Efficacy of vitamin D loading doses on serum 25-hydroxy vitamin D levels in school going adolescents: an open label non-randomized prospective trial

Garg, Mahendra Kumar; Marwaha, Raman K.; Khadgawat, Rajesh; Ramot, Rekha; Obroi, Avneet Kaur; Mehan, Neena; Gupta, Nidhi; Madan, Renu

doi:10.1515/jpem-2012-0390

Cited by 31 publications

(40 citation statements)

References 12 publications

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“…4 Khadgawat et al, Garg et al and various other studies have also reported a high prevalence of vitamin D deficiency in Indian population. [6][7][8][9][10][11][12][13] In the present study, we found that after supplementation with vitamin D, the weight SD score of children increased significantly. This is due to direct influence of vitamin D levels on weight of the children.…”

Section: Discussionmentioning

confidence: 75%

Effect of vitamin D supplementation on growth parameters of children with vitamin D deficiency: a community based randomized controlled trial

Mugunthan

Rao

Midha

et al. 2017

Int J Contemp Pediatr

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Background: Vitamin D deficiency remains the most common cause of rickets globally and is highly prevalent in developing countries including India. This study aimed to compare the efficacy of vitamin D and calcium together with calcium alone on growth parameters of children with vitamin D deficiency in community based setting.Methods: A randomized controlled trial was conducted in community based setting in Kanpur district. Multistage random sampling technique was used to select a total of 395 children between 2 years to 5 years from 5 villages of block Vidhunu. Of these, 138 children were randomized into two groups using balanced block randomization technique. Group 1 received vitamin D with calcium together and group 2 received calcium alone for a period of 12 months. Anthropometry, serum vitamin D, calcium, alkaline phosphatase levels were estimated at baseline and after 12 months. Data was analyzed using SPSS 20. Student’s t test was used to analyze the differences in growth and laboratory parameters in the two groups. Multiple linear regression analysis was used to assess the effect of various factors on the growth parameters.Results: Prevalence of vitamin D deficiency was 78.7%. Baseline characteristics of both groups were similar. After 12 months, group 1 demonstrated significantly greater improvement in weight SD score (21.4%) and height SD score (10.3%) and growth velocity (9.1 cm/year) compared to group 2 (14.3%, 7.8% and 6.9 cm/ year respectively). Also subjects in group 1 showed significantly greater improvement in serum levels of vitamin D, calcium and alkaline phosphatase than group 2.Conclusions: Vitamin D supplementation along with calcium improves the growth of children. Regular supplementation of all children with vitamin D can be considered as a policy for prevention of malnutrition.

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Section: Discussionmentioning

confidence: 75%

Effect of vitamin D supplementation on growth parameters of children with vitamin D deficiency: a community based randomized controlled trial

Mugunthan

Rao

Midha

et al. 2017

Int J Contemp Pediatr

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“…In India, studies from different parts of the country have reported a high prevalence of VDD 96.9% (adolescents),[9] 90.8% (6–18 years),[10] 93.7% (school girls),[11] 92.3% (10–14 years)[12] and 87% (college students),[13] respectively. The cut-offs to define VDD, however, varied between the studies.…”

Section: Discussionmentioning

confidence: 99%

“…[8910111213] Majority of these studies have been conducted in plain regions of country. The common risk factors identified as associated with VDD are low exposure to sun,[14] atmospheric pollution,[15] darker skin pigmentation,[16] low physical activity,[17] indoor confinement of children during the day and high rise buildings.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Vitamin D deficiency and associated risk factors among children residing at high altitude in Shimla district, Himachal Pradesh, India

