Efficacy of tramadol–acetaminophen tablets in low back pain patients with depression

Tetsunaga, Tomoko; Tetsunaga, Tomonori; Tanaka, Masato; Ozaki, Toshifumi

doi:10.1007/s00776-014-0674-4

Cited by 31 publications

(26 citation statements)

References 29 publications

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“…We previously reported antidepressant-like effects of tramadol-acetaminophen in chronic LBP patients with depression [ 12 ]. The μ -opioid agonist activity of tramadol conceivably plays a role in mood improvement [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain

Tetsunaga

Tanaka

et al. 2016

Pain Research and Management

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Background. The contribution of apathy, frequently recognized in individuals with neurodegenerative diseases, to chronic low back pain (LBP) remains unclear. Objectives. To investigate levels of apathy and clinical outcomes in patients with chronic LBP treated with tramadol-acetaminophen. Methods. A retrospective case-control study involving 73 patients with chronic LBP (23 male, 50 female; mean age 71 years) treated with tramadol-acetaminophen (n = 36) and celecoxib (n = 37) was performed. All patients were assessed using the self-reported questionnaires. A mediation model was constructed using a bootstrapping method to evaluate the mediating effects of pain relief after treatment. Results. A total of 35 (55.6%) patients met the criteria for apathy. A four-week treatment regimen in the tramadol group conferred significant improvements in the Apathy scale and numerical rating scale but not in the Rolland-Morris Disability Questionnaire, Pain Disability Assessment Scale, or Pain Catastrophizing Scale. The depression component of the Hospital Anxiety and Depression Scale was lower in the tramadol group than in the celecoxib group. The mediation analysis found that the impact of tramadol-acetaminophen on the change in apathy was not mediated by the pain relief. Conclusions. Tramadol-acetaminophen was effective at reducing chronic LBP and conferred a prophylactic motivational effect in patients with chronic LBP.

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Section: Introductionmentioning

confidence: 99%

Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain

Tetsunaga

Tanaka

et al. 2016

Pain Research and Management

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“…A total of 18 methods for the treatment of acute and chronic LBP were reviewed by the assessment panel [ 2 3 4 10 11 12 13 14 15 16 17 18 19 ]. For acute LBP, several randomized trials and higher-quality systematic reviews found non-steroidal anti-inflammatory dru gs (NSAIDs), acetaminophen (AAP), and paracetamol superior for pain relief ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Benzodiazepines, muscle relaxants, tricyclic antidepressants, tapentadol, and pregabalin showed significant improvement of symptoms in seven high-quality studies as well as three clinical guidelines. Other pharmacological therapies were not supported by the references [ 1 2 4 11 16 17 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 ].…”

Section: Resultsmentioning

confidence: 99%

An Updated Overview of Low Back Pain Management in Primary Care

et al. 2017

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Currently, guidelines for lower back pain (LBP) treatment are needed. We reviewed the current guidelines and high-quality articles to confirm the LBP guidelines for the Korean Society of Spine Surgery. We searched available databases for high-quality articles in English on LBP published from 2000 to the present year. Literature searches using these guidelines included studies from MEDLINE, the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, and Embase. We analyzed a total of 132 randomized clinical trials, 116 systematic reviews, 9 meta-analyses, and 4 clinical guideline reviews. We adopted the SIGN checklist for the assessment of article quality. Data were subsequently abstracted by a reviewer and verified. Many treatment options exist for LBP, with a variety of recommendation grades. We assessed the recommendation grade for general behavior, pharmacological therapy, psychological therapy, and specific exercises. This information should be helpful to physicians in the treatment of LBP patients.

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“…In a study comparing celecoxib to tramadol, O’Donnell et al published that celecoxib 200 mg bid was superior to tramadol 50 mg qid in the relief of CLBP 43 . Four studies comparing tramadol, tramadol/acetaminophen, or tapentadol to an active comparator showed superiority in pain relief over the control group (oxycodone 44 , study drug plus pregabalin 45 , codeine/acetaminophen 46 , and NSAIDs 47 ).…”

Section: Findings From Studies Grouped By Chronic Pain Syndromementioning

confidence: 99%

Alternatives to Opioids in the Pharmacologic Management of Chronic Pain Syndromes: A Narrative Review of Randomized, Controlled, and Blinded Clinical Trials

Nicol

Hurley

Benzon

2017

Anesthesia &Amp; Analgesia

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Chronic pain exerts a tremendous burden on individuals and societies. If one views chronic pain as a single disease entity, then it is the most common and costly medical condition. At present, medical professionals who treat patients in chronic pain are recommended to provide comprehensive and multidisciplinary treatments, which may include pharmacotherapy. Many providers employ non-opioid medications to treat chronic pain, however, for some patients, opioid analgesics are the exclusive treatment of chronic pain. However, there is currently an epidemic of opioid use in the United States, and recent guidelines from the Centers for Disease Control (CDC) have recommended that the use of opioids for non-malignant chronic pain be used only in certain circumstances. The goal of this review was to report the current body of evidence-based medicine gained from prospective, randomized-controlled, blinded studies on the use of non-opioid analgesics for the most common non-cancer chronic pain conditions. A total of 9566 studies were obtained during literature searches and 271 of these met inclusion for this review. Overall, while many non-opioid analgesics have been found to be effective in reducing pain for many chronic pain conditions, it is evident that the number of high-quality studies is lacking and the effect sizes noted in many studies is not considered to be clinically significant despite statistical significance. More research is needed to determine effective and mechanisms-based treatments for the chronic pain syndromes discussed in this review. Utilization of rigorous and homogeneous research methodology would likely allow for better consistency and reproducibility, which is of utmost importance in guiding evidence-based care.

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Efficacy of tramadol–acetaminophen tablets in low back pain patients with depression

Cited by 31 publications

References 29 publications

Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain

Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain

An Updated Overview of Low Back Pain Management in Primary Care

Alternatives to Opioids in the Pharmacologic Management of Chronic Pain Syndromes: A Narrative Review of Randomized, Controlled, and Blinded Clinical Trials

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