Efficacy of two calcium phosphate pastes on the remineralization of artificial caries: a randomized controlled double-blind in situ study

Abstract

To test the efficacy of two calcium phosphate pastes compared to that of fluoride toothpaste on remineralizing artificial caries in situ, this study had a double-blind crossover in situ design, involving three experimental phases of 14 days each, with an 8-day washout period between phases. Nine healthy subjects participated in the study. The subjects wore removable palatal appliances mounted with six human enamel slabs with artificial caries lesions, and in each of the experimental phases, used one of the following methods two times/day: group A, brushing with 1.0 g of Colgate Regular Flavor, followed by applying 0.25 g of Tooth Mousse Plus; group B, brushing with 0.25 g of Clinpro Tooth Crème; and group C, brushing with 1.0 g of Colgate Regular Flavor. After 14 days, the enamel slabs (54 slabs/group) were embedded in resin, sectioned and examined with a polarized-light microscope, and the lesion areas were quantified using Image-Pro Plus. All experimental groups showed a significant reduction in lesion area compared to the initial lesion area (paired t-test, P<0.001). The mean reduction in lesion area of Groups A, B and C were (0.029±0.010), (0.030±0.009) and (0.027±0.009) mm2, respectively. There were no statistical differences between groups (Kruskal–Wallis test, P>0.05). All three groups remineralized the enamel slab lesions, indicating model sensitivity to fluoride. Given the differences in usage amounts and treated regimens, Clinpro Tooth Crème provided similar benefits to the fluoride toothpaste; however, no additional benefit of Tooth Mousse Plus was observed when used in conjunction with the fluoride toothpaste.

Comparison of two kinds of skin imaging analysis software: VISIA® from Canfield and IPP® from Media Cybernetics

“…By integrating the RBX technology, cross‐polarized‐mode processing of subsurface red and brown features enables visualization of conditions such as rosacea, spider veins, melasma, and acne. Image‐Pro Plus (IPP ® ) is an image analysis software that has been widely used in many fields such as oral science, ophthalmology, pathology, and dermatology . Recently, IPP ® has been introduced into the field of beauty and cosmetics.…”

Effect of an Experimental Paste with Hydroxyapatite Nanoparticles and Fluoride on Dental Demineralisation and Remineralisation in situ

“…In respect of CPP-ACP, Vanichvatana and Auychai [2013] in their in situ study demonstrated that CPP-ACP with F has a remineralising effect on the enamel lesions as well as F, but no additional benefit of CPP-ACP with F associated with fluoride dentifrice was seen compared to fluoride dentifrice only. Another in situ study using CPP-ACP without fluoride showed that this product was less effective than fluoride dentifrice (long-term use) in remineralising caries lesions [Meyer-Lueckel et al, 2015].…”

Development and status of resin composite as dental restorative materials

“…To overcome demineralization leading to secondary caries, NACP and nanoparticles of dicalcium phosphate anhydrous (DCPA) have been added into composites. The addition and release of calcium phosphate ions may help remineralize the surrounding dentin to help inhibit secondary caries . These therapeutic composites with calcium and phosphate ions have been shown to effectively remineralize enamel and dentin lesions in vitro .…”