that technologies such as germination and fermentation could reduce antinutritional materials and affect the pharmacological activities of pumpkin. This review will focus on the main medicinal properties and technologies of pumpkin, and point out areas for future research to further elucidate mechanisms whereby this compound may reduce disease risk.

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Efficacy of Simvastatin and Pumpkin-Seed Oil in the Management of Dietary-Induced Hypercholesterolemia

Cited by 53 publications

References 43 publications

Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts

Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts

Pumpkin Seed Oil and Phytosterol-F Can Block Testosterone/Prazosin-Induced Prostate Growth in Rats

A Review on Pharmacological Activities and Utilization Technologies of Pumpkin

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