Efficacy of Single Dose of 500 mg Mebendazole on Geohelminths amongst School Age Children in Bafoussam, Cameroon

Payne, Vincent Khan; Megwi, Leonelle; Noubom, Michel; Cédric, Yamssi; Ngangnang, Ghislain R.; Mbida, Mpoame; Felix, Bilong Bilong Charles

doi:10.9734/bmrj/2016/19506

Cited by 8 publications

(8 citation statements)

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“…A. lumbricoides had the highest mean intensity (3691.12 ± 3898.47) among the nematodes recorded in the study. This is in line with the results of [ 45 ]. The mean intensity of A. lumbricoides recorded was higher as compared to the results obtained by [ 18 ] who obtained 2594.44 ± 3897.174 and slightly lower than that obtained by [ 17 ] who registered 3722 ± 5677 for A. lumbricoides .…”

Section: Discussionsupporting

confidence: 93%

Gastrointestinal Nematodes among Residents in Melong, Moungo Division, Littoral Region, Cameroon

Cédric

Nadia

Payne

et al. 2021

BioMed Research International

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Background. Intestinal parasitic infections are among the most common infections worldwide. The present study was undertaken to provide baseline information on the status of gastrointestinal nematodes in Melong Subdivision, Moungo Division, Littoral Region, Cameroon. Material and Methods. Seven hundred and eighty-eight stool samples were collected in randomly selected quarters in the community of Melong. These stool samples were brought to the Laboratory of Applied Biology and Ecology in the University of Dschang for analysis using the qualitative (simple flotation) and quantitative (Mc Master count) technique. Results. The nematodes identified were Ascaris lumbricoides, hookworm, Trichuris trichiura, and Capillaria hepatica with respective prevalences and intensities of infection of 2.2% and 3691.12 ± 3898.47 , 1.4% and 940.91 ± 1825.90 , 1.0% and 193.75 ± 227.47 , and 0.4%and 50 ± 00 . The data on the prevalence of nematodes with respect to sex and age showed that females (6.0%) were more infected than males (2.76%) with no significant difference ( P > 0.05 ). Furthermore, with respect to age, adults were more infected than children. The percentage of educational level showed a reduction in the number of parasites in the higher educational level. The prevalence of A. lumbricoides between localities showed a significant difference ( P < 0.05 ) with “Quarter 1” harboring most of the nematodes. Cases of double (Ascaris lumbricoides + Trichuris trichiura) and triple (Ascaris lumbricoides + Trichuris trichiura + hookworm) parasitism were encountered with both having a prevalence of 0.3%. According to the fecal concentration of eggs, 63.89% of the infections were light, 5.56% moderate, and 30.56% heavy. Conclusion. A relatively low overall prevalence was obtained in our study, showing that the national deworming campaign is proving effective, but more effort is needed to completely eradicate these parasites for a single infected individual can cause havoc.

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Section: Discussionsupporting

confidence: 93%

Gastrointestinal Nematodes among Residents in Melong, Moungo Division, Littoral Region, Cameroon

Cédric

Nadia

Payne

et al. 2021

BioMed Research International

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“…The observed CR for single dose mebendazole in this study was in line with results from RCTs conducted in terms of CR in china (31%)in Vietnam (38%) (20,24), and ERR in line from RCTs conducted in Tanzania (ERR = 68%) (16). However, it is considerably lower than from other RCT studies conducted in terms of CR in Tanzania (95.4%), and in Cameron(70.4%) (33,34), whereas in terms of ERR in collaboration of six endemic countries (79.6%), Cameron (77%), and PDR (76.3%) (18,26,33). On the other hand it is higher than a RCT study reported in terms CR in Tanzania (13%), Zanzibar (7.6%), Tanzania (24.4), and PDR (17.6%) (16,18,19,35).…”

Section: Discussionsupporting

confidence: 88%

Efficacy of a Single Dose versus Triple Dose Regimen of Mebendazole against Hookworm Infection among School Children: A Randomized, Single blinded Trial.

