Efficacy, Safety and Targets in Topical and Transdermal Active and Excipient Delivery

Mohammed, Yousuf; Moghimi, Hamid; Yousef, Shereen; Chandrasekaran, Navin Chandrakanth; Bibi, Césa R.; Sukumar, Sinduja; Grice, Jeffrey E.; Sakran, Wedad; Roberts, Michael S.

doi:10.1007/978-3-662-53270-6_23

Cited by 6 publications

(4 citation statements)

References 113 publications

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“…By leveraging these advancements, scientists and researchers can devise formulations that optimise active ingredientsʹ bioavailability, stability, and controlled release, thereby maximising their impact on skin health and rejuvenation [53][54][55]. Traditional topical skin care formulations may have limitations that affect their safety and efficacy [56]. Researchers have developed various nanomaterials to overcome these limitations to facilitate drug delivery [57].…”

Section: Combination Niacinamidementioning

confidence: 99%

Exploring the Potential of Nanotechnology in Cosmetics: Incorporating Natural Ingredients for Enhanced Skin Benefits

Tören,

Yalçınkaya,

Buzgo

2023

Preprint

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This article presents a comprehensive overview of the utilisation of nanotechnology in the cosmetics industry, with a specific focus on developing nanoparticles for the efficient delivery of active ingredients through skin penetration. The review delves into incorporating natural ingredients in cosmetics, exploring their therapeutic properties and the advantages and limitations associated with their use. Furthermore, the article examines the benefits of integrating natural ingredients into skincare products to enhance skin conditions, highlighting the application of nonfibrous technology in areas such as UV protection, anti-ageing effects, moisturisation improvement, and wound healing. Ultimately, the article emphasises the immense potential of nanotechnology to create innovative opportunities and positive societal impacts across various industries.

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Section: Combination Niacinamidementioning

confidence: 99%

Exploring the Potential of Nanotechnology in Cosmetics: Incorporating Natural Ingredients for Enhanced Skin Benefits

Tören,

Yalçınkaya,

Buzgo

2023

Preprint

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“…1,19,20 In combination with their flexibility and biocompatibility (depending on the composition), this can enhance the transport of various therapeutics into the viable epidermis, 11,21 the origin of inflammatory conditions such as dermatitis or eczema. 22,23 However, the NGs themselves are not able to pass the intact SC. 24,25 While a detailed understanding of the underlying mechanism remains elusive, it is assumed that two factors govern the topical delivery potential of NGs: First, the water-swollen NGs lead to hydration of the SC which is accompanied by a rearrangement of the lipid structure and reduction of the barrier function.…”

Section: ■ Introductionmentioning

confidence: 99%

“…To overcome this obstacle, a variety of different drug delivery systems have been investigated based on lipids, , polymeric micelles, − and (polymer) nanoparticles. , Within polymeric nanocarriers, nanogels (NGs) exhibit a number of advantages due to their unique combination of colloidal size, structural stability (no critical micelle concentration), colloidal stability (no surfactants needed), and (stimuli-responsive) internal network that defines mechanical and diffusion properties. ,, In combination with their flexibility and biocompatibility (depending on the composition), this can enhance the transport of various therapeutics into the viable epidermis, , the origin of inflammatory conditions such as dermatitis or eczema. , However, the NGs themselves are not able to pass the intact SC. , While a detailed understanding of the underlying mechanism remains elusive, it is assumed that two factors govern the topical delivery potential of NGs: First, the water-swollen NGs lead to hydration of the SC which is accompanied by a rearrangement of the lipid structure and reduction of the barrier function . Second, it is assumed that they interact with the amphiphilic SC and accumulate in its upper part, where they act as drug depots for sustained or stimuli-responsive release. ,, …”

