Efficacy of thermoplastic polyurethane and gelatin blended nanofibers covered stent graft in the porcine iliac artery

Ryu, Dae Sung; Won, Dong-Sung; Kim, Ji Won; Park, Yubeen; Kim, Song Hee; Kang, Jeon Min; Zeng, Chu Hui; Lim, Dohyung; Choi, Hyun Chul; Park, Jung Hoon

doi:10.1038/s41598-022-20950-w

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…The scaffolds produced from such blends possessed novel properties such as increased stiffness, and hemo- or biocompatibility [ 21 , 22 ]. Mixtures of PU and gelatin have higher bio- and hemocompatibility, as previously demonstrated [ 23 , 24 , 25 ] and confirmed in an independent study by our Korean colleagues [ 26 ]. Thus, materials obtained from PU-gelatin blends are promising scaffolds for tissue engineering.…”

Section: Introductionsupporting

confidence: 82%

“…Previously, we have shown that the scaffolds of this composition demonstrate advantages over other blends of PU with gelatin (5, 10, and 20%) in terms of their biocompatibility and mechanical properties in experiments in vitro [ 24 ]. Data from the independent study showed that scaffolds obtained from a blend containing 3% Tecoflex EG-80A and 15% gelatin could be recommended as a promising material for the production of cardiovascular devices [ 25 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Effect of Sterilization Methods on Electrospun Scaffolds Produced from Blend of Polyurethane with Gelatin

Chernonosova

Kuzmin

Shundrina

et al. 2023

JFB

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Fibrous polyurethane-based scaffolds have proven to be promising materials for the tissue engineering of implanted medical devices. Sterilization of such materials and medical devices is an absolutely essential step toward their medical application. In the presented work, we studied the effects of two sterilization methods (ethylene oxide treatment and electron beam irradiation) on the fibrous scaffolds produced from a polyurethane-gelatin blend. Scaffold structure and properties were studied by scanning electron microscopy (SEM), atomic force microscopy (AFM), infrared spectroscopy (FTIR), a stress-loading test, and a cell viability test with human fibroblasts. Treatment of fibrous polyurethane-based materials with ethylene oxide caused significant changes in their structure (formation of glued-like structures, increase in fiber diameter, and decrease in pore size) and mechanical properties (20% growth of the tensile strength, 30% decline of the maximal elongation). All sterilization procedures did not induce any cytotoxic effects or impede the biocompatibility of scaffolds. The obtained data determined electron beam irradiation to be a recommended sterilization method for electrospun medical devices made from polyurethane-gelatin blends.

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Section: Introductionsupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Effect of Sterilization Methods on Electrospun Scaffolds Produced from Blend of Polyurethane with Gelatin

Chernonosova

Kuzmin

Shundrina

et al. 2023

JFB

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“…Herein, we developed the closed-cell SEMS using the hand-knitted technique and expanded-polytetrafluoroethylene (e-PTFE) as a covering membrane to evaluate patency, thrombosis, and degree of neointimal hyperplasia formation. The stent materials adopted in this study, nitinol, and e-PTFE, have been used extensively in stent-grafts showing good biocompatibility for the treatment of various vascular diseases 14 . Hence, the purpose of this study was to investigate the efficacy of closed-cell SEMS with or without an e-PTFE membrane in a porcine iliac artery model.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of closed cell self expandable metallic stent for peripheral arterial disease in the porcine iliac artery

Ryu

Won

Kim

et al. 2023

Sci Rep

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This study aimed to investigate the efficacy of a closed-cell self-expandable metallic stent (SEMS) with or without expanded-polytetrafluoroethylene (e-PTFE)-covering membrane in a porcine iliac artery model. Twelve Yorkshire domestic pigs were divided into a bare closed-cell SEMS (B-SEMS) group (n = 6) and covered closed-cell SEMS (C-SEMS) group (n = 6). Both closed-cell SEMSs were placed in the right or left iliac artery. Thrombogenicity score in the C-SEMS group was significantly higher than that in the B-SEMS group (p = 0.004) after 4 weeks. Angiographic findings of mean luminal diameters at 4 weeks follow-up did not differ significantly between B-SEMS and C-SEMS groups. Neointimal hyperplasia thickness as well as degree of inflammatory cell infiltration and collagen deposition in the C-SEMS group was significantly greater than that in the B-SEMS group (p < 0.001). Closed-cell SEMSs successfully maintained patency for 4 weeks without stent-related complications in the porcine iliac artery. Although mild thrombus with neointimal hyperplasia was observed in the C-SEMS group, subsequent occlusion, and in-stent stenosis did not occur in any of the pigs until the end of the study. Closed-cell SEMS with or without the e-PTFE covering membrane is effective and safe for the porcine iliac artery.

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Enhancing 3D printing sustainability: Reinforcing thermoplastic polyurethane with recycled polyurethane foam for durable applications in orthopedic footwear

Mohamed,

Nassef,

Morsy

et al. 2024

Vinyl Additive Technology

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This study seeks to advance the realm of 3D printing through the exploration of fabricating polymer matrix composite objects using recycled materials, with a particular emphasis on bolstering durability. Characterization was carried out by integrating polyurethane foam (PUF) residues into thermoplastic polyurethane (TPU) composites at different concentrations (ranging from 3% to 10% wt/wt), which are frequently employed in 3D printing. The chemical functions were analyzed using Fourier‐transform infrared spectroscopy (FTIR), while thermal stability was measured through thermal gravimetric analysis (TGA). The morphology characterized of the material via scanning electron microscopy (SEM) and density measurement identified that the surface roughness and void content of the PUF/TPU composite materials was a significant factor affecting the measured mechanical properties. Experimental results indicate that higher PUF content enhances filament properties and the resultant 3D printed products, showcasing a reduction in both the density and melt index of the produced filament by 15.9% and 34.4%, respectively, with the addition of 5% wt./wt. PUF residues to TPU. Additionally, there was a notable increase in Young's modulus of the produced filament by 79.9% and maximum stress by 12.7%, while elongation at break was reduced by 24.9%. Furthermore, the study highlights the sustainability advantages of utilizing recycled PUF, contributing to waste reduction and associated cost savings. Recycled PUF emerges as a cost‐effective additive for synthesizing 3D polymeric materials, holding promise for diverse applications such as orthopedic footwear, leveraging the desirable attributes of TPU.Highlights Recycled (PUF)/TPU composites for 3D printing, enhancing durability. PUF content improves filament properties, reducing density and melt index. Young's modulus and maximum stress of produced filament increases. Utilizing recycled PUF reduces waste and promises sustainability.

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Efficacy of thermoplastic polyurethane and gelatin blended nanofibers covered stent graft in the porcine iliac artery

Cited by 6 publications

References 32 publications

Effect of Sterilization Methods on Electrospun Scaffolds Produced from Blend of Polyurethane with Gelatin

Effect of Sterilization Methods on Electrospun Scaffolds Produced from Blend of Polyurethane with Gelatin

Efficacy of closed cell self expandable metallic stent for peripheral arterial disease in the porcine iliac artery

Enhancing 3D printing sustainability: Reinforcing thermoplastic polyurethane with recycled polyurethane foam for durable applications in orthopedic footwear

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