Efficacy, safety and economy of different doses of intravenous immunoglobulin in the treatment of idiopathic thrombocytopenic purpura in children: A systematic review and meta-analysis

Abstract

Review question / Objective: P: Patients d i a g n o s e d w i t h I d i o p a t h i c thrombocytopenic purpura (ITP), and under 18 years old. I: High dose regimen-standard dose of intravenous immunoglobulin (IVIG). C: Low dose regimen-lower dose than the standard dose of IVIG. O:Is there any difference between high dose and low dose regimen of IVIG in treatment for ITP children? Can low-dose regimen replace high-dose regimen ? S: Randomized Controlled Trial. Rationale: In 1981, Paul Imbach et al. applied IVIG to 7 children with chronic ITP INPLASY 1 International Platform of Registered Systematic Review and Meta-analysis Protocols INPLASY PROTOCOL Efficacy, safety and economy of different doses of intravenous immunoglobulin in the treatment of idiopathic thrombocytopenic purpura in children: A systematic review and meta-analysis Ren, XG 1 ; Zhang, MM 2 ; Ni, JY 3 ; Zhai, WS 4 . To cite: Ren et al. Efficacy, safety and economy of different doses of intravenous immunoglobulin in the treatment of idiopathic thrombocytopenic purpura in children: A systematic review and meta-analysis. Inplasy protocol 202270126.