Efficacy of transcranial direct current stimulation and cognitive training for the neurocognitive symptoms of long covid-19

Brunoni, André R.; Cavendish, Beatriz; Pinto, Bianca Silva; Pelosof, Rebeca; Pereira, Juliana; Neto, Adriano; Vidal, Kallene

doi:10.1016/j.brs.2023.01.232

Cited by 1 publication

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“…PASC treatment typically involves a multidisciplinary approach, including intervention from different medical disciplines, with treatment plans for NP-PASC often focusing on psychopharmacological treatment of symptoms, such as antidepressants or physical or cognitive rehabilitation tailored to the individual patient's needs. In our case, tDCS was not used to augment an established rehabilitation procedure as another NP-PASC tDCS study did 25,28 . TDCS was applied during patient activities (reading, housework, etc.)…”

Section: Tdcs As An Augmentation Of Rehabilitationmentioning

confidence: 97%

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Transcranial direct current stimulation (tDCS) in the treatment of neuropsychiatric symptoms of long COVID

Klírová,

Adamová,

Biačková

et al. 2024

Sci Rep

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The study aimed to assess the efficacy of transcranial direct current stimulation (tDCS) in the treatment of neuropsychiatric (NP) symptoms of the post-acute sequelae of SARS-CoV-2 infection (PASC), known as the long COVID. A double-blind, randomized, sham-controlled study compared the efficacy and safety of prefrontal cortex active tDCS to sham-tDCS in treating NP-PASC. Patients diagnosed with NP-PASC, with a Fatigue Impact Scale (FIS) score ≥ 40, were eligible for the study. Twenty tDCS sessions were administered within four weeks, with continuous, end-of-treatment, and follow-up measurements. The primary outcome was a change in the FIS at the end-of-treatment, analyzed in the intention-to-treat population. Data from 33 patients assigned to active (n = 16) or sham-tDCS (n = 17) were analyzed. After the treatment, a decrease in the FIS score was more pronounced in the sham than in the active group, yet the intergroup difference was insignificant (11.7 [95% CI −11.1 to 34.5], p = 0.6). Furthermore, no significant intergroup differences were observed regarding anxiety, depression, quality of life, and cognitive performance. The small cohort sample, differences in baseline FIS scores between groups (non-stratified randomization), or chosen stimulation parameters may have influenced our findings. However, it might also be possible that the expected mechanism of action of tDCS is insufficient to treat these conditions.

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Section: Tdcs As An Augmentation Of Rehabilitationmentioning

confidence: 97%

“…that were individually difficultno specific rehabilitation program was performed during tDCS. However, the choice of tDCS as an adjunct to targeted rehabilitation, as shown in some other studies 25,28,54 , may have led to different outcomes. Table 2.…”

Section: Tdcs As An Augmentation Of Rehabilitationmentioning

confidence: 99%