Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep

Sager, Heinz; Hosking, B. C.; Bapst, B.; Stein, P.A.; Vanhoff, K.; Kaminsky, Ronald

doi:10.1016/j.vetpar.2008.10.006

Cited by 43 publications

(34 citation statements)

References 17 publications

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“…The controlled efficacy studies used both experimentally and naturally infected sheep that were treated when nematode burdens were at either the adult or fourth larval stage, and the experimental designs of the new studies (including numbers of animals) were comparable to those described in Hosking et al 2008Hosking et al , 2009aBustamante et al 2009;Kaminsky et al 2009 andSager et al 2009. Thus, pooling of data for this present analysis was valid (Vercruysse et al 2001).…”

Section: Methodsmentioning

confidence: 99%

“…The efficacy of monepantel has recently been disclosed in a series of publications reviewing dose determination (Hosking et al 2008;Kaminsky et al 2009), dose confirmation (Bustamante et al 2009;Hosking et al 2009a;Sager et al 2009) and field efficacy studies (Hosking et al 2009b;Mason et al 2009). However, these publications only reported the results of individual studies (dose determination and confirmation) or individual farm sites within studies (field efficacy).…”

Section: Introductionmentioning

confidence: 99%

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A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep

et al. 2009

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Monepantel is the first compound from the amino-acetonitrile derivative class of anthelmintics to be developed for the control of gastrointestinal nematodes of sheep. An analysis of pooled data from a series of controlled studies is reported providing a single point of efficacy (+/- 95% confidence interval) for each gastrointestinal nematode tested at the fourth larval and/or adult stages. For most nematode species, the pooled efficacy was greater than 99%, and for the remaining few species, efficacy was greater than 90%. These data are well supported by field studies conducted across five countries, where the pooled efficacy (on the basis of fecal worm egg count reduction) was in most cases, greater than 99% (depending on the calculation used). Monepantel is highly effective when administered to sheep at 2.5 mg/kg, and its introduction as a new anthelmintic for sheep is timely, given the problems with anthelmintic resistance that the world's sheep farmers are now experiencing.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep

et al. 2009

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“…Its efficacy from numerous controlled studies conducted in Australia, New Zealand, and Switzerland has been previously reported (Hosking et al 2008Kaminsky et al 2009;Sager et al 2009). This manuscript reports the results of five studies conducted in Argentina, Brazil, and Uruguay and includes efficacy data against several nematode species not previously tested.…”

Section: Introductionmentioning

confidence: 94%

The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America

Bustamante¹,

Steffan

Morlán³

et al. 2009

Parasitol Res

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The efficacy of the novel anthelmintic, monepantel (an amino-acetonitrile derivative), was investigated in sheep naturally infected with gastrointestinal nematodes in five studies in Argentina, Brazil, and Uruguay. Monepantel, administered at 2.5 mg/kg liveweight, was highly effective (>99.7%) against Haemonchus contortus, Teladorsagia (Ostertagia) circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia curticei, Cooperia mcmasteri, Cooperia oncophora, Cooperia pectinata, Cooperia punctata, and Nematodirus spathiger, including strains resistant to the older broad-spectrum anthelmintics. Efficacy against C. mcmasteri, C. pectinata, and C. punctata is documented for the first time. The treatment with monepantel was well tolerated by the sheep.

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“…But, due to their free, indiscriminate and inappropriate use, the parasite is developing resistance against currently used anthelmintics (Alvarez- Sanchez et al 2006, Easwaran et al 2009, Domke et al 2012. A new synthetic drug, monopantel of amino-acetonitrile derivative group has been developed with promising claim in experimental trials, but, marketing and practice as anthelmintic is in infancy stage (Sager et al 2009). Therefore, it is important to establish a successful programme and to look for the search of alternative, newer, inexpensive, safe and environmental friendly antinematodal agent that may act for longer period, before resistance set in.…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic efficacy of aqueous extract of Zanthoxylum armatum DC. seeds against Haemonchus contortus of small ruminants

Singh¹,

Singh²,

Verma³

et al. 2014

J Parasit Dis

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Haemonchus contortus infection is the major hurdle in growth and productivity in small ruminants especially in tropical countries. Indiscriminate and long term use of currently available chemotherapeutic agents lead to development of resistance in microorganisms and residual problems in population. Therefore, present study was undertaken to evaluate the anthelmintic efficacy of aqueous extract of Zanthoxylum armatum DC. seeds against adult H. contortus worms of small ruminants. Proximate analysis of seed powder shows high crude protein, Cu, Zn and Ca concentration. Phytochemical ingredients of extract revealed high total phenolic, flavonoids and tannin contents. In vitro experimental trial revealed complete mortality of H. contortus worms at the concentration of 100 mg/ml at the time exposure of 8 h. At 50 mg/ml concentration the mortality at 6 and 8 h were 45.45 ± 4.55 and 63.64 ± 4.54 %. Median lethal concentration (LC 50 ) at 6 and 8 h were 59.90 and 28.92 mg/ ml, respectively. Levamisole at concentration of 0.5 mg/ml caused 50 % mortality at 2 h post exposure and 100 % mortality at 4 h post exposure. The results confirm the cidal effect of the aqueous extract of Z. armatum DC. seeds on adult H. contortus worms.

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Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep

Cited by 43 publications

References 17 publications

A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep

A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep

The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America

Anthelmintic efficacy of aqueous extract of Zanthoxylum armatum DC. seeds against Haemonchus contortus of small ruminants

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