In this study the efficacy of traditional treatments as hot water, chlorine alone or in combination with microbubbles on melon was investigated. Different treatments were used like hot water (55 °C, 2 and 5 min); chlorine (150 ppm, 2 and 5 min); ozone microbubbles (150 ppm, 2 and 5 min); hot water microbubbles (55 °C, 2 and 5 min); chlorine microbubbles (150 ppm, 2 and 5 min). Microbial populations were evaluated at days 0 and 4 of the shelf-life. After washing, ozone microbubbles for 5 min and hot water microbubbles for 2 or 5 min were the most effective treatments causing 2.3, 2 and 1.7 log reductions, in the number of mesophilic aerobes, respectively. Throughout 4 days of shelf-life, hot water microbubbles for 2 or 5 min and ozone microbubbles for 5 min were more effective in retarding the microbial growth than the other treatments. The results showed that microbubbles could be a promising method for controlling the microbial quality of melon or other produces with the necessity of further elucidations.