Efficacy of Zotarolimus-Eluting Stents in Treating Diabetic Coronary Lesions: An Optical Coherence Tomography Study

Zhu, Zhaowei; Zhu, Jinzhou; Du, Rong; Zhang, Haotian; Ni, Jinwei; Quan, Weiwei; Hu, Jian; Ding, Fenghua; Yang, Zhenkun; Zhang, Ruiyan

doi:10.1007/s12325-020-01273-6

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…58 Subsequently, during a median duration of 4.8 years, 59 only 1 patient had gastrointestinal bleeding, 11 patients underwent target lesion revascularization, and all patients were free from hard end points (death, myocardial infarction, stroke, bypass surgery, or heart failure), reconfirmed the safety of an OCT-guided antithrombotic therapy without stenting for ACS caused by erosion. 59,60 In addition, OCT can also be used as an essential tool for evaluating intimal stent coverage 61 and adhesion 62 after PCI. A recently published case with poor stent expansion and probable severe calcification supported the effectiveness of excimer laser treatment under the guidance of OCT, 63 which may enlarge application scenarios for OCT-guided coronary intervention in the future.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

“…In addition, OCT can also be used as an essential tool for evaluating intimal stent coverage61 and adhesion62 after PCI. A recently published case with poor stent expansion and probable severe calcification supported the effectiveness of excimer laser treatment under the guidance of OCT,63 which may enlarge application scenarios for OCT-guided coronary intervention in the future.…”

Section: Imaging In Coronary Interventionmentioning

confidence: 99%

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The Chinese Experience of Imaging in Cardiac Intervention

Liu

Yang

Chen

2022

Journal of Thoracic Imaging

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Recent scientific and technological advances have greatly contributed to the development of medical imaging that could enable specific functions. It has become the primary focus of cardiac intervention in preoperative assessment, intraoperative guidance, and postoperative follow-up. This review provides a contemporary overview of the Chinese experience of imaging in cardiac intervention in recent years.

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Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

Section: Imaging In Coronary Interventionmentioning

confidence: 99%

The Chinese Experience of Imaging in Cardiac Intervention

Liu

Yang

Chen

2022

Journal of Thoracic Imaging

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Neovascularization restructuring patterns in diabetic patients with coronary in stent restenosis: an in-vivo optical coherence tomography study

Zhang,

Hui,

et al. 2024

Int J Cardiovasc Imaging

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Biosafety and efficacy evaluation of a biodegradable magnesium-based drug-eluting stent in porcine coronary artery

Zhu

Zhang

Niu

et al. 2021

Sci Rep

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Although the drug-eluting stent (DES) has become the standard for percutaneous coronary intervention (PCI)-based revascularization, concerns remain regarding the use of DES, mainly due to its permanent rigid constraint to vessels. A drug-eluting bioresorbable stent (BRS) was thus developed as an alternative to DES, which can be absorbed entirely after its therapeutic period. Magnesium (Mg)-based BRSs have attracted a great deal of attention due to their suitable mechanical properties, innovative chemical features, and well-proven biocompatibility. However, the primary disadvantage of Mg-based BRSs is the rapid degradation rate, resulting in the early loss of structural support long before the recovery of vascular function. Recently, a new type of patented Mg–Nd–Zn-Zr alloy (JDBM) was developed at Shanghai Jiao Tong University to reduce the degradation rate compared to commercial Mg alloys. In the present investigation, a poly(d,l-lactic acid)-coated and rapamycin eluting (PDLLA/RAPA) JDBM BRS was prepared, and its biosafety and efficacy for coronary artery stenosis were evaluated via in vitro and in vivo experiments. The degree of smooth muscle cell adhesion to the PDLLA/RAPA coated alloy and the rapamycin pharmacokinetics of JDBM BRS were first assessed in vitro. JDBM BRS and commercial DES FIREHAWK were then implanted in the coronary arteries of a porcine model. Neointimal hyperplasia was evaluated at 30, 90, and 180 days, and re-endothelialization was evaluated at 30 days. Furthermore, Micro-CT and optical coherence tomography (OCT) analyses were performed 180 days after stent implantation to evaluate the technical feasibility, biocompatibility, and degradation characteristics of JDBM BRS in vivo. The results show the ability of a PDLLA/RAPA coated JDBM to inhibit smooth muscle cell adhesion and moderate the drug release rate of JDBM BRS in vitro. In vivo, low local and systemic risks of JDBM BRS were demonstrated in the porcine model, with preserved mechanical integrity after 6 months of implantation. We also showed that this novel BRS was associated with a similar efficacy profile compared with standard DES and high anti-restenosis performance. These findings may confer long term advantages for using this BRS over a traditional DES.

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Efficacy of Zotarolimus-Eluting Stents in Treating Diabetic Coronary Lesions: An Optical Coherence Tomography Study

Cited by 3 publications

References 44 publications

The Chinese Experience of Imaging in Cardiac Intervention

The Chinese Experience of Imaging in Cardiac Intervention

Neovascularization restructuring patterns in diabetic patients with coronary in stent restenosis: an in-vivo optical coherence tomography study

Biosafety and efficacy evaluation of a biodegradable magnesium-based drug-eluting stent in porcine coronary artery

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