Efficacy of Toki-shigyakuka-gosyuyu-syokyo-to (Danggui-Sini-Jia-Wuzhuyu-Shengjiang-Tang) on Peripheral Circulation in Autonomic Disorders

Kanai, Shigeyuki; Okano, Hideyuki; Abe, Hiroko

doi:10.1142/s0192415x9700010x

Cited by 23 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To avoid the influence of the haircoat, the tail temperature, which is used as an indicator of the peripheral circulation, was measured (14). The tail surface temperature was measured before and after 12 weeks of exposure to SMF in the OVX-M group, and at the respective time points in the OVX-D and normal groups.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of Static Magnetic Field for Locomotor Activity of Experimental Osteopenia

Taniguchi

Kanai²

2006

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

In order to examine the effectiveness of applying a static magnetic field (SMF) for increasing bone mineral density (BMD), we assessed the degree of osteopenia by dual-energy X-ray absorptiometry (DEXA), the metabolism measuring system, and histological examination of bone tissue in an ovariectomized (OVX) rat model. Thirty-six female Wistar rats (8 weeks old, 160–180 g) were divided into three groups. The rats in the OVX-M group were exposed to SMF for 12 weeks after ovariectomy. The ovariectomized rats in the OVX-D group were not exposed to SMF as a control. The rats in the normal group received neither ovariectomy nor exposure to SMF. Twelve-week exposure to SMF in the OVX-M group inhibited the reduction in BMD that was observed in the OVX-D group. Moreover, in the OVX rats, before exposure to SMF, there was no clear difference in the level of locomotor activity between the active and resting phases, and the pattern of locomotor activity was irregular. After exposure of OVX rats to SMF, the pattern of locomotor activity became diphasic with clear active and resting phases, as was observed in the normal group. In the OVX-M group, the continuity of the trabecular bone was maintained more favorably and bone mass was higher than the respective parameters in the OVX-D group. These results demonstrate that exposure to SMF increased the level of locomotor activity in OVX rats, thereby increasing BMD.

show abstract

Section: Methodsmentioning

confidence: 99%

Efficacy of Static Magnetic Field for Locomotor Activity of Experimental Osteopenia

Taniguchi

Kanai²

2006

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…One of the famous herbal prescriptions, Danggui-Sayuk-Ga-Osuyu-Saenggang-Tang (DSGOST; Danggui-Sini-Jia-Wuzhuyu-Shengjian-Tang in Chinese, Tokishigyakukagoshuyushokyoto in Japanese) has historically long been used for treating RP, since it has been thought to be useful for warming the interior on the basis of TCM theories [25–28, 30]. DSGOST is a mixed herbal medicine which consists of Angelica root, Cinnamon bark, Peony root, Akebia stem, Asarum root, Glycyrrhiza, Jujube, Evodia fruit, and Ginger [25–27, 30]. When rats were orally received with DSGOST, peripheral circulation in rat tails was improved [30].…”

Section: Introductionmentioning

confidence: 99%

Herbal Prescription, DSGOST, Prevents Cold‐Induced RhoA Activation and Endothelin‐1 Production in Endothelial Cells

Cho

Yeon

Park

et al. 2014

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Herbal prescription, Danggui-Sayuk-Ga-Osuyu-Saenggang-tang (DSGOST), has long been used to treat Raynaud's phenomenon (RP) in traditional Chinese medicine (TCM). However, a biological mechanism by which DSGOST ameliorates RP is yet deciphered. In this study, we demonstrate that DSGOST inhibits cold-induced activation of RhoA, in both vascular smooth muscle cells (VSMC) and endothelial cells (EC), and blocks endothelin-1-mediated paracrine path for cold response on vessels. While cold induced RhoA activity in both cell types, DSGOST pretreatment prevented cold-induced RhoA activation. DSGOST inhibition of cold-induced RhoA activation further blocked α2c-adrenoreceptor translocation to the plasma membrane in VSMC. In addition, DSGOST inhibited endothelin-1-mediated RhoA activation and α2c-adrenoreceptor translocation in VSMC. Meanwhile, DSGOST inhibited cold-induced or RhoA-dependent phosphorylation of FAK, SRC, and ERK. Consistently, DSGOST inhibited cold-induced endothelin-1 expression in EC. Therefore, DSGOST prevents cold-induced RhoA in EC and blocks endothelin-1-mediated paracrine path between EC and VSMC. In conclusion, our data suggest that DSGOST is beneficial for treating RP-like syndrome.

show abstract

“…Similar to Achyranthis Radix , Cinnamoni Cortex and Processi Aconiti Radix invigorate blood circulation. [2021] However, the prophylactic antiallodynic activity of HJG was weaker than that of GJG. Thus, although Cinnamoni Cortex and Processi Aconiti Radix may have some prophylactic antiallodynic activity, Plantaginis Semen and Achyranthis Radix may play important roles in the antiallodynic action of GJG.…”

Section: Discussionmentioning

confidence: 99%

Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice

Andoh

Kitamura

Fushimi

et al. 2014

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

Peripheral neuropathy is a major dose-limiting side effect of the chemotherapeutic agent paclitaxel. This study examined whether the three related traditional herbal formulations, goshajinkigan (GJG; 牛車腎氣丸 Niú Chē Shèn Qì Wán), hachimijiogan (HJG; 八味地黃丸 Bā Wèi Dì Huáng Wán), and rokumigan (RMG; 六味丸 Liù Wèi Wán), would relieve paclitaxel-induced mechanical allodynia in mice. A single intraperitoneal injection of paclitaxel (5 mg/kg) induced mechanical allodynia, which peaked on day 14 after injection. On day 14 after paclitaxel injection, oral administration of GJG (0.1-1.0 g/kg) produced a significant inhibition of established allodynia, but HJG and RMG did not affect the allodynia. Repeated oral administration of GJG (0.1-1.0 g/kg) starting from the day after paclitaxel injection did not affect allodynia development, but significantly inhibited allodynia exacerbation. Repeated oral administration of HJG produced a slight inhibition of allodynia exacerbation, but that of RMG did not. These results suggest that prophylactic administration of GJG is effective in preventing the exacerbation of paclitaxel-induced allodynia. The herbal medicines Plantaginis Semen (車前子 Chē Qián Zǐ) and Achyranthis Radix (牛膝 Niú Xī), which are present in GJG but not in HJG, may contribute to the inhibitory action of GJG on the exacerbation of paclitaxel-induced allodynia.

show abstract

Efficacy of Toki-shigyakuka-gosyuyu-syokyo-to (Danggui-Sini-Jia-Wuzhuyu-Shengjiang-Tang) on Peripheral Circulation in Autonomic Disorders

Cited by 23 publications

References 0 publications

Efficacy of Static Magnetic Field for Locomotor Activity of Experimental Osteopenia

Efficacy of Static Magnetic Field for Locomotor Activity of Experimental Osteopenia

Herbal Prescription, DSGOST, Prevents Cold‐Induced RhoA Activation and Endothelin‐1 Production in Endothelial Cells

Effects of Goshajinkigan, Hachimijiogan, and Rokumigan on Mechanical Allodynia Induced by Paclitaxel in Mice

Contact Info

Product

Resources

About