Efficacy of tetracyclines in the treatment of acne vulgaris: a review

Simonart, Thierry; Dramaix, M.; Maertelaer, Viviane De

doi:10.1111/j.1365-2133.2007.08286.x

Cited by 46 publications

(52 citation statements)

References 73 publications

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“…Common side effects of tetracyclines are photosensitivity, gastrointestinal complaints, and irreversible dental staining in children [36,38]. Tetracyclines should not be taken together with iron supplements, antacids, or milk, because together they can form insoluble complexes in the intestine, and reduce their absorption.…”

Section: Tetracyclinesmentioning

confidence: 99%

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Deckers

Prens

2015

Drugs

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent inflammatory nodules mostly located in the armpits and groin. Over the years multiple treatments for HS have been proposed; however, to date a cure is still lacking. In this update we provide an overview of most drug treatments reported on for HS, where possible with their mode of action and side effects. In mild cases, clindamycin lotion or resorcinol cream have proven effective. Tetracyclines are a first-line systemic option in more widespread or severe cases, followed by the combination of clindamycin and rifampicin. However, the recurrence rate is high after discontinuation of clindamycin plus rifampicin combination therapy. Long-term treatment with retinoids, especially acitretin is feasible, although teratogenicity has to be taken into account in females of reproductive age. Multiple antiinflammatory drugs have been suggested for HS, such as dapsone, fumarates or cyclosporine. However, their effectiveness in HS is based on small case series with varying results. If most common treatments have failed, biologics (e.g., infliximab or adalimumab) are the next step. Although not addressed in this review, surgical interventions are often needed to achieve remission. Key PointsHidradenitis suppurativa (HS) is a chronic inflammatory skin disease without a cure.Antibiotics (topical or oral) are often the first treatment option for HS.In cases of more extensive or therapy-resistant HS, biologicals (e.g., infliximab or adalimumab) are a good therapeutic option.

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Section: Tetracyclinesmentioning

confidence: 99%

An Update on Medical Treatment Options for Hidradenitis Suppurativa

Deckers

Prens

2015

Drugs

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“…Apart from benzoyl peroxide, the use of topical antibacterials such as erythromycin and clindamycin in monotherapy resulted in the development of antibiotic-resistant strains of not only C. acnes but also of S. epidermidis in 4–6 weeks [30, 57, 66]. Systemic antibiotics have been reported to cause only little resistance but can lead to collateral damage in gut microbiota [30, 33, 67]. Oral isotretinoin normalises the response of the innate immune system to C. acnes by inhibiting its proliferation [68].…”

Section: Resultsmentioning

confidence: 99%

<b><i>Staphylococcus epidermidis</i></b>: A Potential New Player in the Physiopathology of Acne?

Claudel¹,

Auffret²,

Leccia

et al. 2019

Dermatology

121

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Background: Cutibacterium acnes has been identified as one of the main triggers of acne. However, increasing knowledge of the human skin microbiome raises questions about the role of other skin commensals, such as Staphylococcus epidermidis, in the physiopathology of this skin disease. Summary: This review provides an overview of current knowledge of the potential role of S. epidermidis in the physiopathology of acne. Recent research indicates that acne might be the result of an unbalanced equilibrium between C. acnes and S. epidermidis,according to dedicated interactions. Current treatments act on C. acnesonly. Other treatment options may be considered, such as probiotics derived from S. epidermidis to restore the naturally balanced microbiota or through targeting the regulation of the host’s AMP mediators. Key Messages: Research seems to confirm the beneficial role of S. epidermidis in acne by limiting C. acnes over-colonisation and inflammation.

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“…77 A systematic review evaluating data from available trials to compare the efficacy of various tetracyclines in the treatment of acne concluded there was insufficient evidence to support one tetracycline relative to another. 78 Tetracyclines are approved by the FDA for short-term treatment of acne in addition to adjunctive therapy.…”

Section: Mechanism Of Action and Adverse Effectsmentioning

confidence: 99%

Non–anti-infective Effects of Antimicrobials and Their Clinical Applications

Sadarangani

Estes

Steckelberg

2015

Mayo Clinic Proceedings

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Antimicrobial agents are undoubtedly one of the key advances in the history of modern medicine and infectious diseases, improving the clinical outcomes of infection owing to their inhibitory effects on microbial growth. However, many antimicrobial agents also have biological activities stemming from their interactions with host receptors and effects on host inflammatory responses and other human or bacterial cellular biological pathways. These result in clinical uses of antimicrobial drugs that are distinct from their direct bacteriostatic or bactericidal properties. We reviewed the published literature regarding non-anti-infective therapeutic properties and proposed clinical applications of selected antimicrobials, specifically, macrolides, tetracyclines, sulfonamides, and ketoconazole. The clinical applications reviewed were varied, and we focused on uses that were clinically relevant (in terms of importance and burden of disease) and where published evidence exists. Such uses include chronic inflammatory pulmonary and skin disorders, chronic periodontitis, gastrointestinal dysmotility, rheumatoid arthritis, and cancer. Most of these potential therapeutic uses are not Food and Drug Administration approved. Clinicians need to weigh the use of antimicrobial agents for their non-anti-infective benefits, considering potential adverse effects and long-term effect on microbial resistance.

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Efficacy of tetracyclines in the treatment of acne vulgaris: a review

Cited by 46 publications

References 73 publications

An Update on Medical Treatment Options for Hidradenitis Suppurativa

An Update on Medical Treatment Options for Hidradenitis Suppurativa

<b><i>Staphylococcus epidermidis</i></b>: A Potential New Player in the Physiopathology of Acne?

Non–anti-infective Effects of Antimicrobials and Their Clinical Applications

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