Efficacy of traditional Chinese Medicine for gastric precancerous lesion: A meta-analysis of randomized controlled trials

Chen, Xu; Dai, Yunkai; Zhang, Yunzhan; Liu, Fengbin; Lan, Shaoyang; Wang, Shuangshuang; Hu, Ling; Li, Peiwu

doi:10.1016/j.ctcp.2019.101075

“…Traditional Chinese medicine had complementary and alternative effect which is indispensable[ 36 ]. A meta-analysis indicated that traditional Chinese medicine is more effective than current routine pharmacotherapy in clinical symptom relief, H. pylori eradication, and efficacy under endoscopy[ 37 ]. Thus, LTEVB 12 initial therapy and celecoxib rescue therapy actually enhance the regression rate of gastric mucosal lesions with few adverse effects and toxic side effects.…”

Section: Discussionmentioning

confidence: 99%

Lamb’s tripe extract and vitamin B₁₂capsule plus celecoxib reverses intestinal metaplasia and atrophy: A retrospective cohort study

Wu¹,

Liu²,

Zhang³

et al. 2021

WJCC

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BACKGROUND Chronic atrophic gastritis (AG) with intestinal metaplasia (IM) significantly increases the risk of gastric cancer. Some medicines have showed definite therapeutic effects in AG and IM regression. AIM To validate the efficacy of Lamb’s tripe extract and vitamin B 12 capsule (LTEVB 12 ) initial therapy and celecoxib rescue therapy for IM and AG. METHODS A total of 255 patients were included to receive LTEVB 12 initial therapy (2 capsules each time, three times daily for 6 mo) in hospital in this study. The patients with failure of IM regression continued to receive celecoxib rescue therapy (200 mg, once daily for 6 mo). After each therapy finished, the patients underwent endoscopy and biopsy examination. The regression efficiency was assessed by the operative link on gastritis assessment (OLGA) and the operative link on the gastric intestinal metaplasia assessment (OLGIM) staging system. Logistic regression analysis was applied to identify factors associated with the curative effect. RESULTS For LTEVB 12 initial therapy, the reversal rates of IM and AG were 52.95% and 48.24%, respectively. Analogously, for celecoxib rescue therapy, the effective rates for IM and AG were 56.25% and 51.56%, respectively. The IM regression rate of complete therapy was up to 85.03%. In different OLGA and OLGIM stages of IM patients, therapeutic efficiency showed a significant difference in each group ( P < 0.05). For both therapies, patients with high stages (III or IV) of both the OLGA and OLGIM evaluation systems showed a higher IM or AG regression rate than those with low stages (I or II). Among patients with high stages (OLGIM III and IV), the IM regression rate was above 70% for each therapy. Eating habits, fresh vegetable intake, and high-salt diet were identified as independent factors for the IM reversal effect of LTEVB 12 therapy, especially high-salt diet (odds ratio = 1.852, P < 0.05). CONCLUSION Monotherapy could reverse IM and AG. LTEVB 12 initial therapy and celecoxib rescue therapy significantly increase the regression effect. IM may not be the point of no return among gastric precancerous lesions.

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“…Specifically, these include: (1) The extraction of active ingredients of TCM has not yet been performed; (2) pharmacological research on single Chinese herbs and compound preparations remains to be performed; (3) the mechanism of H. pylori eradication has not been fully revealed; (4) studies relating to TCM are largely based on small sample sizes which fail to establish a complete H. pylori eradication treatment plan; (5) some medicines do not meet the requirements of finished medicines; and (6) diverse lifestyles and diets from different regions may affect responses. The corresponding solutions to these problems are illustrated in Figure 1 [ 62 - 67 ], yet there remain many obstacles towards completely resolving these problems.…”

Section: Problems and Solutions Encountered By Tcm In Treatment Of H Pylori Infectionmentioning

confidence: 99%

Application of traditional Chinese medicine in treatment of Helicobacter pylori infection

Li¹,

Dai²,

Qin³

et al. 2021

WJCC

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Helicobacter pylori ( H. pylori ) has a high rate of infection and antibiotic resistance and poses a serious threat to human life. One of the main strategies to overcome drug resistance is to develop new treatment plans. Traditional Chinese medicine (TCM) that is commonly used to treat many diseases in China can reduce drug resistance and increase the eradication rate of H. pylori . In this paper, we review the research progress on TCM in the treatment of H. pylori infection. The mechanism of action of TCM is reviewed and research and applications of TCM in the treatment of H. pylori are demonstrated. Finally, we discuss problems confronting the use of TCM for the treatment of H. pylori infection and propose possible solutions. In addition, the plans of TCM in H. pylori treatment were also screened: Dampness-heat syndrome in the spleen and stomach, deficiency of spleen and stomach, and cold-heat complicated syndrome, and the effective components therein are studied. The antibacterial effect of TCM is relatively slow; for rapid improvement of the treatment effect of refractory H. pylori gastritis, we provide an appropriate treatment regime combining TCM and Western medicine with immune-regulatory and synergistic antibacterial effects.

