Efficacy of the Injectable Calcium Phosphate Ceramics Suspensions Containing Magnesium, Zinc and Fluoride on the Bone Mineral Deficiency in Ovariectomized Rats

Otsuka, Makoto; Oshinbe, Ayako; LeGeros, Racquel Z.; Tokudome, Yoshihiro; Ito, Atsuo; Otsuka, Kuniko; Higuchi, William I.

doi:10.1002/jps.21131

Cited by 55 publications

(44 citation statements)

References 28 publications

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“…These two essential elements are involved in the defense against oxidative stress, DNA repair, methylation reactions, cell proliferation, and apoptosis [15]. Zinc with a prominent role as a functional cofactor of more than 200 enzymes is involved in a number of cellular activities including cell proliferation and DNA integrity [44]. Zinc might also have anticarcinogenic properties due to its role in metallothionein production, which inhibits free radicals [3].…”

Section: Resultsmentioning

confidence: 99%

Serum Copper and Zinc Levels Among Iranian Colorectal Cancer Patients

Khoshdel

Naghibalhossaini

Abdollahi

et al. 2015

Biol Trace Elem Res

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Alterations of trace element concentrations adversely affect biological processes and could promote carcinogenesis. Only a few studies have investigated the degree of changes in copper and zinc levels in colorectal cancer (CRC). The aim of the present study was to compare the serum copper (Cu) and zinc (Zn) concentrations in patients with CRC from Iran with those of healthy subjects. Cu and Zn concentrations in the serum of 119 cancer patients and 128 healthy individuals were measured by atomic absorption spectrometry. We found a significant decrease in the total mean serum Cu and Zn concentrations in CRC patients as compared with the control group (137.5 ± 122.38 vs. 160.68 ± 45.12 μg/dl and 81.04 ± 52.05 vs. 141.64 ± 51.75, respectively). However, the serum Cu/Zn ratio in the patient group was significantly higher than that measured in the control group (p = 0.00). There was no significant difference in the mean values of serum Cu and Zn concentrations between young (<60 years) and elderly (≥60 years) patients. However, the Cu/Zn ratio in <60-year cases was significantly higher than that in ≥60-year age group (p < 0.05). In addition, mean serum Cu level in normal weight patients was significantly higher than that in overweight/obese cases (132.31 ± 87.43 vs. 103.81 ± 53.72 μg/dl, respectively) (p < 0.05). There was no difference in mean serum Cu and Zn concentrations in patients stratified by the site, stage, or differentiation grade of tumors. Our findings suggest that imbalance in Cu and Zn trace element level is associated with CRC and might play an important role in cancer development among Iranian patients.

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Section: Resultsmentioning

confidence: 99%

Serum Copper and Zinc Levels Among Iranian Colorectal Cancer Patients

Khoshdel

Naghibalhossaini

Abdollahi

et al. 2015

Biol Trace Elem Res

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“…The continuous dissolution associated with the MCPB produced a Ca-and Mg-rich environment that might be responsible for stimulating cell proliferation and differentiation. The biocompatibility and bioactivity of biomaterials is very closely related to the cell behaviour in contact with them and particularly to the cell spread on their surface (Otsuka et al 2008). SEM results showed that the cells spread well and formed a confluent layer with very close attachment to the sample surface, while maintaining physical contact with each other.…”

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confidence: 99%

Development of magnesium calcium phosphate biocement for bone regeneration

Jia

Zhou

Wei

et al. 2010

J. R. Soc. Interface.

101

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Magnesium calcium phosphate biocement (MCPB) with rapid-setting characteristics was fabricated by using the mixed powders of magnesium oxide (MgO) and calcium dihydrogen phosphate (Ca(H 2 PO 4 ) 2 . H 2 O). The results revealed that the MCPB hardened after mixing the powders with water for about 7 min, and the compressive strength reached 43 MPa after setting for 1 h, indicating that the MCPB had a short setting time and high initial mechanical strength. After the acid -base reaction of MCPB containing MgO and Ca(H 2 PO 4 ) 2 . H 2 O in a molar ratio of 2 : 1, the final hydrated products were Mg 3 (PO 4 ) 2 and Ca 3 (PO 4 ) 2 . The MCPB was degradable in Tris-HCl solution and the degradation ratio was obviously higher than calcium phosphate biocement (CPB) because of its fast dissolution. The attachment and proliferation of the MG 63 cells on the MCPB were significantly enhanced in comparison with CPB, and the alkaline phosphatase activity of MG 63 cells on the MCPB was significantly higher than on the CPB at 7 and 14 days. The MG 63 cells with normal phenotype spread well on the MCPB surfaces, and were attached in close proximity to the substrate, as seen by scanning electron microscopy (SEM). The results demonstrated that the MCPB had a good ability to support cell attachment, proliferation and differentiation, and exhibited good cytocompatibility.

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“…Thus, magnesium containing calcium phosphates is more appropriate for biomaterials and their applications [62]. Magnesium ions play important roles in the formation and transformation of biologically related calcium phosphates [65,66]. MgF 2 ion is known as the most promising dental caries-promoting element due to a high initial calcification process in the bone formation [37,38].…”

Section: Discussionmentioning

confidence: 99%

Sintering of the Tricalcium Phosphate-Titania-Magnesium Fluoride Composites

Ayadi¹,

Ayed²

2018

Sintering of Functional Materials

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Titania (TiO 2 ) and magnesium fluoride (MgF 2 ) can be mixed with tricalcium phosphate (β-Ca 3 (PO 4 ) 2 , β-TCP) to make bioceramic composites, which would combine the biocompatibility of the β-TCP and the high tribological properties of TiO 2 and MgF 2 for biomedical applications. The samples were characterized by different characterization techniques such as physicochemical and mechanical. The sintering of the TCP at various temperatures (1000, 1100, 1200 and 1300°C) with different percentages of titania (2.5, 5, 7.5, 10, 20, 30, 40 and 50 wt%) was studied. The performances of the TCP-TiO 2 composites increase with both the sintering temperature and the amount of titania. The highest values of the composites' (H = 270 Hv; E = 33.1 GPa and G = 15.7 GPa) were obtained with 40 wt% titania at 1200°C. Moreover, the addition of 4 wt% MgF 2 to the TCP-40 wt% TiO 2 composites leads to better mechanical properties (σ r = 27 MPa; H = 360 Hv; E = 51 GPa and G = 20 GPa) at 1200°C for 1 h. The amelioration of these properties is due to the formation of a new compound and the liquid phase which helps to fill the pores in the microstructure. The obtained performances of the TCP-TiO 2 -MgF 2 composites are similar to those of bone tissue and especially as enamel.

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Efficacy of the Injectable Calcium Phosphate Ceramics Suspensions Containing Magnesium, Zinc and Fluoride on the Bone Mineral Deficiency in Ovariectomized Rats

Cited by 55 publications

References 28 publications

Serum Copper and Zinc Levels Among Iranian Colorectal Cancer Patients

Serum Copper and Zinc Levels Among Iranian Colorectal Cancer Patients

Development of magnesium calcium phosphate biocement for bone regeneration

Sintering of the Tricalcium Phosphate-Titania-Magnesium Fluoride Composites

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