Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies

Tangestani, Hadith; Djafarian, Kurosh; Emamat, Hadi; Arabzadegan, Niloufar; Shab‐Bidar, Sakineh

doi:10.1080/10408398.2018.1558172

Cited by 27 publications

(26 citation statements)

References 56 publications

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“…A recent meta-analysis of the impact of vitamin D-fortified foods on serum 25(OH)D levels, bone mineral density (BMD) and bone turnover markers (BTM) showed significant effects, with an increase in serum 25(OH)D and BMD and decrease in parathormone (PTH) levels. No significant beneficial effect on BTM was found [11].…”

Section: Calcium Vitamin D and Dairy Productsmentioning

confidence: 91%

Nutrients and Dietary Patterns Related to Osteoporosis

2020

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Osteoporosis is a common chronic disease characterized by a decrease in bone mineral density, impaired bone strength, and an increased risk of fragility fractures. Fragility fractures are associated with significant morbidity, mortality and disability and are a major public health problem worldwide. The influence of nutritional factors on the development and progression of this disease can be significant and is not yet well established. Calcium intake and vitamin D status are considered to be essential for bone metabolism homeostasis. However, some recent studies have questioned the usefulness of calcium and vitamin D supplements in decreasing the risk of fractures. The adequate intake of protein, vegetables and other nutrients is also of interest, and recommendations have been established by expert consensus and clinical practice guidelines. It is important to understand the influence of nutrients not only in isolation but also in the context of a dietary pattern, which is a complex mixture of nutrients. In this review, we evaluate the available scientific evidence for the effects of the main dietary patterns on bone health. Although some dietary patterns seem to have beneficial effects, more studies are needed to fully elucidate the true influence of diet on bone fragility.

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Section: Calcium Vitamin D and Dairy Productsmentioning

confidence: 91%

Nutrients and Dietary Patterns Related to Osteoporosis

2020

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“…The current review focuses on vitamin D fortified products and the subsequent health outcomes on the musculoskeletal system, using meta-analysis of randomized controlled studies. The most recent systematic review covering a similar topic was published by Tangestani et al ( 4 ). There are two main differences between their paper and the current review.…”

Section: Introductionmentioning

confidence: 99%

“…The main source of vitamin D synthesis in man is dermal synthesis following exposure to ultraviolet B waves of sunlight ( 4 ). Various environmental and cultural factors including season, latitude, use of sunscreens, aging, skin pigmentation and even job can affect the number of absorbed sunlight rays by the skin and cutaneous synthesis of this vitamin ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

“…Osteoporosis, characterized by loss of bone density and bone tissue degradation, is one of the main complications caused by vitamin D deficiency. Osteoporosis increases the risk of spontaneous fractures, especially in the elderly population ( 4 ). Two specific markers have been recommended as references by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and the International Osteoporosis Foundation (IOF).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Vitamin D Fortified Products on Bone Bi-omarkers: A Systematic Review and Meta-Analysis

Emadzadeh¹,

Mehdizadeh²,

Sharifan³

et al. 2022

ijph

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Background: Vitamin D plays an essential role in the regulation of bone metabolism. The current meta-analysis aimed to assess the effectiveness of vitamin D fortification on special bone biomarkers. Methods: Five main databases (PubMed/Medline, ISI Web of Knowledge, Science Direct, Scopus, Cochrane Library as well as Science Direct, and Scopus) were considered for this systematic review, until Jan 2020. All randomized controlled trials were included to evaluate the probable relationship between consumption of vitamin D fortification products and bone biomarkers profile in this review. Results: Among serum bone biomarkers (osteocalcin and telopeptides of type-1 collagen) investigated, only the level of telopeptides of type-1 collagen significantly decreased after fortification of vitamin D in the intervention group. A significant increase in vitamin D was seen in those older than 18 yr old, while the increase in younger children was not statistically significant between intervention and control groups. Conclusion: Vitamin D fortification was not associated with a significant improvement in bone mass density (BMD), while it resulted in decreased PTH levels. Vitamin D fortified foods have some benefits on bone health due to increase in the level of vitamin D and IGF-1; and decreasing PTH and CTx levels.

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“…Li et al reported that vitamin D played a role in promoting alkaline phosphatase (ALP) activity [ 16 ]. While a systematic review and meta-analysis of interventional studies showed association between serum 25(OH)D and bone density [ 17 ]. In addition, vitamin D supplementation might have contributed to liver and kidney fuction [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

Luo

Yun-ya

et al. 2022

BMC Pregnancy Childbirth

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Background The association between serum 25-hydroxy vitamin D (25(OH)D) status and gestational diabetes mellitus (GDM) gained attention in recent years, however the conclusion is still controversial due to many interfering factors, such as region of living, environment, lifestyle, and food supplements. Other metabolites (laboratory parameters) are also important in reflecting gestational states. This study aimed to investigate the association of serum 25(OH)D status in early pregnancy with GDM and other laboratory parameters in pregnant women. Methods A total of 1516 pregnant women whose blood glucose were normal before pregnancy in the city of Foshan in Guangdong, China were enrolled in this study. GDM was diagnosed between 24 to 28 weeks of pregnancy following the guidelines from the American Diabetes Association. Maternal serum 25(OH)D and other laboratory parameters—including hematology, coagulation, chemistry, and bone density—were measured utilizing various analytical methods in clinical laboratory at gestational weeks 11 to 14. Results The average 25(OH)D concentration was 59.1 ± 12.6 nmol/L. None of the study subjects had 25(OH)D < 25 nmol/L; 434 (28.6%) women had 25(OH)D deficiency (< 50 nmol/L), 882 women (58.2%) had 25(OH)D insufficiency (50–74 mmol/L) and 200 women (13.2%) had 25(OH)D sufficiency (≥ 75 nmol/L). There were 264 (17.4%) women diagnosed with GDM. There was not, however, an association between serum 25(OH)D in early pregnancy and GDM. Interestingly, women with more parity and high serum alkaline phosphatase levels had higher serum 25(OH)D levels. There was a possible positive association between serum 25(OH)D and pre-albumin, and a possible negative association between serum 25(OH)D, creatinine, and thrombin time. This study did not find an association between serum 25(OH)D and bone density. Conclusions There were no associations between maternal serum 25(OH)D concentration in early pregnancy and the risk of GDM or bone density. There were, however, correlations between serum 25(OH)D and parity, seasoning at sampling, serum alkaline phosphatase, creatinine, pre-albumin, and coagulation factor thrombin time, which need further study to explain their pathophysiology and clinical significance.

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Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies

Cited by 27 publications

References 56 publications

Nutrients and Dietary Patterns Related to Osteoporosis

Nutrients and Dietary Patterns Related to Osteoporosis

The Effects of Vitamin D Fortified Products on Bone Bi-omarkers: A Systematic Review and Meta-Analysis

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women

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