Efficacy of the Influenza Vaccine in Patients with Malignant Lymphoma

Immunogenicity of a monovalent influenza A(H1N1)pdm09 vaccine in patients with hematological malignancies

“…Recent studies have also shown the low immunogenicity of influenza vaccines in lymphoma patients and patients on rituximab treatment. [30][31][32][33][34][35][36][37][38][39][40][41][42][43] The results obtained by us here are in agreement with those findings. Subjects having pre-titer ≥ 1:10 did not show any increase in antibody response after the second vaccination.…”

“…[23][24][25][26][27][28][29] There have been quite a few reports about the low immunogenicity of influenza vaccines in patients with hematological malignancies. [30][31][32][33][34][35][36][37][38] The results obtained by use here agree with their findings. In healthy adults usually the induction of antibody reaches a plateau after one vaccination.…”

“…However there have been only a limited number of reports and they showed conflicting data. [9][10][11][12][13][14][15][16] In March 2009, a novel influenza A(H1N1) virus was reported in North America. [17][18][19] This virus spread globally and brought about the 2009 influenza pandemic.…”

Safety and Immunogenicity of Two Influenza Virus Subunit Vaccines, with or without MF59 Adjuvant, Administered to Human Immunodeficiency Virus Type 1-Seropositive and -Seronegative Adults

“…Few studies, to our knowledge, have been reported on the effects of vaccines with MF59 adjuvant administered to adults and to HIV-1-seropositive patients (9), for whom there is a great need to improve the immune response to vaccination (17,28,37,52).…”

Immunogenicity of an Inactivated Monovalent 2009 Influenza A (H1N1) Vaccine in Patients Who Have Cancer

“…Most have reported low response rates in cancer patients, particularly muted humoral response in patients who have lymphoproliferative disorders [10 -14]. Some have reported that the response is delayed [11]. In addition, there is inadequate evidence concerning the best time to vaccinate patients who are actively receiving chemotherapy.…”