Efficacy of tamsulosin hydrochloride in relieving “double-J ureteral stent-related morbidity”: a randomized placebo controlled clinical study

Tripathy, Sambit; Agrawal, Vivek

doi:10.1007/s11255-014-0825-8

Cited by 18 publications

(19 citation statements)

References 14 publications

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“…29 Singh I et al, in their study found that tamsulosin group had significant decrease in urinary index score, pain index score, work performance score, average VAS score. 30 Similarly, Wang CJ et al, and Dellis AE et al, in their studies found significant improvement in stent related symptoms with tamsulosin. 31,32 In our study, tamsulosin was found to be very effective in reducing Mean urinary symptoms index.…”

Section: Resultsmentioning

confidence: 86%

“…Tamsulosin, acts as a selective -1a/1d blocker, decreases ureteric spasm, bladder outlet resistance and voiding pressure, hence decreases voiding symptoms and urinary reflux. [21][22][23][24][25][26][27][28][29][30][31][32] Phosphodiesterase-5 (PDE-5) receptors are present in urinary bladder, prostate, proximal urethra, ureter and PDE-5 inhibitors lead to smooth muscles relaxation in these organs. Tadalafil, a PDE-5 inhibitor, has proven its efficacy in erectile dysfunction and relieving BPH related lower urinary tract symptoms (LUTS).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of tadalafil in ureteric stent related symptoms: a double blind, prospective, randomised study

Chauhan¹,

Singla²,

Dumra³

et al. 2019

Int J Res Med Sci

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Background: Is tadalafil effective and safe in ureteric stent related symptoms? The objective of this trial is to study the efficacy and safety of tadalafil and compare it with tamsulosin in relieving ureteric stent related symptoms by using ureteral stent symptom questionnaire.Methods: Total 144 patients with dj stent symptoms were randomized into two groups with 72 patients in each. Group A patients were given tadalafil 5mg and Group B, tamsulosin 0.4mg for 2 weeks. Ureteral stent symptom questionnaire was filled on 7th day and on 21st day after stent insertion. Statistically significant difference between groups was determined by the t-test, Mann-Whitney U-test, Pearson Chi-square test or Fisher's exact test. Comparison between quantitative time related variables was done by Wilcoxon Signed Rank test. All the statistical tests were two-sided and were performed at a significance level of α=.05.Results: Tamsulosin was found more effective then tadalafil in decreasing mean urinary index (p=0.004). Tadalafil caused significant decrease in body pain (p=0.006) and improvement in general health index score, work performance and sex score (P value= 0.041, <0.001 and <0.015 respectively) as compared to tamsulosin. Additional problems score improvement and analgesic use were found comparable in 2 groups (p value =0.193, 0.070 respectively). Adverse effect with both the drugs were minimal, mild to moderate and self-limiting.Conclusions: Tadalafil found more effective then Tamsulosin in relieving body pain, sexual symptoms and improving general health and work performance but less effective in improvement of urinary symptoms.

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Section: Resultsmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of tadalafil in ureteric stent related symptoms: a double blind, prospective, randomised study

Chauhan¹,

Singla²,

Dumra³

et al. 2019

Int J Res Med Sci

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“…More recently, Singh et al . 23 showed that tamsulosin 0.4 mg had positive effects on urinary index and pain index scores in a small RCT (n = 60).…”

Section: Discussionmentioning

confidence: 96%

Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study

Lee

Cho

et al. 2017

Sci Rep

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To evaluate the effect of naftopidil 75 mg once daily for ureteral double-J (DJ) stent-related discomfort after a ureteroscopic procedure using a multicenter, randomized, double-blinded, placebo-controlled study. 100 patients with indwelled retrograde DJ ureteral stents after ureteroscopic stone removal or retrograde intrarenal surgery (RIRS) were randomized 1:1 to receive either placebo or naftopidil during the stenting period. At the time of stent removal, the Ureteral Stent Symptom Questionnaire (USSQ), the International Prostate Symptom Score and the total amount of used analgesics were reported. Of the 92 patients who completed the study, 49 patients were enrolled in the placebo group, and 43 patients in the naftopidil group. USSQ urinary symptom scores (30.90 vs. 29.23, p = 0.299) and USSQ body pain scores (22.28 vs. 19.58, respectively, p = 0.286) were lower in the naftopidil group than in the placebo group, but the difference was not significant. Multivariate analysis showed that the use of a ureteral access sheath during RIRS was the only significant predictor of postoperative DJ-related pain (OR = 2.736, p = 0.031). The use of naftopidil once daily did not significantly reduce DJ ureteral stent-related discomfort. Larger-scaled prospective studies should be conducted to evaluate the effects of naftopidil on DJ stent-related symptoms and surgeries.

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“…The cost of saving and increased comfort should be weighed against the potential for severe post-discharge complications. Alpha-blockers effectively reduced the morbidity of ureteral stents [45,46]. A meta-analysis showed that, tamsulosin and alfuzosin, which were the most commonly applied drugs, had the similar function to relief the stents-related discomfort [47].…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Stenting versus Non-Stenting for the Treatment of Ureteral Stones

Wang

Man

et al. 2017

PLoS ONE

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Background and aimUreteroscopic lithotripsy (URL) and extracorporeal shock wave lithotripsy (ESWL) are two widely used methods for the treatment of ureteral stones. The need for ureteral stenting during these procedures is controversial. In this meta-analysis, we evaluated the benefits and disadvantages of ureteral stents for the treatment of ureteral stones.MethodsDatabases including PubMed, Embase and Cochrane library were selected for systematic review of randomized controlled trials (RCTs) comparing outcomes with or without stenting during URL and ESWL. Meta-analysis was performed using RevMan 5.3 and STATA 13.0 software.ResultsWe identified 22 RCTs comparing stenting and non-stenting. The stented group was associated with longer operation time (WMD: 4.93; 95% CI: 2.07 to 7.84; p < 0.001), lower stone-free rate (OR: 0.55; 95% CI: 0.34 to 0.89; p = 0.01). In terms of complications, the incidence of hematuria (OR: 3.68; 95% CI: 1.86 to 7.29; p < 0.001), irritative urinary symptoms (OR: 4.40; 95% CI: 2.19 to 9.10; p < 0.001), urinary infection (OR: 2.23; 95% CI: 1.57 to 3.19; p < 0.001), and dysuria (OR: 3.90; 95% CI: 2.51 to 6.07; p < 0.001) were significantly higher in the stented group. No significant differences in visual analogue score (VAS), stricture formation, fever, or hospital stay were found between stenting and non-stenting groups. The risk of unplanned readmissions (OR: 0.63; 95% CI: 0.41 to 0.97; p = 0.04) was higher in the non-stented group.ConclusionsOur analysis showed that stenting failed to improve the stone-free rate, and instead, it resulted in additional complications. However, ureteral stents are valuable in preventing unplanned re-hospitalization. Additional randomized controlled trials are still required to corroborate our findings.

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Efficacy of tamsulosin hydrochloride in relieving “double-J ureteral stent-related morbidity”: a randomized placebo controlled clinical study

Cited by 18 publications

References 14 publications

Efficacy and safety of tadalafil in ureteric stent related symptoms: a double blind, prospective, randomised study

Efficacy and safety of tadalafil in ureteric stent related symptoms: a double blind, prospective, randomised study

Effects of naftopidil on double-J stent-related discomfort: a multicenter, randomized, double-blinded, placebo-controlled study

Meta-Analysis of Stenting versus Non-Stenting for the Treatment of Ureteral Stones

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