Efficacy of Topical Nonsteroidal Antiinflammatory Drugs in Mastalgia Treatment

Çolak, Tahsin; İpek, Turgut; Kanık, Arzu; Ogetman, Zekai; Aydın, Serdar

doi:10.1016/s1072-7515(02)01893-8

Cited by 68 publications

(44 citation statements)

References 33 publications

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“…The benefit was seen in both cyclical and noncyclical breast pain. No side effect was reported in any group [23].…”

Section: Simple Medicationsmentioning

confidence: 76%

“…& Vitamins: There is no convincing evidence to support the use of vitamins in treatment of mastalgia; however, vitamin B 1 , B 6 , and E are all used by clinicians. These have no role and should not be misused [23]. A recent meta-analysis described that long-term use of vitamin E may increase risk of hemorrhagic stroke (RR=1.22; 95 % confidence interval 1 to 1.48; p=0.045) [19].…”

Section: Reassurancementioning

confidence: 99%

“…Diclofenac gel applied as local massage to painful areas of breast has been found to be more effective than placebo gel and ibuprofen gel in randomized trials [23].…”

Section: Simple Medicationsmentioning

confidence: 99%

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A Systematic Review of Current Understanding and Management of Mastalgia

et al. 2013

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Breast pain or mastalgia is the common symptom in the breast. The two most common concerns of patients presenting with mastalgia are: the fear that breast pain is a symptom of breast cancer and the presence of severe pain that affects a woman's quality of life. Breast pain requires thorough assessment and should be investigated in the same manner as any other breast symptom. We conducted a systematic review of treatment for breast pain. We searched various reviews, randomized controlled trial, and observational studies over Pubmed and Medline via internet. Searches were carried out on MEDLINE

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“…The benefit was seen in both cyclical and noncyclical breast pain. No side effect was reported in any group [23].…”

Section: Simple Medicationsmentioning

confidence: 76%

Section: Reassurancementioning

confidence: 99%

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A Systematic Review of Current Understanding and Management of Mastalgia

et al. 2013

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“…The drug therapy includes agents inducing hormonal manipulation such as Danazol [4], Bromocriptine [5], Tamoxifen [6], and LH-RH [7] analogue like Goserelin. Some of the effective non-hormonal agents in mastalgia are Non-steroidal anti-inflammatory gels [8], reassurance [9] and breast support with sport's bra [10].…”

Section: Introductionmentioning

confidence: 99%

Centchroman Regresses Mastalgia: A Randomized Comparison with Danazol

et al. 2010

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We conducted a randomized trial to evaluate effectiveness of Centchroman in control of mastalgia and compared it with Danazol. Research Question-Is proportion of pain relief achieved by Centchroman similar to or inferior to that achieved by Danazol? In a randomized controlled trial of Centchroman vs. Danazol in mastalgia, 81 patients with mastalgia were studied. Thirty-nine patients were randomized to Danazol arm and 42 in Centchroman arm. The treatment was given for 12 weeks, followed by observation for 12 weeks. The pain was measured by visual analogue scale (VAS) of 0-10. At 12 weeks 89.7% women achieved reduction in pain score to ≤3 in Centchroman group (pvalue 0.001). In Danazol group 69.44% women achieved reduction in pain score to ≤ 3 (p=0.001). Three months after stopping therapy, Centchroman was more effective in pain score reduction at 24 weeks as compared to Danazol (p=0.019). Centchroman is an effective, safe and inexpensive alternative to Danazol for treatment of mastalgia.

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“…Опу-бликовано много работ по применению масла при-мулы вечерней для лечения масталгии, однако поло-жительные и отрицательные результаты распредели-лись поровну [6]. Также неоднозначны данные об эффективности обычных нестероидных противовос-палительных средств [15][16][17], оральных контрацеп-тивов [18,19], и даже таких препаратов, как бромо-криптин [20,21] и тамоксифен [22,23]. Общая такти-ка лечения масталгии заключается в назначении препаратов с наименьшим количеством побочных эффектов с тем, чтобы более сильные и токсичные препараты, такие как даназол и бромокриптин, оста-вить для рефрактерных случаев.…”

Section: рис 1 схема строения молочной железыunclassified