Efficacy of vitamins B1 and B6 as an adjunctive therapy to lithium in bipolar-I disorder: A double-blind, randomized, placebo-controlled, clinical trial

Nutraceuticals in Psychiatric Disorders: A Systematic Review

“…No significant differences in mood were observed in patients compared to controls. On the contrary, in the RCT by Zandifar et al [131] 66 patients were randomized to take, in addition to standard lithium treatment, 100 mg/day of vitamin B1, 40 mg/day of vitamin B6, or placebo, and it was found that vitamin B6, but not vitamin B1, improved mood compared to placebo and that both improved quality of sleep compared to placebo [131].…”

“…Three studies on vitamin supplementation were conducted in the period examined [114,123,131]. As vitamin D supplementation seems to improve symptoms of unipolar depression, Marsh et al [114] administered 5000 IU/day of vitamin D for 12 weeks to patients suffering from BD and hypovitaminosis D, but did not find improvements in depressive, anxious, and manic symptoms measured with the Montgomery-Åsberg Depression Rating Scale (MADRS), the Hamilton Anxiety Rating Scale (HAM-A), and the Young Mania Rating Scale (YMRS).…”