Efficacy of Vitamin D3 Supplementation on Osseointegration of Implants

Javed, Fawad; Malmström, Hans; Kellesarian, Sergio Varela; Al‐Kheraif, Abdulaziz A.; Vohra, Fahim; Romanos, Georgios E.

doi:10.1097/id.0000000000000390

Cited by 59 publications

(59 citation statements)

References 41 publications

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“…In dental implantology, vitamin D has been investigated almost exclusively as influencing factor of the bone to implant contact and implant stability [17]. Vitamin D demonstrates several effects on bone metabolism: it upregulates the gene expression of osteocalcin, osteopontin, calbindin, and 24-hydroxylase, increases extracellular matrix protein formation by osteoblasts, and stimulates osteoclast activity [15, 43].…”

Section: Discussionmentioning

confidence: 99%

“…A relationship between bone metabolism, vitamin D, and early implant failure in human has not been proven to date. Vitamin D induces bone formation around implants in rodents [13–17]. Besides the classical function, findings of the last decades indicate vitamin D as an important immune regulator targeting both, the innate and adaptive immune response, since all cells of the immune system express vitamin d receptor (VDR) [18–20].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency in early implant failure: two case reports

et al. 2016

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An association between vitamin D deficiency and early dental implant failure is not properly verified, but its role in osteoimmunology is discussed. This article illustrates two case reports with vitamin D deficiency and early implant failure. Prior to implant placement, the first patient received crestal bone grafting with autologous material. Both patients received dental implants from different manufacturers in the molar region of the mandible. In the case of bone grafting in the first patient, all implants were placed in a two-stage procedure. All implants had to be removed within 15 days after implant placement. Vitamin D serum levels were measured: Both patients showed a vitamin D deficiency (serum vitamin D level <20 μg/l). After vitamin D supplementation, implant placement was successful in both patients. Prospective, randomized clinical trials must follow to affirm the relationship between vitamin D deficiency, osteoimmunology, and early implant failure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in early implant failure: two case reports

et al. 2016

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“…A total of 14 studies were considered for the literature review, 9 were animal studies and 5 studies used human subjects. The literature review in animals demonstrated that administration of vitamin D can induce bone formation as well as strengthen and support the interaction between bone and implants 29 31 . Locally applied vitamin D may escalate the bone-implant contact percentage by 10% 31 .…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, studies have found that vitamin D is markedly beneficial to the cardiovascular 16 , immune and respiratory systems 17,18 . Even though the significance of vitamin D and its involvement in bone metabolism have been well documented [19][20][21][22][23][24][25][26][27][28][29][30][31] , limited studies have been conducted on the effects of osseointegration of implants in dental patients. Specifically, the majority of them have been performed in animal experimental models [20][21][22][23][24][27][28][29]31 and only a small number in humans [15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

The role of vitamin D in dental implants osseointegration

Vesala¹,

Dontas²

2020

JRPMS

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Dental implants currently constitute a well-established solution for both functional and aesthetic restoration of complete and partial edentulism. Osseontegration, however, is a complex and multifactorial phenomenon bearing concerns as to its strong association to implant, prosthetics and surgical protocols, as well to patients themselves. This literature review aims to research into potential correlations linking the osseointegration process in dental implants to low levels of vitamin D in dental patients. A number of scientific articles were retrieved from PubMed and MEDLINE databases, using the following key words: "vitamin D deficiency"; "osseointegration"; and "vitamin D AND dental implants". Αll retrieved studies were limited to those involving human and animal experimental models, and only articles written in English. Nine animal studies investigated the osseointegration process in dental implants that may be attributed to the effects of vitamin D; and five studies used human subjects. However, none of the said studies demonstrated statistically significant differences. A number of patients, especially those with severe deficiency, reported beneficial outcomes following vitamin D systemic administration prior the surgery. In such patients, is important to maintain vitamin D levels, as it ensures bone reconstruction around the implant.

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“…. 64 D Vitamininin kemik metabolizmasındaki osteokalsin, osteopontin, calbindin ve 24 hidroksilaz seviyelerini yükselttiği, osteoblastlar tarafından yapılan ekstrasellüler matriks protein formasyonunu artırdığı ve osteoklast aktivitesini de sağladığı bilinmektedir. 65 Kemik formasyonunun arkasında D vitamini osteoimmunolojiyi desteklemekte bu da implantların erken iyileşmesine katkıda bulunmaktadır.…”

Section: Ağiz Sağliği Açisinda Yeni̇ Tedavi̇ Yaklaşimlariunclassified