Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

Heidari, Mohammad; Bahramsoltani, Roodabeh; Abdolghaffari, Amir Hossein; Rahimi, Roja; Esfandyari, Mohammadamin; Baeeri, Maryam; Hassanzadeh, Gholamreza; Abdollahi, Mohammad; Farzaei, Mohammad Hosein

doi:10.1016/j.jtcme.2018.02.002

Cited by 38 publications

(24 citation statements)

References 29 publications

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“…Among these, the applications of plant based nanotechnology plays a significant role in the process of wound healing [16,17]. The plant based materials have proved at all times to be a powerful remedy for health care [18][19][20][21][22][23][24][25][26][27]. Accordingly, the grape seed extract containing PCs have been investigated for wound treatment and in the management of many illnesses such as cancers, cardiovascular disease, gastric ulcers, obesity and skin inflammations.…”

Section: Introductionmentioning

confidence: 99%

Nano formulated proanthocyanidins as an effective wound healing component

Ramesh

Volova

Oluwafemi

et al. 2020

Materials Science and Engineering: C

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Proanthocyanidins (PCs), a component of grape seed extract (GSE), has recently being used for the treatment of wounds. However, poor absorption, poor stability and rapid elimination from the systemic circulation limit its acceptance. In addressing these problems, we herein report the development of PCs based nanoformulations (PCs/SOLU) for the first time based on 1 % GSE and assessed its wound healing potential in-vivo on the wistar rats. GSE and PCs/SOLU nanodispersions 1 % were prepared by incorporating them into the ointment base via uniform mixing to form ointment which could be easily applied topically to wounds. The antibacterial activity of PCs/SOLU against gram positive and gram-negative bacteria strains proved that the cell membranes became more permeable with disrupted cell structure. While carrageenan and histamine induced rat paw edema analyses show there was no inflammatory signs in animals treated with 1 wt% of PCs/SOLU nanodispersion. Excision wound measuring about 3 cm in depth was created on the wistar rats. The ointment was applied topically on the wounded site and the wound contraction was measured daily. Grape seed extract (GSE) ointment, ointment base and povidone-iodine (Povi-Iod) ointment of about 1 % was used as the control, positive and negative standards. PCs/SOLU nanodispersion heals the wound by mobilising the fibroblasts in the wound site and inhibits the inflammatory response through decreased expression of monocyte. The macroscopical, immunological and histopathological assessments revealed that PCs/SOLU nanodispersion ointment usage improves the cell adhesion and proliferation

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Section: Introductionmentioning

confidence: 99%

Nano formulated proanthocyanidins as an effective wound healing component

Ramesh

Volova

Oluwafemi

et al. 2020

Materials Science and Engineering: C

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“…54 The pathophysiological activity of Lobelia alsinoides on wound healing in humans and rats using plant extract mediated treatments has been compared with the various preclinical and controlled, randomized and blinded clinical trials previously reported. [55][56][57][58][59][60][61][62][63][64][65][66][67] Though there is no literature reporting on the healing properties patients. 64,72 There are some limitations to this study.…”

Section: Discussionmentioning

confidence: 99%

“…The pathophysiological activity of Lobelia alsinoides on wound healing in humans and rats using plant extract mediated treatments has been compared with the various preclinical and controlled, randomized and blinded clinical trials previously reported 55‐67 …”

Section: Discussionmentioning

confidence: 99%

Efficacy ofLobelia alsinoidesLam ethanolic extract on a third‐degree burn: An experimental study on rats

Thanapaul

Ranjan

Manikandan

et al. 2020

Dermatologic Therapy

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This is the first study to evaluate the topical application of Lobelia alsinoides Lam (LT) ethanolic extract on burns in rats. A deep third-degree burn wound was inflicted in adult male Wistar rats and the burns were dressed daily with a topical ointment formulation (Patent filed) comprising of Lobelia alsinoides Lam (5% and 10% w/w). The wound had noteworthy contraction and quicker eschar removal in 10% w/w LTtreated groups followed by 5% w/w treated groups on comparing with the commonly prescribed ointment (Silverex TM containing 1% w/w Silver sulfadiazine). Histopathological analysis showed that ointment containing 10% w/w LT ethanolic extract significantly increased fibroblast growth, which plays a major role in anatomic integrity, collagen synthesis, and accelerated the rate of the healing process. This study shows that the ethanolic extract of Lobelia alsinoides Lam, a previously pharmacologically unreported traditional medicinal plant, possesses wound contraction and eschar removal properties on burn wounds.

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“…20 A 2 × 2 cm area of skin was excised from the epidermal layer to the subcutaneous layer as well as the connective tissue below it. Wound healing rate was calculated according to Heidari et al.. 21 This study followed the standard of ethics of Health Law research number 23/1992 and obtained ethical approval number 1175/H25.1.11/KE/2017 from the Faculty of Medicine, University of Jember.…”

Section: Methodsmentioning

confidence: 99%

Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats

Marchianti

Sakinah

Elfiah

et al. 2021

Journal of Traditional and Complementary Medicine

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Background and aim The treatment of diabetic ulcers is difficult because of defective blood vessels and frequent co-occurrence of bacterial infections. In a previous study, we found a water fraction of Merremia mammosa (Lour.) (Mm(Lour.)) had beneficial effects on wound healing in diabetic rats. This study aimed to evaluate the influence of different gelling agents added to Mm(Lour.) water fraction gel on wound healing treatment in diabetic rats. Experimental procedure Diabetic Wistar rats were divided into the following five groups: 1. positive control (Neomycin Sulfate 0.5% and Placenta Extract 10%), 2. negative control (distilled water), and 10% water fraction of Mm(Lour.) extract in 3. HPMC, 4. Carbopol, and 5. CMC Na gelling agents. The wound was made by the Morton method and treatment applied every other day for 25 days, then the wound healing process was observed. Data were observed and analysed using appropriate statistic tools. Results Histopathology observation, VEGF expression and hydroxyproline levels showed a significant acceleration of wound healing in all treatment groups compared to the negative control group. This study showed all of Mm(Lour.) gel formulations could restore the delayed healing process on wound in diabetic rats and were equally effective in accelerating wound healing. CMC Na was the most preferable because it did not irritate. Conclusion The results suggest that Mm(Lour.) water fraction in CMC Na gelling agent provided an option to be developed as a topical drug on diabetic wound healing treatment, showed by enhancement of collagen synthesis and angiogenesis.

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Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

Cited by 38 publications

References 29 publications

Nano formulated proanthocyanidins as an effective wound healing component

Nano formulated proanthocyanidins as an effective wound healing component

Efficacy ofLobelia alsinoidesLam ethanolic extract on a third‐degree burn: An experimental study on rats

Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats

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