Efficacy of virtual reality-based interventions for patients with breast cancer symptom and rehabilitation management: a systematic review and meta-analysis

Abstract

ObjectivesTo determine the effectiveness of virtual reality (VR)-based intervention on the symptoms and rehabilitation management in patients with breast cancer.DesignSystematic review and meta-analysis.Study selectionWe included all eligible randomised controlled trials and quasi-experimental studies (published in English and Chinese).ParticipantsPatients with breast cancer (≥18 years) undergoing cancer treatment.InterventionsAny intervention administered to improve the symptoms and rehabilitation of patients with breast cancer. The control group was given conventional care.OutcomesAll outcomes were as follows: pain, fatigue, anxiety, depressive symptoms, cognitive function, and range of motion of upper limb in patients with breast cancer.Data sourcesWe searched PubMed, Embase, CENTRAL and SinoMed, four electronic databases, covering the database establishment period to January 2022.Review methodsTwo reviewers independently extracted content and data consistent with the prespecified framework and assessed risk bias. Random-effects meta-analysis was used to pool data across trials. Meta-analysis was performed using Review Manager V.5.4.ResultsA total of eight studies met the eligibility criteria and were included in this study. The combined effect size showed that VR was positive for improving patients’ anxiety(standard mean differenc (SMD)=−2.07, 95% CI= (−3.81 to −0.34), I2=95%) and abduction of upper limbs (MD=15.54, 95% CI= (12.79 to 18.29), I2=0%), but fatigue (SMD=−0.92, 95% CI= (−4.47 to 2.62), I2=99%) was not. Qualitative analysis showed VR improved patients' depressive symptoms, pain and cognitive function.ConclusionsVR technology has a good effect on symptoms and rehabilitation management of patients with breast cancer, but the quality of evidence is low, and the sample size is small. To date, there are few intervention studies, therefore, giving precise recommendation or conclusion is difficult. We have a favourable view of this, and more clinical studies are needed in the future to improve the credibility of the results.

Digital and Interactive Health Interventions Minimize the Physical and Psychological Impact of Breast Cancer, Increasing Women’s Quality of Life: A Systematic Review and Meta-Analysis

“…In comparison with previous reviews, VRBT and SABT were both effective, although the reduction in anxiety was greater when VRBT was employed. Our findings were in agreement with previous reviews of virtual reality and smartphone devices [ 32 , 35 ]. With respect to depression, DIHIs produced a large reduction, which was greater without the risk of publication bias, as demonstrated by trim-and-fill estimation.…”

“…Our findings suggest that DIHIs, especially non-immersive VRBT, are effective at increasing flexion, abduction, and external rotation shoulder range of motion. These results are in concordance with previous reviews, although Zhang H et al only assessed abduction shoulder ROM [ 35 ], and the work of Bu X et al, which included four studies, included one study that only examined one group of patients [ 36 ]. In comparison, we included more studies that considered this outcome.…”

“…Anxiety and depression are two psychological symptoms that can disable women with BC. Along with pain, anxiety is suffered by approximately 50% of patients [ 22 ], and depression appears in 97% [ 35 ], so it is important to find therapies that reduce their impact. Our findings revealed that DIHIs were effective at reducing anxiety.…”

“…To date, previous reviews have assessed the effect of DIHIs (VRBT [ 34 , 35 , 36 ] and SABT [ 32 , 37 ]) with promising results. However, the large heterogeneity in the design of the studies included and the fact that studies with only one group were combined with those with two or more groups may have minimized the impact of the results.…”

Digital health and telehealth in cancer care: a scoping review of reviews

“…The remaining 134 reviews met eligibility criteria and were included in the synthesis. 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 …”