Efficacy of Sucralfate in the Early Postoperative Improvement of Pediatric Thermal Welding Adenotonsillectomy Morbidity

Abstract

Objective: Many surgical techniques and solutions have tried to improve the morbidity of pediatric adenotonsillectomy. Pain is mainly treated with analgesics, steroids and anaesthetics. However, various topical solutions such as sucralfate have been used for pain relief. Methods: We investigated the efficacy of sucralfate together with the TW technique on post-tonsillectomy morbidity in children. Our hypothesis was that the advantages of the TW technique might be improved by the protective coating effect of sucralfate on post-tonsillectomy morbidity. Patients were examined and scored clinically by their parents on the day of the operation and at the end of the day for the next 7 days. Throat pain was estimated by parents using the Faces Pain Scale-Revised from 0 to 10 with 0 representing the absence of pain and 10 maximal pain on postoperative days 1 to 7 while swallowing, speaking and resting. Results: The daily pain scores over the entire 7-day postoperative period were consistently lower in the sucralfate group than in the placebo group. The reduction of throat pain was significantly lower in the sucralfate group compared to the placebo group from the 1 st to the 3 rd postoperative day. Conclusion: Our study demonstrates that sucralfate is safe and improves post-tonsillectomy analgesia in combination with the TW technique in children.

The efficacy of topical sucralfate in improving pain and wound healing after haemorrhoidectomy procedure: A systematic review, meta‐analysis, and meta‐regression of randomised clinical trials

“…Sucralfate has been shown to have analgesic properties in various conditions. The primary action of sucralfate is idiopathic; meanwhile, several studies showed the effect of sucralfate 46,47 . Aside from the anti‐peptic effect, sucralfate increases angiogenesis and the bioavailability of growth factors, including fibroblast growth factor (FGF), epidermal growth factor (EGF), and tissue growth factor (TGF); thus, it enhances epithelialization and mucosal protection resulting in the reduction of pain and improving wound healing 36,48,49 .…”

“…The primary action of sucralfate is idiopathic; meanwhile, several studies showed the effect of sucralfate. 46 , 47 Aside from the anti‐peptic effect, sucralfate increases angiogenesis and the bioavailability of growth factors, including fibroblast growth factor (FGF), epidermal growth factor (EGF), and tissue growth factor (TGF); thus, it enhances epithelialization and mucosal protection resulting in the reduction of pain and improving wound healing. 36 , 48 , 49 In conjunction with the pharmacodynamics of sucralfate, this study demonstrated linear results in which sucralfate is beneficial and significantly improves pain and wound healing.…”

“…The primary action of sucralfate is idiopathic; meanwhile, several studies showed the effect of sucralfate. 46,47 Aside from the anti-peptic effect, sucralfate…”