Eshetu

Aemero

Jejaw

2019

Preprint

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Background: The current control efforts against soil transmitted helminthic infection focused on reducing morbidity and transmission potential through periodic anthelminthic chemotherapy of single dose of mebendazole and albendazole regimen. Single dose mebendazole is one of extensively applicable drug regimen as a preventive chemotherapy in hookworm endemic areas. However, nowadays, studies reveal single dose treatment regimen has poor and unsatisfactory efficacy status against hookworm infection. We evaluated the efficacy status of single dose (500mg) versus triple dose (100mg) of mebendazole against hookworm infection among school aged children.Methods: This randomized, single-blinded clinical trial took place in a primary school on Burie and Debre Elias towns, Northwest Ethiopia among school-aged children (6-14). Using simple randomization, eligible hookworm positive children were randomly allocated (1:1) to either a single dose or triple dose of mebendazole arm. Stool samples were collected at baseline and follow-up period (14-21 days after treatment) for McMaster analysis. The primary and secondary outcome measures in this study were cure rate (CR) and egg reduction rate (ERR), respectively. Results were displayed using tables and figure. Independent t test was used to compare group means, logistic regression was used to calculate odds ratio (OR), and P-value < 0.05 at 95% CI was considered for statistical significance.Result: 109 children were allocated for each treatment arm and 103 children were completed the drug efficacy follow up study. Cure rate against hookworm was significantly higher in triple dose (96.1%) than in single dose (30.8%) with (OR=55.125; 95% CI: 11.92-254.9; P < 0.001). Egg reduction rate against hookworm infection in triple dose (99.5%) was also significantly higher than single dose (68.9%) with difference t (101) =5.38; 95% CI 230.95-505.36; P < 0.001.Conclusion: Single dose regimen of mebendazole for the treatment of hookworm infection showed poor efficacy, while triple dose revealed satisfactory efficacy. Therefore, we recommend for giving special emphasis on current deworming program which implemented through single dose mebendazole for hookworm endemic area.

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“…This is in line with studies conducted in China (CR = 29%) [14], Vietnam (CR = 38% & ERR = 52%) [19], and Tanzania (CR = 24.4 & ERR = 59.5%) [32]. However, it does not agree with other studies conducted in Zanzibar (CR = 7.6%) [28], Tanzania (CR = 13%) [18], Lao PDR (CR = 17.6% & ERR = 76.3%) [33], and Cameroon (CR = 70.3%) [31]. The above mentioned reasons could also have resulted in the discrepancies.…”

Section: Discussionmentioning

confidence: 66%

“…Studies have been conducted to assess the efficacy of the single dose of mebendazole on hookworm infections [14,18,19,28,[31][32][33]. Overall, their CRs ranged from 7.6 to 70.3% and ERRs ranged from 52 to 76.3%.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a single dose versus a multiple dose regimen of Mebendazole against hookworm infections among school children: a randomized open-label trial

2020

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Background: Despite the existence of a population-based control program using single dose albendazole or mebendazole as a preventive chemotherapy, hookworm transmission remains high. It causes a negative impact on the growth and school performance of children. In connection to this preventive chemotherapy, different studies produced conflicting results. This study aimed at evaluating the efficacy of single (500 mg) versus multiple doses (100 mg twice a day during three consecutive days) of mebendazole against hookworm infections among schoolaged children. Methods: This randomized open-label clinical trial took place among school-aged children (6-14 years old) in Burie and Debre Elias towns, Northwest Ethiopia. Using simple randomization, eligible hookworm-positive children were allocated (1:1) to either a single or multiple dose treatment arms. Stool samples were collected and processed using McMaster method at baseline and follow-up period (14-21 days after treatment). Only laboratory technicians were blinded. The cure and egg reduction rates were the primary and secondary therapeutic outcome measures against hookworm infections, respectively. An independent t-test was used to compare group means, and logistic regression was used to calculate odds ratio (OR). P-value < 0.05 at 95% CI was considered statistically significant. Result: One hundred eight children, 54 in each treatment arm had completed baseline data and received allocated treatment. One hundred three children had completed follow-up data records and included for the final efficacy analysis. Cure rate against hookworm was significantly higher in the multiple dose (96.1%) than in the single dose (30.8%) with OR = 55.125; 95% CI: 11.92-254.9; P < 0.001. The egg reduction rate in the multiple dose treatment arm (99.5%) was also significantly higher than in the single dose arm (68.9%) with difference t (101) =5.38; 95% CI 230.95-505.36; P < 0.001. Conclusion: The single dose regimen of mebendazole for the treatment of hookworm infections showed poor cure and egg reduction rates, while the multiple doses revealed satisfactory. Although multiple dose regimen administration is a bit more complex than the single dose, we strongly encourage replacing it with multiple dose regimen during deworming programs in hookworm endemic areas.

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Efficacy of Single Dose of 500 mg Mebendazole on Geohelminths amongst School Age Children in Bafoussam, Cameroon

Cited by 8 publications

References 0 publications

Gastrointestinal Nematodes among Residents in Melong, Moungo Division, Littoral Region, Cameroon

Gastrointestinal Nematodes among Residents in Melong, Moungo Division, Littoral Region, Cameroon

Efficacy of a Single Dose versus Triple Dose Regimen of Mebendazole against Hookworm Infection among School Children: A Randomized, Single blinded Trial.

Efficacy of a single dose versus a multiple dose regimen of Mebendazole against hookworm infections among school children: a randomized open-label trial

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