Efficacy studies on a canarypox-rabies recombinant virus

Taylor, Jill; Trimarchi, Charles V.; Weinberg, Randall; Languet, B.; Guillermin, Francois; Desmettre, P; Paoletti, Enzo

doi:10.1016/0264-410x(91)90152-v

Cited by 151 publications

(55 citation statements)

References 20 publications

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“…6320), and were not seen in any other group. In mammalian hosts and poultry, recombinant vaccines created from Avipox genera, such as fowlpox and canarypox, have been considered safe and immunogenic (Taylor et al 1988(Taylor et al , 1991, and the WNV canarypox vaccine has been shown to be safe and effective in horses, dogs, and cats (Minke et al 2004, Karaca et al 2005. The lesions noted at the vaccine inoculation sites in our study may have been due to replication of the recombinant canarypox virus, and we recommend that the Merial vaccine be assessed carefully before its use in other avian species, especially passerines.…”

Section: Efficacy Of Wnv Vaccines In Western Scrub-jaysmentioning

confidence: 99%

Efficacy of Three Vaccines in Protecting Western Scrub-Jays (Aphelocoma californica) from Experimental Infection with West Nile Virus: Implications for Vaccination of Island Scrub-Jays (Aphelocoma insularis)

Wheeler

Langevin

Woods

et al. 2011

Vector-Borne and Zoonotic Diseases

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The devastating effect of West Nile virus (WNV) on the avifauna of North America has led zoo managers and conservationists to attempt to protect vulnerable species through vaccination. The Island Scrub-Jay (Aphelocoma insularis) is one such species, being a corvid with a highly restricted insular range. Herein, we used congeneric Western Scrub-Jays (Aphelocoma californica) to test the efficacy of three WNV vaccines in protecting jays from an experimental challenge with WNV: (1) the Fort Dodge West Nile-Innovator Ò DNA equine vaccine, (2) an experimental DNA plasmid vaccine, pCBWN, and (3) the Merial Recombitek Ò equine vaccine. Vaccine efficacy after challenge was compared with naïve and nonvaccinated positive controls and a group of naturally immune jays. Overall, vaccination lowered peak viremia compared with nonvaccinated positive controls, but some WNV-related pathology persisted and the viremia was sufficient to possibly infect susceptible vector mosquitoes. The Fort Dodge West Nile-Innovator DNA equine vaccine and the pCBWN vaccine provided humoral immune priming and limited side effects. Five of the six birds vaccinated with the Merial Recombitek vaccine, including a vaccinated, non-WNV challenged control, developed extensive necrotic lesions in the pectoral muscle at the vaccine inoculation sites, which were attributed to the Merial vaccine. In light of the well-documented devastating effects of high morbidity and mortality associated with WNV infection in corvids, vaccination of Island Scrub-Jays with either the Fort Dodge West Nile-Innovator DNA vaccine or the pCBWN vaccine may increase the numbers of birds that would survive an epizootic should WNV become established on Santa Cruz Island.

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Section: Efficacy Of Wnv Vaccines In Western Scrub-jaysmentioning

confidence: 99%

Efficacy of Three Vaccines in Protecting Western Scrub-Jays (Aphelocoma californica) from Experimental Infection with West Nile Virus: Implications for Vaccination of Island Scrub-Jays (Aphelocoma insularis)

Wheeler

Langevin

Woods

et al. 2011

Vector-Borne and Zoonotic Diseases

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“…The viruses undergo abortive replication and fail to produce infectious progeny virus in mammalian cell lines and animals. But they can achieve expression of foreign gene products and function effectively as an immunization vector for both animals and humans [29,108,110,111,123]. For example, sufficient expression of the rabies virus glycoprotein was obtained with a recombinant FPV to protect in immunized mice, cats, and dogs [108] and the recombinant vaccine based on canarypox virus was shown to be more effective than that based on FPV [110].…”

Section: ) Avipox Virusesmentioning

confidence: 99%

“…Protective efficacy of chickens against avian influenza virus [6,107], NDV [9,84,109], infectious bursal disease virus [5,35], avian leukosis virus [82], avian reticuloendotheliosis virus [13], and Marek's disease virus [81] has recently been reported. Canarypox [110] and pigeonpox [58] vectors have also been described. Both vaccinia and avipoxvirus promoters were used for expression.…”

Section: ) Avipox Virusesmentioning

confidence: 99%

“…But they can achieve expression of foreign gene products and function effectively as an immunization vector for both animals and humans [29,108,110,111,123]. For example, sufficient expression of the rabies virus glycoprotein was obtained with a recombinant FPV to protect in immunized mice, cats, and dogs [108] and the recombinant vaccine based on canarypox virus was shown to be more effective than that based on FPV [110]. In other reports, both FPV [123] and canarypox virus [111] vectors expressing measles virus (MV) antigens induced a protective immunity in animals against MV or the related canine distemper virus challenge.…”

Section: ) Avipox Virusesmentioning

confidence: 99%

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Recombinant Viral Vector Vaccines for the Veterinary Use.

Yokoyama

Maeda

Mikami

1997

The Journal of Veterinary Medical Science

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ABSTRACT. Recently, genetically engineering using recombinant DNA techniques has been applied to design new viral vaccines in order to reduce some problems which present viral vaccines have. Up to now, many viruses have been investigated for development of recombinant attenuated vaccines or live viral vectors for delivery of foreign immunogenic antigens. In this review, we introduced three kind of viruses; herpesviruses, vaccinia viruses, and adenoviruses, which have best widely been studied as recombinant vaccines or delivery vaccines for the veterinary use. -KEY WORDS: recombinant polyvalent vaccine, recombinant vaccine, viral vector.

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“…For example, ALVAC-RG protected dogs and cats against rabies [27], an ALVAC recombinant expressing the EIV type Al and type A2 HA glycoproteins protected horses against EIV [28] and an ALVAC recombinant expressing the feline leukaemia virus (FeLV) gag and env proteins protected cats against FeLV [29].…”

Section: Poxvirusesmentioning

confidence: 99%