Efficacy of vitamin D
            <sub>3</sub>
            supplementation in preventing fractures in elderly women: A meta-analysis

Bergman, Gert; Fan, Tao; McFetridge, Jeffrey T.; Sen, Shuvayu S.

doi:10.1185/03007991003659814

Cited by 57 publications

(42 citation statements)

References 44 publications

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“…However, despite the combination of vitamin D and calcium, other meta-analyses failed to show a consistent reduction in fracture risk. 36,38,40,41,43,[45][46][47][48][49] Factors that may explain these inconsistent results include an inadequate dose of vitamin D, different baseline values of vitamin D and therapeutic non-compliance with the supplements. 50 First, fracture prevention requires an adequate dose of vitamin D. This was shown in the meta-analyses of BischoffFerrari et al, 36,44,49 in which 700-800 IU or at least a dose in excess of 400 IU of vitamin D was required to reduce fracture risk.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D supplements with or without calcium to prevent fractures

2014

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Vitamin D deficiency is associated with fractures. This relationship is biologically plausible. The results of 19 randomized clinical trials with vitamin D with or without calcium show varying results: a decreased fracture incidence in 7, neutral in 10 trials, whereas 2 trials with a high dose of vitamin D once per year showed an increased fracture incidence. In three out of four well-powered trials that used recommended doses of vitamin D 700-1000 IU per day, vitamin D supplementation did not significantly influence fracture risk. In one of these trials, a statistically significant fracture reduction was observed in nursing home residents having severe vitamin D deficiency, low calcium intake and good compliance. Thirteen meta-analyses were done, and 11 of these showed a significantly decreased fracture incidence in the supplemented groups. Vitamin D alone was not effective, studies combining vitamin D and calcium showed inconsistent results. Analyses for vertebral fractures were negative in all cases. In conclusion, a vitamin D supplement of 800 IU per day in combination with calcium may decrease the incidence of non-vertebral fractures, especially in persons in the older age groups having low-baseline vitamin D status and low calcium intake and showing good compliance.

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Section: Discussionmentioning

confidence: 99%

“…[36][37][38][39][40][41][42][43][44][45][46][47][48][49] These meta-analyses are summarized in Table 2. The authors have subdivided the meta-analyses according to vitamin D dose, …”

Section: Meta-analysesmentioning

confidence: 99%

Vitamin D supplements with or without calcium to prevent fractures

2014

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“…Tras la primera criba se obtuvieron 22 artículos potencialmente de interés, de los cuales se excluyeron 20 (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), indicándose sus razones en la tabla III. En consecuencia, 2 artículos fueron incluidos para la elaboración de recomendaciones (17,38).…”

Section: Selección Y Síntesis De Evidenciasunclassified

Sumario de recomendaciones nutricionales basadas en la evidencia de la Guía de Prácti ca Clínica para el manejo de pacientes con enfermedad de Parkinson

2016

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Objetivos: dar a conocer las recomendaciones relacionadas con la Nutrición Humana y Dietética (NHyD) de la Guía de Práctica Clínica para elmanejo de la enfermedad de Parkinson del Sistema Nacional de Salud (GPC-EP/SNS) y favorecer su difusión e implementación en la práctica.El objetivo secundario es presentar la implicación de los profesionales de la NHyD en la elaboración de la guía.Material y métodos: siguiendo el Manual Metodológico de Elaboración de Guías de Práctica Clínica en el Sistema Nacional de Salud, se formularonlas preguntas clínicas, se realizó una búsqueda sistemática para cada pregunta en bases de datos (PubMed/Medline, Embase, CochraneLibrary, CRD, LILACS, IBECS y ClinicalTrials), se defi nieron los criterios de elegibilidad, al menos dos investigadores seleccionaron los estudios,se realizó lectura crítica de la literatura se resumió en tablas de síntesis de evidencia y se establecieron las recomendaciones.Resultados: se propusieron 14 preguntas relacionadas directamente con NHyD-Parkinson, de las cuales solamente 3 pudieron incluirse. Seformuló una pregunta relacionada con la terapia de logopedia aplicada en personas con EP que presentan problemas de deglución, tratamientodonde se imbrican los profesionales de la NHyD. De 642 artículos localizados, únicamente 2 pudieron ser incluidos para contestar las correspondientespreguntas. De las evidencias halladas, se derivaron 11 recomendaciones directa o indirectamente relacionados con la NHyD.Conclusiones: la implicación de profesionales sanitarios en equipos multidisciplinares mejora el resultado fi nal de las guías y la atención sanitariade los pacientes. Es necesario que los profesionales sanitarios de la NHyD (los/las dietistas-nutricionistas) se impliquen en iniciativas basadasen la mejor evidencia científi ca disponible y que formen parte de los equipos de trabajo multidisciplinares.

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“…What was a pleasing finding was the number of medication to reduce the harms associated with falls, for example Cholecalciferol (Vitamin D3) which is associated with decreasing the risk of fractures in elderly patients [59] and calcium supplements, were given routinely. Although used primarily to treat cardiac co-morbidities a number of patients who fell received Atorvastatin, Irbesartan or Simvastatin (Table 5).…”

Section: Medicationmentioning

confidence: 99%

Preventing falls in In-Patient Older Adult Mental Health Services: Different Causative Factors in Mental and Neurocognitive Disorders

Heslop¹,

Wynaden²,

Tohotoa³

2014

J Gerontol Geriatr Res

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Aims: To compare falls sustained in two groups of patients (one with mental disorders and the other neurocognitive disorders), in two acute inpatient older adult mental health services in Western Australia (WA).Background: Falls are the most common adverse event experienced during inpatient care. Older people with mental disorders and neurocognitive disorders constitute a high-risk group for accidental falls in hospitals.

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Efficacy of vitamin D ₃ supplementation in preventing fractures in elderly women: A meta-analysis

Cited by 57 publications

References 44 publications

Vitamin D supplements with or without calcium to prevent fractures

Vitamin D supplements with or without calcium to prevent fractures

Sumario de recomendaciones nutricionales basadas en la evidencia de la Guía de Prácti ca Clínica para el manejo de pacientes con enfermedad de Parkinson

Preventing falls in In-Patient Older Adult Mental Health Services: Different Causative Factors in Mental and Neurocognitive Disorders

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Efficacy of vitamin D 3 supplementation in preventing fractures in elderly women: A meta-analysis

Cited by 57 publications

References 44 publications

Vitamin D supplements with or without calcium to prevent fractures

Vitamin D supplements with or without calcium to prevent fractures

Sumario de recomendaciones nutricionales basadas en la evidencia de la Guía de Prácti ca Clínica para el manejo de pacientes con enfermedad de Parkinson

Preventing falls in In-Patient Older Adult Mental Health Services: Different Causative Factors in Mental and Neurocognitive Disorders

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Efficacy of vitamin D ₃ supplementation in preventing fractures in elderly women: A meta-analysis