Importance: The manuscript proposes the feasibility and potential of a remote Qigong intervention to reduce neuropathic pain in adults with spinal cord injury (SCI)-related neuropathic pain. Objective: We determined the feasibility and estimates of efficacy of a remotely delivered Qigong intervention in adults with SCI-related neuropathic pain. Design: This is a non-randomized controlled trial with outcomes assessed at baseline-, 6- and 12-weeks of Qigong practice, and at 6-weeks and 1-year follow-up. Setting: Completely remote clinical trial. Participants: Adults with SCI-related neuropathic pain, with SCI of at least 3 months, with complete or incomplete SCI, and highest neuropathic pain level of >3 on the Numeric Pain Rating Scale (NPRS). We used nationwide volunteer sampling. We recruited 23 adults with chronic SCI (7/2021-2/2022). Eighteen participants started the study and completed all study components, including the 6-week follow-up. Twelve participants completed the 1-year follow-up assessment. Intervention: Participants practiced the Spring Forest Qigong Five Element Healing Movements with an online video by combining movement with kinesthetic imagery, at least 3x/week for 12 weeks. Main Outcome(s) and Measure(s): To address the feasibility outcome and track adherence, the website automatically monitored the days and duration that the Qigong video was played. Self-report neuropathic pain intensity and SCI-related symptoms such as spasms, functional performance, mood, and body appreciation were also collected. Results: Eighteen participants, 60+/-12 years of age, 15+/-11 years post-SCI had a highest baseline neuropathic pain of 7.94+/-2.33 on the NPRS, which was reduced to 4.17+/-3.07 after 12 weeks of Qigong practice (Cohen d=1.75). This pain relief remained at 6-week and 1-year follow-ups. Participants reported reduced spasm frequency (change score 1.17+/-1.20, d=0.98) and severity (0.72+/-1.02, d=0.71), and reduced interference of neuropathic pain on mood (3.44+/-2.53, d=1.36), sleep (3.39+/-2.40, d=1.41), and daily activities (3.17+/-2.77, d=1.14). They had a greater ability to perform functional activities (Patient Specific Functional Scale, 6.68+/-3.07, d=2.18) and had improved mood (Patient Health Questionnaire-9, 2.33+/-3.31, d=0.70). Conclusions and Relevance: Our preliminary data demonstrate the feasibility of Qigong practice in adults with SCI-related neuropathic pain and promising results of neuropathic pain relief and improvement in SCI-related symptoms after Qigong practice.