Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo

Kurokawa, Mineo; Nagasaka, Kazuhiko; Hirabayashi, Tatsuji; Uyama, Shin-ichi; Sato, Hideki; Kageyama, Takashi; Kadota, Shigetoshi; Ohyama, Haruo; Hozumi, Toyoharu; Namba, Tsuneo; Shiraki, Kimíyasu

doi:10.1016/0166-3542(94)00076-k

Cited by 124 publications

(91 citation statements)

References 39 publications

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“…The methanol and aqueous extracts of T. chebula showed a significant inhibitory activity with IC 50曑 5 µg/mL on human immunodeficiency virus-1 reverse transcriptase [66] . It also demonstrated the therapeutic activity against herpes simplex virus both in vitro and in vitvo tests [67] . These finding prompted a team of Japanese researchers to investigate T. chebulas's effect on human cytomagalovirus (CMV).…”

Section: Antifungal Activitymentioning

confidence: 96%

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Bag

Bhattacharyya

Chattopadhyay

2013

Asian Pacific Journal of Tropical Biomedicine

262

180

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Section: Antifungal Activitymentioning

confidence: 96%

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Bag

Bhattacharyya

Chattopadhyay

2013

Asian Pacific Journal of Tropical Biomedicine

262

180

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“…Eugenol is also effective against clinical isolates of HSV-1 [45]. Unfortunately, it has been found that cytotoxicity of eugenol as a single compound is negligible against HSV-1, but in combination with acyclovir exhibits a promising antiviral property [46]. This compound also acts against human cytomegalovirus (CMV), murine CMV (MCMV) and hepatitis C virus (≥ 90% inhibition at 100 µg/mL) [47][48].…”

Section: Antiviral Activitymentioning

confidence: 99%

Versatile and Synergistic Potential of Eugenol: A Review

Raja¹

2015

Pharm Anal Acta

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Eugenol (1-allyl-4-hydroxy-3-methoxybenzene) is the phenolic component of essential oil and the main constituent of Eugenia caryophyllata, Ocimmum gratissimum and several others medicinal plant. In view of its nonmutagenic and non-carcinogenic properties, eugenol is generally regarded as safe by the Food and Agricultural Organization of the United Nations. Eugenol has been recently shown to be effective for antimicrobials and treatment of different life threatening diseases including sepsis, leishmaniasis, and cancer. However overall, activity of eugenol is not discussed elsewhere. In this review, we discuss the current understanding of the mechanisms involved the antioxidant, antimicrobial, anticancer and anti-inflammatory potential of eugenol.

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“…A methanolic fruit extract is antianaphylactic (Shin et al 2001) and an aqueous extract acts against herpes simplex virus ( Kurokawa et al 1995). An ethanolic fruit extract is antibacterial and antifungal (Bonjar 2004, Devkota et al 1999.…”

Section: Chebulic Myrobalan (E)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

346

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo

Cited by 124 publications

References 39 publications

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

The development of Terminalia chebula Retz. (Combretaceae) in clinical research

Versatile and Synergistic Potential of Eugenol: A Review

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

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