Efficacy of topical 5% fluorouracil needling in vitiligo

Gandhi, Sneha; Murugesh, S B; Kusagur, Mamatha S; Sugareddy,

doi:10.4103/ijdvl.ijdvl_386_16

Cited by 14 publications

(8 citation statements)

References 4 publications

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“…Gandhi et al (2018) demonstrated that response to micro needling combined with5-FU was excellent in 49% and very good in 26%. Side effects were: pain 100%, erythema (52%), itching (52%) and Kobner , s phenomenon (1%) [14].…”

Section: Discussionmentioning

confidence: 99%

“…Vimala et al, (2012) demonstrated that micro needling combined with5-FU is efficient in treatment stable vitiligo in which total repigmentation was observed in 71.4% and partial repigmentation in 28.6% without any significant side effects [13]. Gandhi et al (2018) demonstrated that response to micro needling combined with5-FU was excellent in 49% and very good in 26%. Side effects were: pain 100%, erythema (52%), itching (52%) and Kobner , s phenomenon (1%) [14].…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of topical 5% fluorouracil (5%- FU) needling in vitiligo

Ibrahiem¹

2021

Journal of Medical and Pharmaceutical Sciences

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Objective: The aim of this study is to assess the efficacy of topical 5- fluorouracil (5%- FU) with micro needling in treating stable vitiligo. In addition to, assessment the side effects of the treatment. Patients and Methods: A Prospective study (Before& After) conducted for the period one year (April 2019- April2020)at Tishreen University Hospital in Lattakia- Syria, 31 patients with stable vitiligo who received treatment with micro needling and topical 5- fluorouracil (5%- FU) were included in this study. Results : The median age was 36 years, 67.70% of patients were female. Focal type was found in 61.3%, and most common sites of vitiligo involvement were hand and feet (33.7%), followed by trunk (24.8%)and extremities (24.8%). After 6 months of treatment, improvement was excellent in 63.4%, and very good in 23.8%. The lesions of neck and trunk were responded better to treatment than those in other parts of the body. Regarding of side effects, pain, erythema, and itching were reported in 100% followed by ulceration in (16.1%). Conclusion: Topical 5%- fluorouracil (5%- FU) with needling appears to be an effective and safe method in treating stable vitiligo. Except of pain, erythema, and itching after procedure, significant complications not occurred in most patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of topical 5% fluorouracil (5%- FU) needling in vitiligo

Ibrahiem¹

2021

Journal of Medical and Pharmaceutical Sciences

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“…An open, nonrandomized, single-arm study was done by Shashikiran et al . [ 14 ] to observe the safety and efficacy of needling followed by topical 5% 5-FU application on patches of vitiligo. This procedure was done every 15 days for 3 consecutive months similar to our study.…”

Section: Discussionmentioning

confidence: 99%

“…A study done by Shashikiran et al . [ 14 ] reported that out of 39 patients, 23 (58.97%) had vitiligo vulgaris, 13 (33.33%) had acrofacial, and 3 (7.70%) had focal vitiligo. A comparative study done by Mina et al .…”

Section: Discussionmentioning

confidence: 99%

Effect of Topical 5% 5-Fluorouracil with Microneedling in Vitiligo Patients as an Additional Modality to Standard Treatment at Tertiary Care Hospital

Desai,

Momin,

Vaishnani

2024

Indian Dermatology Online Journal

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Background: Vitiligo is an inveterate disease of great aesthetic concern presenting with depigmented macules and patches. It is often incorrigible to medical treatment. Aim: To study the clinical profile of vitiligo patients and evaluate the effect of 5% 5-fluorouracil (5-FU) cream with microneedling. Materials and Methods: This observational analytical study was conducted from November 2019 to July 2021. A total of 33 adult vitiligo patients were treated with oral mini-pulse (dexamethasone) therapy and topical corticosteroid (clobetasol propionate 0.05%). Patient’s total number of vitiligo lesions with <10-cm size were counted and half of the lesions were treated with 5-FU + microneedling (Group A), while a remaining number of lesions were not treated with 5-FU + microneedling (Group B). In the case of the odd number of lesions, the total number of lesions minus one was considered and then divided into equal numbers for treatment. The procedure was performed every 2 weeks for 3 months. Clinical improvement was assessed monthly till 6 months by serial clinical photographs and grading scores. Results: Initiation of repigmentation started in the first month in Group A, whereas in Group B, it was seen in the second, which was statistically significant (P < 0.0001). Excellent improvement (>75% repigmentation) was noted in Group A as compared to Group B at the end of 6 months (P < 0.0001). Conclusions: Needling with 5% 5-FU appears to be a simple, safe, and effective treatment in vitiligo. It can be used in poor responders to conventional therapy.

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“…In a study by Kumar et al 28 the use of micro‐needling and 5‐FU in treating vitiligo showed 75 to 90% repigmentation after six sessions, of which one patient showed complete repigmentation. The study by Shashikiran et al 29 investigating the effect of topical 5‐FU plus needling, showed that 49% of the patches had more than 75% repigmentation, and 26% of the patches had between 50% and 75% repigmentation. In the present study, six patients in the micro‐needling plus 5‐FU group reported an appropriate response, and three showed more than 75% repigmentation.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of adding topical 5‐fluorouracil to micro‐needling in the treatment of vitiligo: A randomized controlled trial

Pazyar

Hatami

Yaghoobi

et al. 2023

J of Cosmetic Dermatology

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Background and Aim Vitiligo is an autoimmune skin disorder characterized by circumscribed depigmented macules and patches caused by the loss of functional melanocytes. Although there is no definitive treatment for vitiligo, several treatment options have been associated with relative satisfactory outcomes. The purpose of this study was to compare the efficacy of micro‐needling in conjunction with topical 5‐fluorouracil (5‐FU) versus topical tacrolimus ointment in treating vitiligo patches. Patients and Methods This study included nineteen participants, each of whom received both treatments on two randomly selected vitiligo patches of approximately the same size and location. On one patch, a combination of weekly micro‐needling and topical application of 5‐FU solution was used every other day, while on the other, 0.1% tacrolimus topical ointment was applied twice daily. The G‐score was used to compare treatment outcomes after 3 months. Results The median duration of the disease in our population was 7 years. Six patients (32%) in the micro‐needling plus topical 5‐FU treated group showed a moderate to excellent response, indicating a significant improvement between both treatments (p‐value = 0.019). In contrast, all other patches treated with topical tacrolimus showed poor improvement. Lower extremity and trunk responded more to treatment with micro‐needling plus topical 5‐FU than upper extremity and acral areas. Moreover, none of those who have had the disease for more than ten years have responded to treatment. Mild erythema, pinpoint bleeding, and irritation were detected only in the micro‐needling treated group. Conclusion The current study showed that using micro‐needling in conjunction with 5‐FU could treat vitiligo patients more efficiently than tacrolimus monotherapy. Despite showing moderate to excellent improvement in patches treated with micro‐needling and 5‐FU, this well‐tolerated office‐based modality still requires additional research.

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Efficacy of topical 5% fluorouracil needling in vitiligo

Cited by 14 publications

References 4 publications

Efficacy of topical 5% fluorouracil (5%- FU) needling in vitiligo

Efficacy of topical 5% fluorouracil (5%- FU) needling in vitiligo

Effect of Topical 5% 5-Fluorouracil with Microneedling in Vitiligo Patients as an Additional Modality to Standard Treatment at Tertiary Care Hospital

The efficacy of adding topical 5‐fluorouracil to micro‐needling in the treatment of vitiligo: A randomized controlled trial

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