Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis

Razzi, S.; Luisi, Stefano; Calonaci, Francesco; Altomare, Aldo; Bocchi, Caterina; Petraglia, Felice

doi:10.1016/j.fertnstert.2006.12.077

Cited by 85 publications

(46 citation statements)

References 25 publications

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“…The safety and high compliance of vaginaladministered danazol agree with previous reports of vaginal administration in perimenopausal women (10,12) and in endometriotic women (11). A danazol-loaded IUD has been shown to be an effective and conservative treatment for dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis (14).…”

Section: Discussionsupporting

confidence: 86%

“…The use of danazol by vaginal route reduces the adverse side effects. Indeed, vaginal danazol proved to be effective in premenopausal women with AUB related to endometrial hyperplasia or endometrial polyps (12). The same treatment has been tested in a group of postmenopausal women gived vaginal danazol for 10 days every month for 6 months along with continuous transdermal E 2 counteracting the mitogenic effect of estrogen on the endometrium (10), as well as in women with deep infiltrating endometriosis for treating pelvic pain (11).…”

mentioning

confidence: 99%

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Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age

Luisi

Razzi

Lazzeri

et al. 2009

Fertility and Sterility

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Section: Discussionsupporting

confidence: 86%

mentioning

confidence: 99%

Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age

Luisi

Razzi

Lazzeri

et al. 2009

Fertility and Sterility

Self Cite

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“…Fedele et al [43] showed that, in women who had previously undergone conservative surgery for endometriosis without excision of deep lesions further treated with levonorgestrel intrauterine device (LNG-IUD), dysmenorrhoea, which had been moderate or severe in all cases, during treatment were absent. Other medical options, such as vaginal danazol (200 mg/day) were also tested on dysmenorrhoea and dyspareunia after surgery for DIE, showing a consistent and significant improvement in painful symptoms [44]. In a recent study of estroprogestin therapy, Mabrouk et al [45] reported that combined oral contraceptive therapy may have a role to play in restraining the progression of dysmenorrhoea and dyspareunia, and the growth of deep endometriotic nodules.…”

Section: Deep Infiltrating Endometriosis Diagnostic Imaging and Implimentioning

confidence: 99%

Imaging for the evaluation of endometriosis and adenomyosis

Exacoustòs

Manganaro

Zupi

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

211

143

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Endometriosis affects between 5 and 45% of women in reproductive age, is associated with significant morbidity, and constitutes a major public health concern. The correct diagnosis is fundamental in defining the best treatment strategy for endometriosis. Therefore, non-invasive methods are required to obtain accurate diagnoses of the location and extent of endometriotic lesions. Transvaginal sonography and magnetic resonance imaging are used most frequently to identify and characterise lesions in endometriosis. Subjective impression by an experienced sonologist for identifying endometriomas by ultrasound showed a high accuracy. Adhesions can be evaluated by real-time dynamic transvaginal sonography, using the sliding sign technique, to determine whether the uterus and ovaries glide freely over the posterior and anterior organs and tissues. Diagnosis is difficult when ovarian endometriomas are absent and endometriosis causes adhesions and deep infiltrating nodules in the pelvic organs. Magnetic resonance imaging seems to be useful in diagnosing all locations of endometriosis, and its diagnostic accuracy is similar to those obtained using ultrasound. Transvaginal ultrasound has been proposed as first line-line imaging technique because it is well accepted and widely available. The main limitation of ultrasound concerns lesions located above the rectosigmoid junction owing to the limited field-of-view of the transvaginal approach and low accuracy in detecting upper bowel lesions by transabdominal ultrasound. A detailed non-invasive diagnosis of the extension in the pelvis of endometriosis can facilitate the choice of a safe and adequate surgical or medical treatment

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“…In contrast, vaginally administered danazol improves pain symptoms caused by endometriosis with minimal adverse effects [12,13]. The daily administration of vaginal danazol does not affect the pituitary-ovarian axis [14] and does not inhibit ovulation [15].…”

Section: Introductionmentioning

confidence: 98%

Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel‐releasing intrauterine device

Ferrero

Tramalloni

Venturini

et al. 2011

Intl J Gynecology & Obste

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Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis

Cited by 85 publications

References 25 publications

Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age

Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age

Imaging for the evaluation of endometriosis and adenomyosis

Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel‐releasing intrauterine device

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