Efficacy of transcranial alternating current stimulation in treating chronic insomnia and the impact of age on its effectiveness: A multisite randomized, double-blind, parallel-group, placebo-controlled study

Zhu, Xiaolin; Ren, Yanping; Tan, Shuping; Ma, Xin

doi:10.1016/j.jpsychires.2023.12.037

Journal of Psychiatric Research

2024

DOI: 10.1016/j.jpsychires.2023.12.037

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Efficacy of transcranial alternating current stimulation in treating chronic insomnia and the impact of age on its effectiveness: A multisite randomized, double-blind, parallel-group, placebo-controlled study

Xiaolin Zhu,

Yanping Ren,

Shuping Tan

et al.

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Cited by 4 publications

References 38 publications

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The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study

Shi,

Tian,

et al. 2025

Sleep Medicine

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The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study

Shi,

Tian,

et al. 2025

Sleep Medicine

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Transcranial direct current stimulation improves seizures frequency in drug-resistant epilepsy: A systematic-review and meta-analysis of randomized controlled trials

Lima,

Telles,

Dantas

et al. 2024

Epilepsy & Behavior

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The safety and efficacy of applying a high-current temporal interference electrical stimulation in humans

Wang,

Zeng,

Wang

et al. 2024

Front. Hum. Neurosci.

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BackgroundTemporal interference electrical stimulation (TI) is promise in targeting deep brain regions focally. However, limited electric field intensity challenges its efficacy.ObjectiveThis study aimed to introduce a high-current TI electrical stimulation protocol to enhance its intensity and evaluate its safety and efficacy when applied to the primary motor cortex (M1) in the human brain.MethodsSafety assessments included a battery of biochemical and neuropsychological tests (NSE, MoCA, PPT, VAMS-R, and SAS measurements), 5-min resting-state electroencephalography (EEG) recordings before and after 30-min high-current TI electrical stimulation sessions (20 Hz, 70 Hz, sham). Adverse reactions were also documented post-stimulation. Efficacy evaluations involved two motor tasks, the simple reaction time (SRT) task and the one-increment task, to investigate the distinct contributions of beta (20 Hz) and gamma (70 Hz) oscillations to motor functions.ResultsBiochemical and neuropsychological tests revealed no significant differences between the groups. Additionally, no epileptic activities were detected in the EEG recordings. In the one-increment task, 20 Hz stimulation delayed participants’ reaction time compared to the 70 Hz and sham groups. Conversely, in the SRT task, 70 Hz stimulation exhibited a tendency to enhance participants’ performance relative to the sham group.ConclusionThe proposed high-current TI electrical stimulation is both safe and effective for stimulating the human brain. Moreover, the distinct effects observed in motor tasks underscore the dissociative roles of beta and gamma oscillations in motor functions, offering valuable insights into the potential applications of high-current TI electrical stimulation in brain stimulation research.

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Efficacy of transcranial alternating current stimulation in treating chronic insomnia and the impact of age on its effectiveness: A multisite randomized, double-blind, parallel-group, placebo-controlled study

Cited by 4 publications

References 38 publications

The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study

The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study

Transcranial direct current stimulation improves seizures frequency in drug-resistant epilepsy: A systematic-review and meta-analysis of randomized controlled trials

The safety and efficacy of applying a high-current temporal interference electrical stimulation in humans

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