Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

Cheng, Jing; Zheng, Jia; Liu, Yanping; Hao, Panpan

doi:10.1042/bsr20181729

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…The most typical example of this is the excellent efficacy of TCMs in the management of type 2 diabetes (T2D) (Xu et al, 2015; Nie et al, 2018; Tong et al, 2018; Cheng F. R. et al, 2019; Cheng J. et al, 2019; Han et al, 2019; Li et al, 2019; Lu et al, 2019; Shi et al, 2019; Wu et al, 2019; Yuan et al, 2019). The major component of HMs, such as the polysaccharides extracted from Hirsutella sinensis , provides nutrition to specific bacteria, thereby modulating the constitution of the intestinal microbiota to improve T2D (Xu et al, 2015, 2017; Nie et al, 2018; Tong et al, 2018; Wu et al, 2019; Table 3).…”

Section: Gut Microbes: Crucial Factors For the Function Of Tcmmentioning

confidence: 99%

Intestinal Microbiota-Associated Metabolites: Crucial Factors in the Effectiveness of Herbal Medicines and Diet Therapies

et al. 2019

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Although the efficacy of herbal medicines (HMs) and traditional Chinese medicines (TCMs) in human diseases has long been recognized, their development has been hindered in part by a lack of a comprehensive understanding of their mechanisms of action. Indeed, most of the compounds extracted from HMs can be metabolized into specific molecules by host microbiota and affect pharmacokinetics and toxicity. Moreover, HMs modulate the constitution of host intestinal microbiota to maintain a healthy gut ecology. Dietary interventions also show great efficacy in treating some refractory diseases, and the commensal microbiota potentially has significant implications for the high inter-individual differences observed in such responses. Herein, we mainly discuss the contribution of the intestinal microbiota to high inter-individual differences in response to HMs and TCMs, and especially the already known metabolites of the HMs produced by the intestinal microbiota. The contribution of commensal microbiota to the inter-individual differences in response to dietary therapy is also briefly discussed. This review highlights the significance of intestinal microbiota-associated metabolites to the efficiency of HMs and dietary interventions. Our review may help further identify the mechanisms leading to the inter-individual differences in the effectiveness of HM and dietary intervention from the perspective of their interactions with the intestinal microbiota.

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Section: Gut Microbes: Crucial Factors For the Function Of Tcmmentioning

confidence: 99%

Intestinal Microbiota-Associated Metabolites: Crucial Factors in the Effectiveness of Herbal Medicines and Diet Therapies

et al. 2019

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“…Gastrodia elata Blume (GEB) water extract [58] dose-dependently improved hypothalamic insulin signaling, enhanced systemic insulin sensitivity during a euglycemic hyperinsulinemic clamp, and increased insulin secretion under high glucose stimulation. Tangminling (TML) pills [59]mainly contain Rhizoma coptidis , Rheum officinale Baill, Scutellaria baicalensis Georgi, and Bupleurum chinense DC and might improve β cell function in T2DM patients. Tianmai Xiaoke Pian ( TMXKP ) [60] is composed of Tianhuafen, Maidong, and Wuweizi and could improve ischemia-reperfusion through the PI3K/AKT pathway.…”

Section: Other Functionsmentioning

confidence: 99%

Advances in Research on the Protective Mechanisms of Traditional Chinese Medicine (TCM) in Islet β Cells

Zhang

2019

Evidence-Based Complementary and Alternative Medicine

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The dysfunction and decreased number of islet β cells are central to the main pathogenesis of diabetes. Improving islet β cell function and increasing the number of β cells are effective approaches to treat diabetes and constitute the main direction of diabetes drug development. The role of Chinese medicine in the treatment of diabetes began to be recognized. In recent years, Chinese medicine monomers have been found to increase insulin synthesis and secretion, reduce β cell-apoptosis, and protect the function of β cells. The results of in vivo animal experiments and in vitro studies on insulinoma cells also suggested TCMs could promote the proliferation of pancreatic islet β cells and induce other cells differentiation or transdifferentiation to islet β cells. Thereby, they may play a role in the treatment of diabetes. In this paper, we will review islet β cell protection with TCMs and the related mechanisms found in recent studies. An in-depth explanation of the role of TCM in islet β cell protection can provide a theoretical basis and research ideas for the development of TCM-based diabetes treatment drugs.

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“…Diabetes mellitus is a common disease that endangers human health, and the age of patients with diabetes has shown a trend of getting younger . Diabetes causes a variety of complications such as microvascular diseases, seriously affects the quality of life of the patients, and imposes enormous mental and economic burdens on the patients and their families . Early prevention is one of the important measures to alleviate the harm of diabetes.…”

Section: Introductionmentioning

confidence: 99%

A compound reflects the level of homocysteine based on Rhodamine B and its ability to respond to homocysteine in the plasma of diabetic patients

Zhao

Cheng

Zhu

2020

Clinical Laboratory Analysis

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Background:The level of homocysteine (Hcy) is significantly elevated in the plasma of patients with diabetes. The increased plasma Hcy level is positively correlated with the severity of the disease and is one of the important causes of diabetic complications. Methods:We designed and synthesized a compound could reflect the level of Hcy based on rhodamine B, and the structure was verified by 1H-NMR and EI-HRMS.Then, the linearity, repeatability, selectivity, and cellar toxicity, the effects of the fluid viscosity and pH of compound on Hcy were measured; meanwhile, the response of Hcy level in the plasma of diabetic patients was detected.Results: This is a novel compound that has never been reported. The compound showed a satisfactory linear range and repeatability at the viscosity and pH of physiological fluid. In addition, the compound was capable of evading the interference from other amino acids and metal ions, and it exhibited high selectivity toward Hcy. Conclusion:The compound showed increased responsiveness to plasma Hcy in patients with diabetes in comparison with healthy individuals and effectively reflected plasma Hcy levels in healthy individuals and diabetic patients. Therefore, the compound is expected to be used in the diagnosis of diabetes mellitus. K E Y W O R D Sdiabetic patients, homocysteine, rhodamine B

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Efficacy of traditional Chinese medication Tangminling pill in Chinese patients with type 2 diabetes

Cited by 4 publications

References 62 publications

Intestinal Microbiota-Associated Metabolites: Crucial Factors in the Effectiveness of Herbal Medicines and Diet Therapies

Intestinal Microbiota-Associated Metabolites: Crucial Factors in the Effectiveness of Herbal Medicines and Diet Therapies

Advances in Research on the Protective Mechanisms of Traditional Chinese Medicine (TCM) in Islet β Cells

A compound reflects the level of homocysteine based on Rhodamine B and its ability to respond to homocysteine in the plasma of diabetic patients

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