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“…However, modern medicine still lacks ideal treatment for GPL. Numerous clinical reports have confirmed that traditional Chinese medicine (TCM) treatment can reduce and remove some intestinal epithelial metaplasia and dysplasia and has certain curative effect on both symptom improvement and pathological reversal [5].…”

Section: Introductionmentioning

confidence: 99%

Alterations of Microorganisms in Tongue Coating of Gastric Precancerous Lesion Patients with a Damp Phlegm Pattern

Xiao

¹

,

Zhang

²

,

Lü

³

et al. 2022

BioMed Research International

0

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Objective. In the research, the microbial changes in the tongue coating of patients with a damp phlegm pattern of gastric precancerous lesion (GPL) were investigated. Methods. This was a case-control study, in which 80 tongue coating samples were collected including 40 patients with a damp phlegm pattern of GPL, 20 patients with a nondamp phlegm pattern of GPL, and 20 healthy control people. The 16S rRNA microbiome technology was used to analyze the alterations of microorganisms in tongue coating of GPL patients with a damp phlegm pattern. Results. Microorganisms in the genus level were analyzed. Compared with the healthy control group, the relative abundance of 4 microorganisms (Solobacterium, Rothia, Oribacterium, and Alloprevotella) in the GPL group was significantly higher ( P < 0.05 ). The relative abundance of 10 microorganisms (Terrisporobacter, Solobacterium, Porphyromonas, Parvimonas, Lactobacillus, Johnsonella, Gemella, Fusibacter, Azoarcus, and Acidothermus) in the GPL damp phlegm pattern group was significantly lower than that in the GPL nondamp phlegm pattern group ( P < 0.05 ). In the comparison of phenotype “forms biofilms,” the relative abundance of microorganisms in the GPL group was significantly higher than that in the healthy control group ( P < 0.05 ). In the comparison of phenotype “contains mobile elements,” the relative abundance of microorganisms in the GPL damp phlegm pattern group was significantly lower than that in the GPL nondamp phlegm pattern group ( P < 0.05 ). In the comparison of microbial metabolic functions, the abundance ratio of “infectious diseases: bacterial” in the GPL group was significantly lower than that in the healthy control group ( P < 0.05 ). The abundance ratio of the “excretory system” and “folding, sorting, and degradation” in the GPL group was significantly higher than that in the healthy control group ( P < 0.05 ). Conclusions. Solobacterium may be a marker microorganism of the GPL damp phlegm pattern. The differential phenotype of microorganisms in tongue coating of the GPL damp tongue pattern is mainly reflected in “forms biofilms” and “contains mobile elements.”

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Efficacy of traditional Chinese Medicine for gastric precancerous lesion: A meta-analysis of randomized controlled trials

Cited by 3 publications

References 24 publications

Lamb’s tripe extract and vitamin B₁₂capsule plus celecoxib reverses intestinal metaplasia and atrophy: A retrospective cohort study

Lamb’s tripe extract and vitamin B₁₂capsule plus celecoxib reverses intestinal metaplasia and atrophy: A retrospective cohort study

Application of traditional Chinese medicine in treatment of Helicobacter pylori infection

Alterations of Microorganisms in Tongue Coating of Gastric Precancerous Lesion Patients with a Damp Phlegm Pattern

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Efficacy of traditional Chinese Medicine for gastric precancerous lesion: A meta-analysis of randomized controlled trials

Cited by 3 publications

References 24 publications

Lamb’s tripe extract and vitamin B12 capsule plus celecoxib reverses intestinal metaplasia and atrophy: A retrospective cohort study

Lamb’s tripe extract and vitamin B12 capsule plus celecoxib reverses intestinal metaplasia and atrophy: A retrospective cohort study

Application of traditional Chinese medicine in treatment of Helicobacter pylori infection

Alterations of Microorganisms in Tongue Coating of Gastric Precancerous Lesion Patients with a Damp Phlegm Pattern

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Product

Resources

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Lamb’s tripe extract and vitamin B₁₂capsule plus celecoxib reverses intestinal metaplasia and atrophy: A retrospective cohort study

Lamb’s tripe extract and vitamin B₁₂capsule plus celecoxib reverses intestinal metaplasia and atrophy: A retrospective cohort study