Kapil

Pandey

Goswami

et al. 2017

Indian J Endocr Metab

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Introduction:Vitamin D is important for bone development in children. A high prevalence of Vitamin D deficiency (VDD) has been documented from different parts of India. However, limited data are available on VDD among children residing at high altitude region of country.Objectives:To assess the prevalence of VDD and associated risk factors among children in the age group of 6–18 years in Shimla, Himachal Pradesh.Methods:A community-based cross-sectional study was conducted in the year 2014–2015. A total of 626 children in the age group of 6–18 years were enrolled from 30 clusters which were identified using population proportionate to size sampling method. A minimum of 20 children in the age group of 6–18 years per cluster were selected using random number tables. The data on socioeconomic status, physical activity, sunlight exposure, and biochemical parameters of bone and mineral metabolism were assessed.Results:Ninety-three percent of school-age children were found Vitamin D deficient as per serum 25(OH) D levels of <20 ng/ml. The prevalence was significantly higher among females.Conclusion:A high prevalence of VDD was found in children residing in high altitude region.

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“…Although we did not evaluate subjects for hypercalciuria using urinary calcium measurement, most recent studies from India and Turkey have failed to show any significant hypercalciuria in Vitamin D treated subjects. [3233]…”

Section: Discussionmentioning

confidence: 99%

Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency

Gupta

Farooqui

Batra

et al. 2017

Indian J Endocr Metab

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Context:A number of controversies exist regarding appropriate treatment strategy for Vitamin D deficiency.Aims:The aim of this study was to investigate the efficacy of equivalent doses of oral cholecalciferol (60,000 IU weekly for 5 weeks) versus intramuscular (IM) cholecalciferol (300,000 IU) in correcting Vitamin D deficiency in apparently healthy volunteers working in a hospital.Settings and Design:Prospective randomized open-label single institution study.Subjects and Methods:This study enrolled 40 apparently healthy adults with Vitamin D deficiency into 2 arms. The oral cholecalciferol group (n = 20) received oral cholecalciferol 60,000 IU weekly for 5 weeks while the IM cholecalciferol group (n = 20) received a single injection of cholecalciferol 300,000 IU. The main outcome measure was serum 25-hydroxyvitamin D (25OHD) levels at baseline, 6 and 12 weeks after the intervention.Statistical Analysis Used:Differences in serum 25OHD and other biochemical parameters at baseline and follow-up were analyzed using general linear model.Results:Mean 25OHD level at baseline was 5.99 ± 1.07 ng/mL and 7.40 ± 1.13 ng/mL (P = 0.332) in the oral cholecalciferol and IM cholecalciferol group, respectively. In the oral cholecalciferol group, serum 25OHD level was 20.20 ± 1.65 ng/mL at 6 weeks and 16.66 ± 1.36 ng/mL at 12 weeks. The corresponding serum 25OHD levels in the IM cholecalciferol group were 20.74 ± 1.81 ng/mL and 25.46 ± 1.37 ng/mL at 6 and 12 weeks, respectively. At 12 weeks, the mean 25OHD levels in IM cholecalciferol group was higher as compared to the oral cholecalciferol group (25.46 ± 1.37 vs. 16.66 ± 1.36 ng/mL; P < 0.001).Conclusions:Both oral and IM routes are effective for the treatment of Vitamin D deficiency. 25-hydroxyvitamin D levels in the IM cholecalciferol group showed a sustained increase from baseline.

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Efficacy of vitamin D loading doses on serum 25-hydroxy vitamin D levels in school going adolescents: an open label non-randomized prospective trial

Abstract: Supplementing 60,000 IU of vitamin D3 per week for 4-8 weeks, followed by 600 IU daily through fortified milk, is an effective strategy for achieving vitamin D sufficiency in Indian adolescents.

Cited by 31 publications

References 12 publications

Effect of vitamin D supplementation on growth parameters of children with vitamin D deficiency: a community based randomized controlled trial

Effect of vitamin D supplementation on growth parameters of children with vitamin D deficiency: a community based randomized controlled trial

Prevalence of Vitamin D deficiency and associated risk factors among children residing at high altitude in Shimla district, Himachal Pradesh, India

Effect of oral versus intramuscular Vitamin D replacement in apparently healthy adults with Vitamin D deficiency

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