Efficacy of the morantel sustained release trilaminate matrix against gastrointestinal nematodes in beef calves

Rickard, Lora G.; Zimmerman, Gary L.; Hoberg, Eric P.; Lockwood, P.W.; Weber, D. W.; Miller, Roger D.

doi:10.1016/0304-4017(89)90060-5

Cited by 10 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in the output of eggs per animal throughout the year were measured using the method of Rickard et al . [15]…”

Section: Methodsmentioning

confidence: 99%

New oral anthelmintic intraruminal delivery device for cattle

Vandamme

2014

J Pharm Bioall Sci

View full text Add to dashboard Cite

Background:The purpose of this work was to develop a new oral drug delivery system intended for cattle and that enables delayed and pulsed release of an anthelmintic agent.Materials:This new tailored dosage form, also called reticulo-rumen device (RRD) has been evaluated on grazing calves by means of measurements of milliunits of tyrosine concentration, number of eggs per gram of feces, mean number of infective larvae on cattle pasture and increase in mean weight of cattle.Methods:The in vivo evaluation was carried out during two grazing seasons on different groups of dairy cattle. During the first grazing season, Group 1 was designated as an untreated control group. The remaining two were assigned to different treatments as follows: Group 2, early season suppression with a marketed intraruminal slow release bolus (Chronomintic®, Virbac) administered immediately prior to turn-out and Group 3, mid-season suppression with a new RRD administered immediately prior to turn out. When the cattle were turned out at the start of the second grazing season, they were not given any anthelmintic treatment and were divided into two different groups, corresponding to the previous groups that received an anthelmintic treatment during the first grazing season, on that pasture that they had occupied as separate groups in the previous year. Furthermore, during the second season, samples of feces, blood and herbage were collected every month.Results and Conclusion:During the first grazing season, the results indicated that the fecal egg counts and the number of infective larvae in herbage samples were slightly lower for the group receiving the new RRDs. Regular weighing of the cattle receiving the new RRDs revealed no significant difference with cattle receiving marketed RRDs. Conversely, during the second grazing season, the results for the mean weights of the cattle demonstrated that the weights of animals having been administered new RRDs during the first grazing season were significantly different (P < 0.05) from those in the second group treated with a Chronomintic® during the first grazing season. A difference in mean weight of 26 kg was observed between these two groups.

show abstract

“…Changes in the output of eggs per animal throughout the year were measured using the method of Rickard et al . [15]…”

Section: Methodsmentioning

confidence: 99%

New oral anthelmintic intraruminal delivery device for cattle

Vandamme

2014

J Pharm Bioall Sci

View full text Add to dashboard Cite

show abstract

Macrogol

Bruchhausen

Ebel

Hackenthal

et al. 1993

Hagers Handbuch Der Pharmazeutischen Praxis

View full text Add to dashboard Cite

Efficacy of morantel sustained release trilaminate bolus against gastrointestinal nematodes in grazing dairy calves in Kenya

Waruiru¹,

Weda²,

Bøgh³

et al. 1997

Trop Anim Health Prod

View full text Add to dashboard Cite

The efficacy of morantel sustained release trilaminate (MSRT) bolus against gastrointestinal nematodes was evaluated under field conditions over a 10-month period. Twenty weaner calves were randomly divided into 2 groups of 10 calves each and grazed from March to December on adjacent, similarly contaminated paddocks. Group 1 calves (T-1) served as untreated controls while group 2 calves (T-2) were dosed at turnout with MSRT bolus designed to release morantel tartrate continuously for 90 days. The efficacy of MSRT was assessed by comparison of parasitological data (faecal worm egg counts, herbage larval counts, worm counts from tracer calves and set-stocked trial calves, determination of haematological parameters and pepsinogen levels), weight gains and clinical status of the animals. Faecal egg counts from the treated group (T-2) were reduced by 100% (P < 0.001) following treatment and remained significantly (P < 0.05) lower than counts from T-1 calves up to trial termination. The use of MSRT bolus resulted in a reduction of 92% (P < 0.001) in the number of gastrointestinal nematodes in set-stocked calves at the end of the study and a 55 to 85.7% reduction in herbage larval infectivity as reflected in lowered parasite burdens in tracer calves. At the trial termination, the control calves had gained on average (+/- s.d.) 59.4 +/- 4.8 kg (200.0 +/- 7.4 g day-1) and the treated ones on an average 128.6 +/- 10.5 kg (530.0 +/- 13.1 g day-1).

show abstract

Efficacy of the morantel sustained release trilaminate matrix against gastrointestinal nematodes in beef calves

Cited by 10 publications

References 7 publications

New oral anthelmintic intraruminal delivery device for cattle

New oral anthelmintic intraruminal delivery device for cattle

Macrogol

Efficacy of morantel sustained release trilaminate bolus against gastrointestinal nematodes in grazing dairy calves in Kenya

Contact Info

Product

Resources

About