Efficacy of tocilizumab treatment in cerulein-induced experimental acute pancreatitis model in rats

Hancerlı, Yusuf; Kaplan, Mustafa; Tanoğlu, Alpaslan; Yeşilbaş, Soner; Küçükodacı, Zafer; Yıldırım, Muhammet; Narlı, Gizem; Sakin, Yusuf Serdar

doi:10.5152/tjg.2017.16738

Cited by 15 publications

(14 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12 Zielecki ve ark. 45 46,47 . ABD Gıda ve İlaç Birliği (FDA) onaylı faz III, tocilizumab üzerinde randomize kontrollü çalışmalar devam etmektedir 48 .…”

Section: Covid-19 Pankreas Tutulumu: Olası Mekanizma Ve Tanıunclassified

COVID-19-Akut Pankreatit İlişkisinin İncelenmesi

Demiray¹,

Yılmaz

ALIRAVCI

et al. 2021

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

View full text Add to dashboard Cite

pandemisi şu an için dünya çapında iki milyondan fazla insanın ölümüne neden olmuştur. Hastalığın ciddiyeti subklinik infeksiyonlardan hastaneye yatmayı gerektiren ağır hastalığa kadar değişmektedir. COVID-19 hastalık etkeni olan SARS-CoV-2 esas olarak solunum yolunu etkiler, ancak mide bulantısı, kusma ve ishal gibi gastrointestinal semptomlar da ortaya çıkabilmektedir. Karın ağrısı, COVID-19 hastalığı ile ilişkili bilinen semptomlardan biridir. Şiddetli COVID-19 infeksiyonunun bir komplikasyonu olarak akut pankreatit gelişimi hakkında çok az veri bulunmaktadır. COVID-19 hastalarının bazılarında pankreas enzim yüksekliği ve nadir de olsa akut pankreatit gelişebilmektedir. Bu durum özellikle ciddi klinik tablo ile ilişkilidir. COVID-19'da pankreas tutulum mekanizması net anlaşılamamıştır. Bu derlemede COVID-19 ilişkili pankreatitin değerlendirilmesi amaçlanmıştır.

show abstract

“…12 Zielecki ve ark. 45 46,47 . ABD Gıda ve İlaç Birliği (FDA) onaylı faz III, tocilizumab üzerinde randomize kontrollü çalışmalar devam etmektedir 48 .…”

Section: Covid-19 Pankreas Tutulumu: Olası Mekanizma Ve Tanıunclassified

COVID-19-Akut Pankreatit İlişkisinin İncelenmesi

Demiray¹,

Yılmaz

ALIRAVCI

et al. 2021

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

View full text Add to dashboard Cite

show abstract

“…Acute pancreatitis is an inflammatory event of the pancreas which may affect seriously all other tissues and organ systems (1)(2)(3). Generally, acute pancreatitis is induced by alcoholism or gallstones.…”

Section: Dear Editormentioning

confidence: 99%

Tigecycline induced acute pancreatitis: Suspicion is the first step in diagnosis

Tanoğlu

Çağıltay

2021

Anatolian Current Medical Journal

View full text Add to dashboard Cite

show abstract

“…Patients with AP have a pancreas with varying degrees of fibrosis, acinar cell regeneration, and formation of tubular complexes [5][6][7][8][9]. Past studies have shown that fibroblast growth factor-1 (FGF1), fibroblast growth factor-2 (FGF2), hepatocyte growth factor, transforming growth factor-a [9], insulin-like growth factor-1 [10,11], transforming growth factor-b (TGF-b), and epidermal growth factor levels in the edematous AP rat model were higher in AP rats compared with healthy controls [12][13][14]. Therefore, these factors are necessary for angiogenesis, mitogenesis, chemotaxis, progression, and sustainability of the enhanced malignant growth [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Fibroblast Growth Factor (FGF) Signaling Protects Against Acute Pancreatitis-Induced Damage by Modulating Inflammatory Responses

Zhao

Chen

et al. 2020

Med Sci Monit

View full text Add to dashboard Cite

Science and Technology Plan Projects of Putian City (2018s3001) Background:Acute pancreatitis (AP) is a symptom of sudden pancreas inflammation, which causes patients severe suffering.In general, fibroblast growth factor (FGF) levels are increased and amylase and lipase activities are elevated during AP pathogenesis, but protein concentration are low. However, the mechanism through which FGF signaling regulates AP pathogenesis remains elusive. Material/Methods:The concentrations of PGE2, TNF-a, sCRP, FGF1, and FGF2 in the serum samples of the AP group and healthy control group were detected by enzyme-linked immunosorbent assay. In addition, IkBa and p-IkBa levels were analyzed in the serum samples. Subsequently, the AP rat model was established, and FGF1, FGF2, anti-FGF1, and anti-FGF2 antibodies and Bay11-7082 were injected into AP rats. TNF-a, PAI-1 JNK, p-JNK, IkBa, and p-IkBa levels were also examined. Results:Results showed that levels of PGE2, TNF-a, sCRP, p-IkBa, FGF1, and FGF2, as well as amylase and lipase activity were increased in patients with AP compared with those in healthy people. In addition, protein concentrations were lower in patients with AP than in the healthy group. Activation of FGF signaling by injecting FGF1 or FGF2 also inhibited AP-induced inflammation response in the pancreas and increased amylase and lipase activities, as well as protein concentration. However, the injection of FGF1 and FGF2 antibodies accelerated APmediated inflammation responses in the serum. In addition, Bay11-7082 injection inhibited AP activation of inflammation response and amylase and lipase activities. Protein concentration were also increased in AP rats. Conclusions:FGF signaling protects against AP-mediated damage by inhibition of AP-activating inflammatory responses.

show abstract

Efficacy of tocilizumab treatment in cerulein-induced experimental acute pancreatitis model in rats

Cited by 15 publications

References 20 publications

COVID-19-Akut Pankreatit İlişkisinin İncelenmesi

COVID-19-Akut Pankreatit İlişkisinin İncelenmesi

Tigecycline induced acute pancreatitis: Suspicion is the first step in diagnosis

Fibroblast Growth Factor (FGF) Signaling Protects Against Acute Pancreatitis-Induced Damage by Modulating Inflammatory Responses

Contact Info

Product

Resources

About