Efficacy of transnasal nebulized surfactant on experimental otitis media with effusion in guinea pig

Jang, Chul Ho; Park, Haekyun; Choi, Choong Hyeok; Cho, Yong Bum; Park, Il Yong

doi:10.1016/j.ijporl.2009.10.020

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…Goblet cells associated in normal numbers with the mucociliary epithelia of the middle ear mucosa are involved in the production of mucosal secretions and contribute to a normal immune response [38], [46], [47]. Our findings reveal morphological abnormalities of cilia in the mucociliary epithelia of middle ears that may cause an inability to clear secretions in Sh3pxd2b nee mutant mice.…”

Section: Discussionmentioning

confidence: 68%

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

et al. 2011

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Craniofacial defects that occur through gene mutation during development increase vulnerability to eustachian tube dysfunction. These defects can lead to an increased incidence of otitis media. We examined the effects of a mutation in the Sh3pxd2b gene (Sh3pxd2bnee) on the progression of otitis media and hearing impairment at various developmental stages. We found that all mice that had the Sh3pxd2bnee mutation went on to develop craniofacial dysmorphologies and subsequently otitis media, by as early as 11 days of age. We found noteworthy changes in cilia and goblet cells of the middle ear mucosa in Sh3pxd2bnee mutant mice using scanning electronic microscopy. By measuring craniofacial dimensions, we determined for the first time in an animal model that this mouse has altered eustachian tube morphology consistent with a more horizontal position of the eustachian tube. All mutants were found to have hearing impairment. Expression of TNF-α and TLR2, which correlates with inflammation in otitis media, was up-regulated in the ears of mutant mice when examined by immunohistochemistry and semi-quantitative RT-PCR. The mouse model with a mutation in the Sh3pxd2b gene (Sh3pxd2bnee) mirrors craniofacial dysmorphology and otitis media in humans.

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Section: Discussionmentioning

confidence: 68%

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

et al. 2011

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“…On the other hand, more animals might be needed for statistical significance of goblet cell count in the cartilaginous ET. Some recent studies using light microscopy or scanning electron microscopy found that transnasal PS reduced the thickness of the subepithelial layer, edematous mucosa, and glandular hyperplasia in the middle ear epithelium …”

Section: Discussionmentioning

confidence: 99%

Pathological study of otitis media with effusion after treatment with intranasal pulmonary surfactant

et al. 2013

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“…Based on this background, the intranasal instillation or local nebulization of surfactants has been tested in a number of animal models of experimental otitis media. The data consistently showed that local surfactant therapy has several benefits as it may (1) protect mucosa and reduce secretions, (2) favor tubes’ opening and secretions sliding, and (3) improve local histology and clinical course 66‐76 . These studies used animal surfactant preparations commonly used for respiratory indications 18 and have also been studied in combination with other treatments, such as local steroids, without significant differences 71,72 .…”

Section: Possible Extrapulmonary Surfactant Indicationsmentioning

confidence: 93%

“…The data consistently showed that local surfactant therapy has several benefits as it may (1) protect mucosa and reduce secretions, (2) favor tubes' opening and secretions sliding, and (3) improve local histology and clinical course. [66][67][68][69][70][71][72][73][74][75][76] These studies used animal surfactant preparations commonly used for respiratory indications 18 and have also been studied in combination with other treatments, such as local steroids, without significant differences. 71,72 Conversely, the addition of phenylephrine had a negative effect and was also able to abolish the effect of surfactant.…”

Section: Otitis Mediamentioning

confidence: 99%

Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues

Foligno

Loi

Pezza

et al. 2020

The Journal of Clinical Pharma

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Since the discovery of surfactant, a large amount of knowledge has been accumulated about its biology and pharmacology. Surfactant is the cornerstone of neonatal respiratory critical care, but its proteins and phospholipids are produced in various tissues and organs, with possible roles only partially similar to that played in the alveoli. As surfactant research is focused mainly on its respiratory applications, knowledge about the possible role of surfactant in extrapulmonary disorders has never been summarized. Here we aim to comprehensively review the data about surfactant biology and pharmacology in organs other than the lung, especially focusing in the more promising surfactant extrapulmonary roles. We also review any preclinical or clinical data available about the therapeutic use of surfactant in these contexts. We offer a summary of knowledge and research/development milestones, as possible useful guidance for researchers of multidisciplinary background.

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Efficacy of transnasal nebulized surfactant on experimental otitis media with effusion in guinea pig

Cited by 5 publications

References 21 publications

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

Sh3pxd2b Mice Are a Model for Craniofacial Dysmorphology and Otitis Media

Pathological study of otitis media with effusion after treatment with intranasal pulmonary surfactant

Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues

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