Background: Photoaging is a complex biologic process that affects various layers of the skin. Amniotic membrane stem cell conditioned medium (AMSC-CM) that contain growth factors and have capability to improve clinical picture of photoaged skin. Microneedling and laser devices are transdermal drug delivery methods which shows promising results to improve photoaging .Objective: To investigate the efficacy of topical AMSC-CM after YAG erbium fractional laser compare to microneedling in photoaging.Method :A clinical study, 60 adult women with photoaging. Randomized into two groups A 30 women received AMSC-CM after fractional erbium:YAG laser (2940nm) and group B 30 woman received AMSC-CM after microneedling. Both groups received the treatment 3 times with 2 weeks interval. The improvement of pore, wrinkle, and UV spot as was evaluate before, after and post treatment using computer-stimulated photograph skin analyzer.
Result:The evaluation of pore and UV spot showed greater improvement in the group of AMSC-CM with fractional erbium:YAG laser compare to AMSC-CM with microneedling group (pore p:0,00 and UV spot p:0,00). There was no significant different (p 0.43) of wrinkle improvement between both groups.
Conclusion:The combination of AMSC-CM and fractional erbium:YAG laser have better efficacy in the improvement in photoaged skins.