Section: Introductionmentioning

confidence: 99%

Influence of Nanogel Amphiphilicity on Dermal Delivery: Balancing Surface Hydrophobicity and Network Rigidity

et al. 2021

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Polymeric nanogels are promising nonirritating nanocarriers for topical delivery applications. However, conventional hydrophilic networks limit encapsulation of hydrophobic therapeutics and hinder tailored interactions with the amphiphilic skin barrier. To address these limitations, we present amphiphilic nanogels containing hydrophilic networks with hydrophobic domains. Two competing factors determine favorable nanogel− skin interactions and need to be balanced through network composition: suitable surface hydrophobicity and low network rigidity (through physical hydrophobic cross-links). To ensure comparability in such investigations, we prepared a library of nanogels with increasing hydrophobic cholesteryl amounts but similar colloidal features. By combining mechanical and surface hydrophobicity tests (atomic force microscopy (AFM)) with dermal delivery experiments on excised human skin, we can correlate an increased delivery efficacy of Nile red to the viable epidermis with a specific network composition, i.e., 20−30 mol % cholesterol. Thus, our nanogel library identifies a specific balance between surface amphiphilicity and network rigidity to guide developments of advanced dermal delivery vehicles.

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“…They improve penetration through altering the skin's protective characteristics, raising the skin to vehicle partition coefficient and the thermodynamic activity of substances. [28][29][30][31][32] TDDS employees a variety of rate controlling mechanism including matrix diffusion, membrane diffusion, biodegradation and osmosis. There are two main objectives of this drug delivery system; (1) Drug Targeting: This means to deliver a drug to desired location in body and (2) Controlled Release: This state to deliver a drug at desired rate over a desired length of time.…”

mentioning

confidence: 99%

Devising of Lazūq (A Conventional Unani Dosage Form) with reference to Transdermal Patch; Then and Now: A Critical Review

Amreen,

Siddiqui,

Saleem

2024

J. Drug Delivery Ther.

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Objective: The endeavor is made to criticize the classical indications, preparations and application of Lazūq even after passing many centuries since its inception. Background: According to classical Unani literature, Lazūq is primarily formulated for headache, migraine, toothache, cervical pain, dropping of uvula and different types of pain like sciatica, backache, myalgia and some orthopedic conditions. Its approach is still conventional that encompasses thick sticky stuff of drug/s which is pasted over a cloth or thick paper, consequently, maximum ratio of medicinal properties remains insignificant owed to stratum corneum (layer of skin that functions as a barrier). Devising and method of drug delivery in classical form of Lazūq makes it inconvenient to the patient, thus, it drops patient’s compliance and anticipated efficacy. In this day and age, Unani practitioners do not prescribe it very often because of its devising and limited indications documented in classical literature. Hence, it’s now becoming out of practice. Whereas, modern medicine is practicing its novel approach epitomized as Transdermal patch for several bodily conditions like Acute post-operative pain, Alzheimer disease, Angina pectoris, Anti-emetic patch, Atrial fibrillation, Attention deficit hyperactivity disorder, Dementia, Depression, Dysmenorrhea, Hypertension, Local dermal analgesia, Menopausal symptoms, Motion sickness, Osteoporosis, Overactive bladder, Parkinson’s disease, Post herpetic neuralgia pain, Smoking cessation, Tic disorder, Tourette syndrome and to prevent pregnancy. In transdermal patch, drug is used in micro/nano form with chemically produced permeation enhancers (CPEs) and other smart physio-chemical techniques that makes it very easy to apply, imparts maximum active pharmaceutical ingredients with controlled release of drug. Methodology: Ancient classical Unani formulations of Lazūq was appraised and then its course with respect to today’s newer formulations as transdermal patch was reviewed to look for its progress and application in novel dosage form with the advantage of innovations in pharmaceutical and allied sciences. Conclusion: Classical Unani formulations of Lazūq must be reviewed, transformed, evaluated, coped and applied as per the standard operating procedures (SOPs) of transdermal drug delivery system. Future Prospects: New formulations of Lazūq should be designed and appraised from the medicinal treasure of Unani system of medicine for different therapeutic conditions.

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Efficacy, Safety and Targets in Topical and Transdermal Active and Excipient Delivery

Cited by 6 publications

References 113 publications

Exploring the Potential of Nanotechnology in Cosmetics: Incorporating Natural Ingredients for Enhanced Skin Benefits

Exploring the Potential of Nanotechnology in Cosmetics: Incorporating Natural Ingredients for Enhanced Skin Benefits

Influence of Nanogel Amphiphilicity on Dermal Delivery: Balancing Surface Hydrophobicity and Network Rigidity

Devising of Lazūq (A Conventional Unani Dosage Form) with reference to Transdermal Patch; Then and Now: A Critical Review

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