Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

Wang, Shuai; Luo, Sean X.; Jie, Jing; Li, Dan; Liu, Han; Song, Lei

doi:10.3389/fphar.2022.946554

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…Acute lung injury (ALI) is an acute inflammatory condition often triggered by severe infection or trauma. It is characterized by difficulty in breathing, respiratory distress, and damage to the alveolar epithelial barrier (1,2). The primary pathological features include acute widespread alveolar damage, pulmonary interstitial fluid accumulation, heightened pulmonary capillary permeability, and excessive inflammation (3,4).…”

Section: Introductionmentioning

confidence: 99%

Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation

Tang,

Liang,

Wang

et al. 2023

Front. Immunol.

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Acute lung injury (ALI) is a common condition, particularly in the COVID-19 pandemic, which is distinguished by sudden onset of respiratory insufficiency with tachypnea, oxygen-refractory cyanosis, reduced lung compliance and diffuse infiltration of pulmonary alveoli. It is well-established that increasing activity of toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling axis and the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation are associated with the pathogenesis of ALI. Since ALI poses a huge challenge to human health, it is urgent to tackle this affliction with therapeutic intervention. Qinhuo Shanggan oral solution (QHSG), a traditional Chinese herbal formula, is clinically used for effective medication of various lung diseases including ALI, with the action mechanism obscure. In the present study, with the rat model of lipopolysaccharide (LPS)-induced ALI, QHSG was unveiled to ameliorate ALI by alleviating the pathological features, reversing the alteration in white blood cell profile and impeding the production of inflammatory cytokines through down-regulation of TLR4/NF-κB signaling cascade and inhibition of NLRP3 inflammasome activation. In LPS-stimulated RAW264.7 mouse macrophages, QHSG was discovered to hinder the generation of inflammatory cytokines by lessening TLR4/NF-κB signaling pathway activity and weakening NLRP3 inflammasome activation. Taken together, QHSG may resolve acute lung injury, attributed to its anti-inflammation and immunoregulation by attenuation of TLR4/NF-κB signaling cascade and inhibition of NLRP3 inflammasome activation. Our findings provide a novel insight into the action mechanism of QHSG and lay a mechanistic foundation for therapeutic intervention in acute lung injury with QHSG in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation

Tang,

Liang,

Wang

et al. 2023

Front. Immunol.

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Preclinical Evaluation of Protective Effects of Terpenoids Against Nanomaterial‐Induced Toxicity: A Meta‐Analysis

Sun,

Zhou,

Xie

et al. 2024

J of Applied Toxicology

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Terpenoids, the largest class of natural products, have been demonstrated to confer antioxidant, anti‐inflammatory, anti‐apoptotic, and antitumor activities. However, whether terpenoids benefit populations exposed to nanomaterials through these mechanisms remains unclear. This meta‐analysis was to evaluate the effects of terpenoids in preclinical models with nanomaterial exposure. Electronic database searching identified 39 studies. The meta‐analysis by Stata 15.0 showed that terpenoid supplementation significantly improved cell viability and altered oxidative stress (decreased ROS, NO, MDA, and TOC and increased SOD, CAT, GPx, GSH, GSH‐Px, and TAC)–, inflammation (decreased IL‐6, IL‐1β, TNF‐α, NF‐κB, monocytes, and increased IL‐10)–, apoptosis (reduced Bax, caspase‐3, caspase‐9, P53, and elevated Bcl‐2)–, genotoxic (reduced tail length, % tail DNA, tail moment, DNA fragmentation, chromosomal aberration, and MNPCEs)–, liver function (reduced ALT, AST, and ALP)–, renal function (reduced creatinine, urea, and uric acid)–, reproductive function (increased sperm count, testosterone, Johnsen's score, and number of progeny)–, lipid profile (lower cholesterol, TG, LDL, and higher HDL)–, and carcinogenesis (downregulated AFP and CEA)–related biomarkers induced by nanomaterials. Subgroup analysis indicated that monoterpenoids and tetraterpenoids were particularly effective. Collectively, terpenoids may be a promising candidate for prevention of toxicities caused by nanomaterials.

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EGR-1 Contributes to Pulmonary Edema by Regulating the Epithelial Sodium Channel in Lipopolysaccharide-Induced Acute Lung Injury

Wang,

Ma,

et al. 2023

Immunological Investigations

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Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies

Cited by 3 publications

References 57 publications

Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation

Qinhuo Shanggan oral solution resolves acute lung injury by down-regulating TLR4/NF-κB signaling cascade and inhibiting NLRP3 inflammasome activation

Preclinical Evaluation of Protective Effects of Terpenoids Against Nanomaterial‐Induced Toxicity: A Meta‐Analysis

EGR-1 Contributes to Pulmonary Edema by Regulating the Epithelial Sodium Channel in Lipopolysaccharide-Induced Acute Lung Injury

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