Efficacy of Tocilizumab in the Treatment of Systemic Onset Juvenile Idiopathic Arthritis

Efficacy and safety of tofacitinib in the treatment of refractory cases of polyarticular course juvenile idiopathic arthritis: A study from Bangladesh

“…Decrease in ESR after initiation of tofacitinib was significant ( P < .001) which was similar to the study done by Islam et al on use of tocilizumab in refractory sJIA where ESR decreased significantly after initiation of therapy 25 …”

“…Steroid tapering effect of tofacitinib was significant and ultimately steroid was withdrawn among cases. This effect is comparable with the study by Islam et al on the use of tocilizumab in refractory sJIA where steroid tapering effect was also significant 25 . Reduction of dose and eventually withdrawal as soon as possible may prevent the development of severe and irreversible complications of steroids.…”

“…19,20,24 Decrease in ESR after initiation of tofacitinib was significant (P < .001) which was similar to the study done by Islam et al on use of tocilizumab in refractory sJIA where ESR decreased significantly after initiation of therapy. 25 Analysis of the disease activity in this study was done by JADAS 27. The JADAS was found to be a valid instrument for assessment of disease activity in JIA and is potentially applicable in standard clinical care, observational studies, and clinical trials.…”